Abstract

TOVAR SANCHEZ, Catherin et al. What Recent Advances are there in the Understanding, Diagnosis and Treatment of von Willebrand Disease? A Literature Review. Univ. Med. [online]. 2020, vol.61, n.2, pp.34-48.  Epub Jan 30, 2020. ISSN 0041-9095.  https://doi.org/10.11144/javeriana.umed61-2.vonw.

Von Willebrand disease (vWD) is the most common hereditary bleeding disorder, affects up to 1% of the population and comprises a spectrum of heterogeneous subtypes. It is characterized by mutations that lead to a decrease in the level or deterioration in the action of von Willebrand factor (vWF). Most cases are transmitted as autosomal dominant. The diagnostic tests for this disorder are complex, and the proper interpretation requires a thorough understanding of the underlying pathophysiology by the health care group. The objective of this review is to discuss the epidemiology, pathophysiology, and the most recent advances in the diagnosis and treatment of vWD.

Keywords : von Willebrand disease; von Willebrand factor; hemorrhagic diathesis; deamino arginine vasopressin.

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