Introduction:

Coffee is a drink that is associated with metabolic changes, including changes in the lipid profile. On the other hand, lipid alterations, such as increased LDL cholesterol or decreased HDL cholesterol, are associated with adverse cardiovascular outcomes. Taking into account the frequency of consumption of this drink and the recent evidence regarding its impact on cardiovascular system and deaths, it is necessary to review the recent evidence to understand how coffee consumption modifies the lipid profile.

Methods and analysis:

We will search Embase, Pubmed, BVS and Cochrane from inception to March 2021 with language restriction to French, Spanish and English. We will include meta-analyses and systematic reviews that evaluate the impact of coffee consumption on the lipid profile in adults. Methodological quality of each study will be evaluated using the Assessment of Multiple Systematic Reviews 2 (Amstar2) tool. The heterogeneity of the results reported using the I2 estimator will be taken into account. A sensitivity analysis of the results will be carried out by subgroups according to the quality of the included studies.

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