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Revista de la Facultad de Medicina

Print version ISSN 0120-0011

rev.fac.med. vol.66 no.2 Bogotá Apr./June 2018

http://dx.doi.org/10.15446/revfacmed.v66n2.60005 

Original papers

Research on heart failure in Colombia 1980-2015: a systematic review

La investigación en falla cardíaca en Colombia 1980-2015: una revisión sistemática

Juan José Diaztagle-Fernández1  3  *  , Sergio Iván Latorre-Alfonso1  2  , Sebastián Eduardo Maldonado-Arenas1  2  , Gina Paola Manosalva-Álvarez1  2  , Johan Sebastián Merchán-Cepeda1  2  , Carlos David Centeno-García1  2  , Angie Paola Guarín-Castañeda1  2  , Walter Gabriel Chaves-Santiago1  2 

1 Fundación Universitaria de Ciencias de la Salud - Internal Medicine Research Hotbed - Grupo de Investigación Medicina Interna -Bogotá D.C. - Colombia.

2 Hospital de San José - Internal Medicine Service - Bogotá D.C. - Colombia.

3 Universidad Nacional de Colombia - Bogotá Campus - Department of Physiological Sciences - Bogotá D.C. - Colombia.

Abstract

Introduction:

Heart failure is one of the most prevalent diseases worldwide. In Colombia, the state of research on the subject is unknown.

Objective:

To describe the original publications on heart failure in Colombia.

Materials and methods:

Systematic review. Digital search in Embase, PubMed, LILACS and Scielo, using the MeSH terms: "heart failure", "Colombian", "Colombia", "Latin America", "developing countries". Manual search of 58 journals identified in Publindex. Original research that evaluated adult Colombians with heart failure and published between 1980 and 2015 were included.

Results:

2 684 articles were identified, of which 35 met the inclusion criteria. 30 (85.7%) were published since 2009, 30 (85.7%) were conducted in Bogotá and Medellín, 11 (31.4%) had n>200, 19 (54.2%) were descriptive and 5 (14.2%) quasi-experimental. Moreover, 9 (25.7%) described general populations, 9 (25.7%) addressed the issue of self-care, 3 (8.8%) cardiac rehabilitation, 3 (8.8%) perception of the disease and 3 (8.8%) prognostic factors.

Conclusions:

The amount of published original research on heart failure is low, and most of them were carried out recently. Descriptive design was the most frequent, while the most frequently addressed topics were self-care and population descriptions.

Key words: Heart Failure; Research; Colombia; Latin America (MeSH)

Resumen

Introducción.

La falla cardíaca es una de las enfermedades con mayor prevalencia a nivel mundial. En Colombia no se conoce con certeza el estado de la investigación en torno al tema.

Objetivo.

Describir las publicaciones originales en falla cardíaca en Colombia.

Materiales y métodos.

Revisión sistemática. Búsqueda electrónica en Embase, PubMed, LILACS Y SciELO, con términos MeSH: "heart failure", "colombian", "Colombia", "Latin America", "developing countries". Búsqueda manual en 58 revistas identificadas en Publindex. Se incluyeron investigaciones originales, publicadas entre 1980 y 2015, que evaluaron población adulta colombiana con falla cardíaca.

Resultados.

Se identificaron 2 684 artículos: 35 cumplieron criterios de inclusión; 30 (85.7%) fueron publicados a partir del 2009; 30 (85.7%) se realizaron en Bogotá y Medellín; 11 (31.4%) tuvieron n>200; 19 (54.2%) fueron descriptivos y 5 (14.2%) cuasiexperimentales; 9 (25.7%) describieron poblaciones generales; 9 (25.7%) abordaron el tema del autocuidado, 3 (8.8%), la rehabilitación cardíaca, 3 (8.8%), la percepción de enfermedad y 3 (8.8%), los factores pronósticos.

Conclusión.

El número de investigaciones originales publicadas sobre falla cardíaca es escaso; la mayoría se realizó en los últimos años. El diseño descriptivo fue el más común. Los temas abordados con mayor frecuencia fueron el autocuidado y las descripciones poblacionales.

