Resumo

AGUIRRE, Gustavo A.; FALLA, Andrés  e  SANCHEZ, William. Correlation of the inflammatory markers (C reactive protein, neutrophilia and leukocytosis) in the different phases of acute appendicites. rev. colomb. cir. [online]. 2014, vol.29, n.2, pp.110-115. ISSN 2011-7582.

Objective: To determine if there is a correlation between the elevation of inflammatory markers such as C reactive protein (PCR), leukocytosis and neutrophilia with the different stages of acute appendicitis. Materials and Methods: Prospective study carried out between January and May 2011 to evaluate 100 patients with a clinical diagnosis of acute appendicitis that were brought to surgery with clinical evolution of maximum 24 hours and that on admission hemogram and PCR measurement were done, in order to establish the diagnostic correlation between pro-inflammatory markers and the surgical and pathological findings. The statistical analysis was done with the program epi info and variables were analyzed using chi square test. Results: 100 patients were collected, 74 met inclusion criteria. We evaluated the relationship between the stage of the disease and the levels of CRP, leukocytosis and neutrophilia. There was a great increase in the levels of CRP in patients with complicated appendicitis (gangrenous and perforated) with an ROC value of 1.7 mg/dl (range 8.7 - 14.85 mg/dl). Global diagnostic sensitivity diagnose of this test was 75.6 %, with a lift to the 93.1 % in complicated phases (p = 0.01). Conclusions: PCR levels and the neutrophilia are inflammatory markers with high sensitivity in the diagnosis of acute appendicitis. There is a direct and proportional correlation with the levels of inflammatory markers in patients with a high clinical suspicion. Our results will help to define the therapeutic conduct, observing that PCR scoring values superior to 11.7 PCR mg/dl and neutrophils higher than 82 % correlate with advanced stages of acute appendicitis.

Palavras-chave : appendicitis; inflammation; biological markers; diagnosis; evaluation.

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