Abstract

TORRES, Rodolfo et al. High transtubular gradient hypokalemia: a practical proposal for its focus. Rev. colom. nefrol. [online]. 2021, vol.8, n.2, e706.  Epub Jan 01, 2022. ISSN 2500-5006.  https://doi.org/10.22265/acnef.8.2.498.

Potassium is a predominantly intracellular ion involved in multiple essential functions to maintain cellular homeostasis. Therefore, its variations at the plasma level are tightly regulated by the renal and the endocrine systems; in addition to being affected by situations such as acidosis, changes in plasma osmolality and concentration of another electrolytes. Hypokalemia is a common electrolyte disorder in clinical practice affected by reporting excessive damage or loss. Its diagnostic approach requires a complete medical record that includes personal pathological and pharmacological information, a specific physical examination with certain conditions like patient’s blood volume and hydration status, as well as the measurement of other electrolytes at the plasma level and occasionally in urine. The transtubular potassium gradient is a useful tool to address possible causes. Bartter syndrome is one of the causes of elevated transtubular gradient hypokalemia.

Keywords : Hypokalemia; Bartter syndrome; Gitelman syndrome..

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