Palabras-clave: Insuficiencia cardíaca; Investigación; Colombia; América Latina (DeCS)

Introduction

Recently, Colombia has presented demographic and epidemiological changes in the population that have determined certain variations in the health profile of its inhabitants. Between 1985 and 2003, a two-fold increase in the number of >60-year-old people and in life expectancy was observed. These changes resulted in a "transitional" epidemiological phase, which led chronic non-communicable diseases to become predominant. For this and other reasons, circulatory system diseases were the leading cause of death by "large groups" in the country between 1997 and 2010, with 28-30% of total deaths. 1 Of these, almost half originated from ischemic heart disease, which is also related to the high prevalence of cardiovascular risk factors such as hypertension, diabetes, smoking, sedentary lifestyle and overweight. 2

Ischemic heart disease, together with hypertensive heart disease, affects cardiac and vascular function, triggering the condition known as heart failure, a chronic disease that progressively deteriorates the health state of the person. Data obtained in the USA indicated that, between 2011 and 2014, the prevalence of heart failure in people aged >20 years was 2.5%, which is equivalent to 6.5 billion people affected. This figure is expected to increase by 46% between 2012 and 2030 3, a situation that requires the use of a high amount of economic resources for the health system. 4 A study conducted in Colombia estimated that the average monthly cost of outpatient treatment in 2010 was COP 304 318 (about USD 160), while the average cost of hospitalization was COP 6 427 887 (about USD 3 387). 5

With this in mind, scientific knowledge on heart failure is fundamental to offer a comprehensive clinical approach and to generate innovation processes around the topic. 6 In Colombia, the current status of research and publication about heart failure is unknown, since knowledge may be limited and publications referring to the topics are scarce. 7 Two national consensuses on acute and chronic heart failure have few citations in the bibliographical references of Colombian works. 7,8 As a result, few published studies or publications may not be adequately known due to various circumstances.

For this reason, the objective of this work is to conduct a systematic review of the literature to identify the publications of studies conducted in our country that address the issue of heart failure, expose their methodological characteristics and the most relevant results, and analyze the data provided by the studies.

Materials and methods

A systematic review of the medical literature published in Colombia on heart failure between 1980 and 2015 was carried out. The following search mechanism was used to identify the articles:

Search in domestic scientific journals: A search was made in Colombian health journals acknowledged by the Sistema Nacional de Indexación y Homologación de Revistas Especializadas de CT+I (National Indexing and Homologation System for Journals Specialized in STI) of Colciencias (National Bibliographic Index-Publindex I- 2013 update) that deal with topics related to clinical medicine. 9 The search in this index was filtered using the so-called Great Knowledge Area: Medical and Health Sciences. With this information, a complete list of the journals used to search for the articles was obtained. In addition, the health journals of the universities that had medical faculties in 2014 were searched in their web pages. Journals where publication of original articles of heart failure was considered unlikely were excluded.

Journals were searched individually, in their respective website, identifying the issues published between January 1980 and December 2015. The table of contents of said issues was analyzed, and articles related to heart failure were verified. Inclusion and exclusion criteria were applied to the articles initially identified. In case that the online version of the issues was not found in its entirety, a manual search was carried out in different libraries and national newspaper archives.

Digital search in databases: A digital search was carried out in the Embase, PubMed and Lilacs databases and in the Cochrane Library, using the search structure described in Annex 1. Manual search of bibliographic references: A manual search was made of the references of all the articles identified in the three previous searches, applying inclusion and exclusion criteria.

Review of CvLac resumes of the main authors: A search of the resumes of the main authors of the identified articles was made on CvLac to verify the existence of additional articles. Inclusion and exclusion criteria of articles: Original research on patients >18 years of age, diagnosed with acute or chronic heart failure, outpatient or inpatient in Colombia, published in full text, with an observational intervention design or clinical simulation model were included. Case reports, subject reviews, management guidelines and articles published only in summary version were excluded from the analysis.

A data collection tool was designed to carry out the bibliographic documentation, which included the affiliation data of the journal, the type of article described along with the year, issue, number and title of the document. Information on the methodological characteristics of the study, the results and the conclusions of the selected articles was also obtained. The study was approved by the Human Research Ethics Committee of the Hospital of San José of Bogotá and the Fundación Universitaria de Ciencias de la Salud.

Results

Search result

Search in domestic scientific journals: A search of journals was carried out on February 23, 2014 in the National Bibliographic Index-Publindex I-2013 update of the official web page of Colciencias. 73 records were obtained (58 in clinical medicine, 25 in health sciences, 14 in other medical sciences and 3 in basic medicine). Of the total journals identified, 58 were selected to conduct the review. The journal identification process is described in Annex 1. Table 1 shows general information of these journals.

Of 58 journals, 26 were published in full text in an online version. For the remaining 32, it was necessary to complement the search in university and national libraries. It was also necessary to contact editors and administrative staff of some journals to obtain missing issues.

All the issues of 56 journals were reviewed in their entirety. After reviewing all the articles in these issues, 87 studies were found that dealth with heart failure as a central topic, of which 31 met inclusion criteria (Figure 1).

