Abstract

ARRIETA BRAVO, Valentina; RANGEL GOMEZ, Tiffany  and  PACHECO LUGO, Lisandro. Exploring the power of transcriptomic approaches to identify biomarkers associated to renal damage in Systemic Lupus Erythematosus patients. Rev. colom. nefrol. [online]. 2021, vol.8, n.1, e304.  Epub Oct 22, 2021. ISSN 2500-5006.  https://doi.org/10.22265/acnef.8.1.492.

Systemic Lupus Erythematosus is a complex and highly heterogeneous disease affecting multiple organs such as joints, heart, hematopoietic system, nervous system and kidney, the latter being the worst prognosis and leading to lupus nephritis (LN). While the etiopathogenesis of SLE is still not completely clear, is believed that genetic susceptibility and aberrant epigenetic modifications favor the outcome of the disease. In order to establish an accurate therapy, it is necessary to efficiently and objectively assess organ involvement and disease activity, which is very difficult due to the clinical laboratory tests currently available. In recent decades, the search for new SLE biomarkers has been a trend and many promising biomarkers have been identified at the genomic, metabolomic, proteomic and transcriptomic levels. In this review we summarize the state of the art related to transcriptomic studies that have identified various potentially useful transcripts as biomarkers of SLE and NL.

Keywords : systemic lupus erythematosus; lupus nephritis; biomarkers; microRNAs..

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