Abstract

BELTRAN, Marcelo A.. Zollinger-Ellison syndrome: review of current knowledge. rev. colomb. cir. [online]. 2016, vol.31, n.3, pp.197-211. ISSN 2011-7582.

Zollinger-Ellison syndrome is characterized by peptic ulcers refractory to treatment secondary to ectopic gastrin hypersecretion by a neuroendocrine tumor called gastrinoma resulting in gastric hydrochloride acid hypersecretion. This syndrome occurs sporadically and is also associated to Multiple Neuroendocrine Neoplasia type 1. The present article describes their clinical presentations, as well as their pathophysiology, diagnosis, study, treatment and prognosis, emphasizing the surgical technical details. Early diagnosis of gastrinoma carries a good prognosis, even in those malignant cases. Consequently, clinical suspicion associated to specific study leading to diagnosis and treatment is fundamental for these patients. Due to the available current technology, the diagnosis of these tumors should be more common, as a consequence the knowledge of important details within their management is important for the surgeon.

Keywords : Zollinger-Ellison syndrome; gastrinoma; gastrins; multiple endocrine neoplasia; peptic ulcer.

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