Abstract

GONZALEZ-CORRALES, Daniela; MONGE-QUIROS., Tatiana  and  ALFARO-MORA, Ramsés. Adverse effects related to the use of NSAIDs in the selection and management of feline and canine osteoarthritis. rev. colombiana cienc. anim. Recia [online]. 2021, vol.13, n.1, pp.77-88.  Epub Jan 24, 2023. ISSN 2027-4297.  https://doi.org/10.24188/recia.v13.n1.2021.781.

The mechanism of action of nonsteroidal anti-inflammatory drugs (NSAIDs) consists of reducing the production of prostaglandins (PG) by the inhibition of cyclooxygenase enzymes (COX). Older patients are more susceptible to experience side effects, due to a reduction of metabolism and drug excretion rate. It is recommended not to administer NSAIDs to hypovolemic, dehydrated or hypotensive patients and special care should be taken in patients with cardiac, renal, hepatic, gastrointestinal and hemostatic dysfunctions. NSAIDs have been widely used for long-term treatment of pain. The effectiveness of carprofen was supported by the larger number of studies, followed by meloxicam and firocoxib. Nevertheless, these can cause certain adverse effects like gastrointestinal, renal and hepatic effects. There is a pharmacokinetic and pharmacodynamic difference between canines and felines that correspond to variance in metabolism. Ibuprofen is not usually recommended for dogs; it can cause ulcers and gastric perforations when therapeutically used, and possibly by many NSAIDs. The objective of this review is to describe the main side effects related to the use of NSAIDs in cats and dogs, to identify and select those that even today can be administered as analgesic and non-steroidal anti-inflammatory for therapeutic purposes in the management of inflammation, pain and fever in the osteoarthritis (OA) in these species to control and care in the dosing intervals.

Keywords : Stomach ulcer; osteoarthritis; pharmacokinetics; renal insufficiency; meloxicam; cyclooxygenase inhibitors (Source: DeCS).

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