Resumo

BERNAL FORIGUA, Camila et al. Epigenetic Control of Epithelial-Mesenchymal Transition. Univ. Med. [online]. 2020, vol.61, n.1, pp.52-73. ISSN 0041-9095.  https://doi.org/10.11144/javeriana.umed61-1.epig.

The mesenchymal epithelial transition (MET) process allows a temporary epithelial cell to acquire a mesenchymal phenotype in response to an internal or external stimulus. This process is characterized by the activation and repression of genes involved in different signaling pathways associated with migration, invasion and apoptosis, among others. In this process epigenetics plays a fundamental role. Epigenetics comprises four mechanisms: DNA methylation, covalent modification of histones, non-coding RNAs (RNACs) and chromatin remodeling complexes, which regulate the expression of a gene without altering its sequence. In this topic review, the authors describe the main epigenetic mechanisms involved in the regulation of the expression of genes that are activated and repressed throughout the TEM process.

Palavras-chave : epigenetics repression; epithelial-mesenchymal transition; transcription genetic.

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