Table 1 Description of selected journals. 

Source: Own elaboration based on the data obtained in the study.

Source: Own elaboration based on the data obtained in the study.

Figure 1 Flowchart of literature search and study selection. 

Digital search in databases: This search allowed to identify 2 597 records, of which 16 met the inclusion criteria. Of these, 12 had already been identified in the manual search (Figure 1). Annex 2 describes the digital search strategy. No additional articles were found after searching references and CvLac resumes.

Analysis of identified studies

Of 35 studies published (5,10-43), the largest number (25.7%) was found in the Revista Colombiana de Cardiología with 9, followed by Acta Médica Colombiana with 7 (20%) (Figure 2). The cities with the highest number of publications on heart failure were Bogotá and Medellín, with 15 studies each (42.8%) (Figure 3), and the largest number of publications (85.7%) was observed in 2009 (Figure 4).

Source: Own elaboration based on the data obtained in the study.

Figure 2 Number of articles per journal. 

Source: Own elaboration based on the data obtained in the study.

Figure 3 Number of articles per city. 

Source: Own elaboration based on the data obtained in the study.

Figure 4 Number of articles per year of publication. 

Regarding methodological aspects, 19 (54.2%) studies were descriptive and 5 (14.2%) quasi-experimental. In 13 (37.1%), the sample size was <50, 11 (31.4%) had >200 patients and 9 (25.7%) described general populations (Tables 2-4). On the other hand, 9 studies (25.7%) addressed self-care, 3 (8.8%) evaluated prognostic factors and aspects of cardiac rehabilitation, while 2 evaluated issues related to disease perception, nutritional aspects and therapeutic interventions. No studies related to prevention or treatment for stages I to III, according to the classification of the New York Heart Association (NYHA), were found (Tables 2-4).

Table 2 Observational studies that described populations or established causal relationships with various endpoints in outpatient and inpatient settings. 

HF: Heart Failure; IH: In-hospital; BMI: Body Mass Index; HBP: High blood preasure; Hb: Hemoglobin; NYHA: New York Heart Association; EF: ejection fraction; EFLV: Ejection fraction of the left ventricle; AH: Arterial Hypertension; DM2: Diabetes mellitus tipo 2; FC: Functional Classification; OR: Odds Ratio; CAD: Coronary artery disease; ACEI: Angiotensin converting enzyme inhibitors; ARB: Angiotensin II receptor blockers; BB: Beta blockers; HS: Hospital stay; HR: Heart rate; ACS: Acute coronary syndrome; BNP: Brain natriuretic peptide; BUN: Blood Urea Nitrogen; NT-ProBNP: N-terminal prohormone of brain natriuretic peptide; ICD: Implantable Cardioverter Defi-brillator; COPD: Chronic obstructive pulmonary disease; VO2max: maximum oxygen consumption; GWTH-HF: Get With The Guidelines-Heart Failure

Source: Own elaboration based on the data obtained in the study.

Table 3 Studies related to interventions or costs. 

HF: Heart Failure; NYHA: New York Heart Association; FC: Functional Classification; EF: Ejection fraction; NT-ProBNP: N-terminal prohormone of brain natriuretic peptide; VO2: Volume of oxygen; MET: Metabolic equivalent of task; COP: Colombian pesos, HS: Hospital stay; RCT: Randomized clinical trial; NNT: Number needed to treat; AH: Arterial hypertension.

Source: Own elaboration based on the data obtained in the study.

Table 4 Observational studies that assessed self-care or patient perception. 

HF: Heart Failure; NYHA: New York Heart Association; FC: Functional Classification; AH: Arterial Hypertension; EF: Ejection fraction; CAD: Coronary artery disease.

Source: Own elaboration based on the data obtained in the study.

One of the most relevant results was related to in-hospital mortality, with a rate of 3.8-28.6% 10-13,16,17,19,32; one study reported a rate of 13.8% of mortality at one month of and 45.2% at one year. 12 Furthermore, three studies reported data on median hospital stay, which was between 6-10 days 13,17,19; other three studies reported hospital re-admissions rates of 24.5%, 40.8% and 84.3% at one year 13,21,19, and another reported 23.8% re-admission rates at two months. 32 Some studies evaluated specific comorbidities, documenting a high presence of abnormalities in nutritional parameters 10, cardio-renal anemia 15, kidney failure 22, affective disorders 23 and musculoskeletal pathologies. 27

With reference to interventions, two studies showed the beneficial effects of cardiac rehabilitation plans on patients 30,31, while four others showed an improvement in adherence to management or self-care by patients when performing interventions or educational plans led by nursing. 29,33-35

An important percentage of works were developed by nursing professionals; 9 (25.7%) corresponded to self-care behavior interventions and adherence to medical treatment for heart failure in quasi-experimental studies in patients.

