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Revista Colombiana de Cirugía
versión impresa ISSN 2011-7582versión On-line ISSN 2619-6107
Resumen
HERRERA-TORO, Natalia; PENA-AGUIRRE, Laura y MOLINA, Federico. Factors associated with survival in patient with Wilms tumor. rev. colomb. cir. [online]. 2020, vol.35, n.4, pp.621-629. Epub 15-Feb-2021. ISSN 2011-7582. https://doi.org/10.30944/20117582.556.
Introduction.
Wilms tumor is the second most frequent abdominal tumor in pediatric age, and it accounts for more than 90% of kidney tumors in pediatrics. Although the described survival is greater than 90%, in our setting we find that it only reaches 70%. Our objective was to evaluate the factors associated with these unfavorable results, in order to implement measures to improve the survival of our patients.
Methods.
An observational, cross-sectional study was conducted in two tertiary medical centers, which included a sample of 84 patients under 15 years of age with a diagnosis of Wilms tumor.
Results.
The factors that were significantly associated with an increase in the probability of dying were not completing the chemotherapy protocol (OR 34; 95%CI 3.7-312; p 0.000) and presenting tumor recurrence (OR 35.7; 95%CI 6.9-184; p 0.000). Other factors that increased this probability without being significant, but showing an evident trend were: bilateral presentation (OR 4.1; 95%CI 0.6-5.5; p 0.147), surgical complications (OR 3.2; 95%CI 0.7-14.6; p 0.136), lymph node involvement in tomography (OR 2.4; 95%CI 0.7-8.4; p 0.139) and distant metastases (OR 2.5; 95%CI 0.7-9; p 0.143).
Discussion.
The survival of the children with Wilms tumor in our study was lower than that reported in the world literature, with failure to complete chemotherapy, recurrence and the need for bilateral surgery being the factors associated with this outcome.
Palabras clave : Wilms tumor; nephroblastoma; surgery; urology; surgical oncology; cancer survivors.