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Revista Colombiana de Nefrología
On-line version ISSN 2500-5006
Abstract
CHACON ACEVEDO, Kelly et al. Efficacy and safety of chloroquine, hydroxychloroquine and azithromycin in patients with COVID-19: Summary of evidence. Rev. colom. nefrol. [online]. 2020, vol.7, suppl.2, pp.21-41. Epub May 08, 2021. ISSN 2500-5006. https://doi.org/10.22265/acnef.7.supl.2.469.
Introduction:
The COVID-19 disease is a health emergency; treatment has not yet been proven.
Objective:
To present the available evidence of efficacy and safety of the use of hydroxychloroquine and azithromycin in the prophylaxis and management of patients with COVID-19.
Methods:
A rapid literature review was performed; we consulted Medline, scopus and pubmed databases.
Results:
Eleven publications were included including rapid literature reviews, observational studies, and clinical trials. No data were found studying prophylaxis with hydroxychloroquine and azithromycin for SARS-CoV-2. Reports of adverse events include episodes of emesis, abdominal pain, nausea, diarrhea, rash, and itching.
Conclusions:
The evidence collected suggests that the use of hydroxychloroquine and azithromycin in patients with COVID-19, could abnormal electrocardiogram and increased risk of mortality in-hospital. The effectiveness remains unclear.
Keywords : COVID-19; hydroxychloroquine; azithromycin; adverse drug event; prophylaxis (MeSH).