Discussion

The main motivation to carry out this research was the need to identify domestic studies on heart failure within the framework of the discussions generated based on academic work developed by our institution around this issue. Initial observations of references of domestic guidelines, texts or review articles showed few citations of original studies; therefore, establishing the actual amount of this type of publications and the topics treated was considered important.

The results of this research show that, in fact, there are few studies published based on the observation period, although the number of publications has increased recently. Likewise, almost all designs were observational and only one was a randomized clinical trial. It is important to highlight the lack of the latter design, which offers important results from the point of view of "evidence-based medicine" when evaluating medical interventions.

In Colombia, several investigations have been carried out with the objective of evaluating scientific production in the health area. Jaramillo-Salazar et al.44 evaluated clinical research in the country based on the scientific production recorded in the Thomson-ISI database between 1975 and 2005, while Alvis-Guzmán & De la Hoz 45 analyzed the publications in Medline and LILACS databases in the period between 1993 and 2003. In both studies, there is a significant and progressive increase in the number of publications after the 1990s.

In this study, an increasing number of publications in the last five years was observed. It is important to note that, in the aforementioned research, the number of publications in basic sciences increased more than in clinical areas and, among them, tropical medicine, neurosciences and infectious diseases were the most common. 45 Therefore, the reduced amount of publications on heart failure in the 1990s is related to a lowest amount of publications in the area of clinical medicine in general.

Most of the works were published in Bogotá and Medellín. This is consistent with other reports in health sciences in general, although cities such as Cali provide a significant number of publications in other areas of biomedical research. 45-47

Among journals evaluated, the Revista Colombiana de Cardiología journal had the highest number of publications, followed by Acta Médica Colombiana, which is an expected result. However, a significant number of articles were found in journals edited by universities. At this point, it is worth noting that, several of these journals are indexed in Latin American databases such as LILACS or Redalyc, and even some in international databases, but not all of them are, which makes it difficult to access their articles. This was one of the reasons why the digital search did not identify the total number of articles published, leaving manual search as the only option to identify them. This reinforces the importance of quality improvement processes in the journals, highlighted by various editors, to allow them to access international databases and achieve better scientific positioning. 48-51

Research carried out by nursing professionals deserves special attention, since they contributed a good number of publications focused on self-care and some used qualitative methodology. This allowed obtaining valuable results that must be taken into account when comprehensively approaching the patient. The investigated issues are, in addition to the ones mentioned above, general description studies in inpatient and outpatient populations with heart failure, including studies on prevalence of specific comorbidities such as malnutrition and kidney failure. Although they are few, they offer relevant data on intra-hospital mortality, prevalence of comorbidities and treatment of this disease.

When reviewing Latin American literature, reviews on heart failure that cite studies that address epidemiological, diagnostic and therapeutic aspects were found, especially in Brazil, Chile, Argentina and Mexico. 52-54 Argentina and Chile have national records 55,56 important to evaluate the behavior of the disease in the "real world". 57 Currently, Colombia does not have information on published records of heart failure. With some frequency, the country's institutions have been part of international studies that have evaluated multiple cardiovascular issues 58-62; however, specific data on the Colombian population are not always widely disseminated since there are no specific publications, which would represent a valuable contribution to the knowledge of our patients. The I PREFER record is one of the cases with this kind of publications. 33,63

It has been established that research should fulfill two important functions. On the one hand, it should make an academic impact, which implies that research should be made public and discussed by the academic community involved and that it should be published in scientific journals, a fundamental part of the process. 64 The objective is to transcend the context of undergraduate and postgraduate programs and conference summaries. In the same way, once published, it should be identified and read by the actors of the community in question. Improving the visibility of published articles and generating an academic discussion around them is a challenge for all people involved in research and teaching processes in health. In this regard, citing more frequently and using domestic investigations as part of discussions of research articles is one of the tasks that should be given more attention. 48

On the other hand, research should fulfill a social function that occurs when scientific knowledge achieves a benefit for society in general. Therefore, domestic scientific production should be considered when creating social impact policies in a given area. 6,65 In this regard, several studies have been conducted that raise the importance of using the results of research in decision making.

Mosquera et al.66 established that the results of domestic studies did not guide public health decision-making in a departmental health ministry of Colombia and stated that one of the main barriers is the lack of policies and structure for the management of the investigative process. On the other hand, Gómez et al.67 concluded that the potential influence of research on policy decisions depends on multiple factors, some of which may be "governable" by researchers, and stressed the importance of promoting greater contact with decision makers.

