Resumo

RIDHO, Fiki M. et al. Periodontal disease and prostate cancer: a systematic review and meta-analysis. Urol. Colomb. [online]. 2025, vol.34, n.3, pp.173-181.  Epub 02-Set-2025. ISSN 2027-0119.  https://doi.org/10.24875/ruc.25000018.

This study aims to determine the association between periodontal disease (PD) and prostate cancer (PC) using systematic review and meta-analysis. Any observational studies investigating the association between PD and PC published in PubMed, Scopus, ScienceDirect, and Google Scholar from inception to 2024 were reviewed. The Newcastle-Ottawa Scale was used to assess study quality. Stata version 17.0 software was used for all statistical analyses. The study's findings were reported as odds ratios (ORs) with 95% confidence intervals (CIs) through fixed- or random-effects model meta-analysis. Nine studies involving 621,982 male participants aged > 20 years were finally included in this meta-analysis. The fixed-effects model meta-analysis revealed a significant association between PD and PC (OR = 1.19; 95% CI = 1.12-1.28; p = 0.0000). The present meta-analysis was robust based on the results of sensitivity analysis. This meta-analysis demonstrates a significant association between PD and PC, potentially driven by chronic inflammation and migration of periodontal pathogenic bacterial.

Palavras-chave : Oral health; Periodontal disease; Periodontitis; Prostate cancer.

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