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Revista Colombiana de Nefrología
On-line version ISSN 2500-5006
Abstract
AMADOR CANALS, Annia Cristina et al. Focal segmental glomerulosclerosis of collapsing variant associated with HIV: Clinical case. Rev. colom. nefrol. [online]. 2021, vol.8, n.1, e403. Epub Oct 22, 2021. ISSN 2500-5006. https://doi.org/10.22265/acnef.8.1.514.
Abstract
:
Human immunodeficiency virus infection has changed after the start of highly active antiretroviral treatment, generating greater survival and fewer patient comorbidities. In these patients, the finding of acute renal failure is common, which may be associated with sepsis, drug toxicity, or direct involvement by the virus itself. Nephropathy in patients with HIV infection is varied, where it can be associated with the use of medications or directly due to the effect of the virus (HIVAN). The prevalence is less than 10 % and is characterized by glomerular collapse. Renal parenchyma cells express the chemokine receptors CCR5 and CXCR4 that are essential for the entry of HIV-1 strains into cells. The present case is interesting, since acute renal failure in the framework of a nephrotic syndrome was the first manifestation of a patient with HIV / AIDS.
Keywords : HIV; renal insufficiency; kidney diseases; antiretroviral agents..
