Abstract

JIMENEZ, César Eduardo; RANDIAL, Leonardo  and  SILVA, Iván. Use of stem cells in the treatment of critical ischemia. rev. colomb. cir. [online]. 2017, vol.32, n.2, pp.146-151. ISSN 2011-7582.  https://doi.org/10.30944/20117582.18.

Critical ischemia of the lower limbs is defined as insufficiency of arterial flow to the lower limbs to maintain tissue viability, usually caused by obstructive peripheral arterial disease. The clinical manifestations are pain at rest and presence of ulcers or spontaneous tissue loss. Management with surgical revascularization and endovascular therapy has shown high limb salvage, but in spite of these advances approximately 20% to 40% of patients with critical limb ischemia are not candidates for any of these therapies. It is estimated that between 120 and 500 amputations are doing per year per million inhabitants per arterial disease; 25% of patients with major amputations do not receive rehabilitation. Therefore, we need new strategies to promote limb salvage and reduce such high amputation rates. The use of stem cells over the last 20 years has proven to be an effective and safe treatment for patients with critical ischemia with a high risk of limb loss.

Keywords : Pluripotent stem cells; stem cell transplantation; ischemia; lower extremity; peripheral arterial disease.

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