The Colombian population has different biological and social realities with respect to cardiovascular risk 68,69, as shown by studies carried out in Latin America; in consequence, it is essential to generate domestic knowledge. While it is true that participation in international research networks is important for strengthening the different scientific groups of the country, strengthening our own work agenda is no less important to enlighten and help provide solutions to our problems. 70,71

From the academy, validation and local legitimization mechanisms of knowledge application processes that serve to consolidate the scientific tradition of the nation should be sought, without giving so much priority to the "centers of knowledge" that are often seen as models for local scientific activities. 72,73 The idea that "the interpretation of our reality with alien schemes only contributes to making us increasingly unknown, increasingly less free and increasingly lonely" remains valid. 74

One of the limitations of this review is that it included articles published since 1980, which did not allow identifying articles published prior to this date. However, few Colombian journals began publishing earlier. The review was limited to published studies and did not include results of abstracts or thesis, considered as products of research processes. Abstracts were excluded taking into account that many times they do not provide the data necessary to carry out a complete analysis of the research, while theses were discarded mainly because a systematic way for searching was not identified and, at the moment of carrying out the research, not all universities had a standardized form of thesis file. This undoubtedly generates a potential publication bias, inherent to the research itself. The main strength of this study was that a manual review was carried out which allowed to identify articles that were not found with a digital search.

Conclusion

The amount of original investigations published on heart failure is scarce; most of them were conducted recently, almost all in domestic journals. Descriptive design was the most common form, and the most frequently addressed subjects were self-care and population descriptions.

Acknowledgments

To Carlos Castro, coordinator of the research hotbed of Fundación Universitaria de Ciencias de la Salud. To John Jaime Sprockel, instructor, Fundación Universitaria de Ciencias de la Salud, and to Diana Buitrago, instructor in the Research Division, Fundación Universitaria de Ciencias de la Salud.

Note: This article is the result of a research project carried out by the Internal Medicine Research Hotbed and the Internal Medicine Research Group of the Fundación Universitaria de Ciencias de la Salud.

References

1. Colombia. Ministerio de Salud y Protección Social. Plan Decenal de Salud Pública 2012-2021. Bogotá D.C.: MinSaliud; 2013 [cited 2014 Jul 12]. Available from: Available from: https://goo.gl/BwHFRK . [ Links ]

2. Colombia. Ministerio de la Protección Social. Universidad de Antioquia. Facultad Nacional de Salud Pública. Análisis de la situación de salud en Colombia 2002-2007. Tomo III: Morbilidad y mortalidad de la poblacion colombiana. Bogotá D.C.; Ministerio de Protección social. 2010 [cited 2014 Jul 12]. Available from: Available from: https://goo.gl/QRXYa3 . [ Links ]

3. Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart Disease and Stroke Statistics-2017 Update: A report From the American Heart Association. Circulation. 2017;135(10):e146-e603. http://doi.org/cck5. [ Links ]

4. Feitell S, Hankins SR, Eisen HJ. Adjunctive Therapy and Management of the Transition of Care in Patients with Heart Failure. Cardiol. Clin. 2014;32(1):163-74. http://doi.org/chkn. [ Links ]

5. Tamayo DC, Rodríguez VA, Rojas MX, Rincón M, Franco C, Ibarra MT, et al. Costos ambulatorios y hospitalarios de la falla cardiaca en dos hospitales de Bogotá. Acta Med. Colomb. 2013;38(4):208-12. [ Links ]

6. Ramírez-Martínez DC, Martínez-Ruiz LC, Castellanos-Domínguez OF. La comunicación científica. In: Divulgación y difusión del conocimiento científico: las revistas científicas. Bogotá D.C: Grupo de Investigación y Desarrollo en Festión, Productividad y Competitividad (BoiGestión),;2012. p. 25-48. [ Links ]

7. Gómez E, Atehortúa L, editors. Guías colombianas de cardiologia. Tratamiento de la falla cardíaca aguda. Rev. Colomb. Cardiol. 2011;18(Suppl 2):165-99. [ Links ]

8. Sociedad Colombiana de Cardiología y Cirugía Cardiovascular. Consenso colombiano para el diagnóstico y tratamiento de la Insuficiencia cardíaca crónica. Bogotá D.C.; 2014. [ Links ]

9. Sistema Nacional de Indexación Y Homologación de Revistas Especializadas de CT-I. Publindex. Bogotá D.C.. Colciencias; 2014. [cited 2014 apr 11]. Available from: Available from: https://goo.gl/TJpp9T . [ Links ]

10. Plata LG, Angel LA. