Abstract

MOLINA-PIMIENTA, Luisana; RONDON-CARVAJAL, Julián  and  SALGADO-SANCHEZ, Juan Camilo. High Vitamin B12 Levels: How to Interpret Them?. Univ. Med. [online]. 2022, vol.63, n.1, pp.81-91.  Epub Dec 30, 2021. ISSN 0041-9095.  https://doi.org/10.11144/javeriana.umed63-1.vita.

High levels of cobalamin (Hypervitaminemia b12) are a frequent and underestimated finding in clinical practice, often incidental. A methodical approach is required, which allows not only to rule out a functional deficiency of the same according to the context, but also to guide its etiology, considering that it could be an early finding in the course of ominous prognostic entities, such as some solid tumors, liver diseases of acute or chronic course and myeloproliferative disorders, among which chronic myeloid leukemia stands out. Similarly, it allows differentiating primary causes of high cell counts from both erythroid lineage (polycythemia) and myeloid lineage (neutrophilia, eosinophilia). A diagnostic algorithm is proposed, based on the medical literature available to date on the subject.

Keywords : B12 vitamin; transcobalamins; hypervitaminemia b12; myeloproliferative disorders; cancer; neoplasm metastasis.

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