Abstract

ROMERO MORENO, Luis Felipe; PARRA-CHARRIS, Juan Sebastián; ANGEL-OBANDO, Ricardo  and  RAMOS-VALENCIA, Liliana. ACCURATE DIAGNOSE AND MANAGEMENT OF ADVANCED NASAL TYPE EXTRANODAL NK/T CELL LYMPHOMA. A CASE REPORT. Case reports [online]. 2017, vol.3, n.1, pp.42-48. ISSN 2462-8522.  https://doi.org/10.15446/cr.v3n1.60912.

Extranodal natural killer (NK)/T-cell lymphoma, nasal type, is a rare entity in otorhinolaryngology. Its management requires skilled physicians in order to suspect this disease and making a proper diagnosis at early stages. This paper reports the case of a 31-year-old male patient, with one month of nasal obstruction, recurrent sinusitis, palatal ulceration and a necrotizing lesion. Histopathology reported lymphoid infiltrate polymorph angiocentric growth pattern and extensive areas of necrosis. Immunohistochemistry confirmed the phenotype for T/NK cells: positive CD3, BCL2, CD4 and CD56. IgG for Epstein-Barr virus was also positive.

The initial staging was T4, N1, M0, Eastern Cooperative Oncology Group (ECOG) scale was 1, with intermediate risk, and low International Prognostic Index (IPI); based on this results, the patient was referred to oncology to initiate treatment. After a ten-month follow-up, the patient's condition improved, with complete remission of nasal and palate injuries; no relapse has occurred to date.

This case is a clear example of the importance of early diagnostic through multiple biopsies in order to establish a specific treatment to decrease complication rates and improve prognosis.

Keywords : Lymphoma, Extranodal NK-T-Cell; Antineoplastic Protocols; Radiotherapy; Granuloma, Lethal Midline [MeSH).

        · text in English     · English ( pdf )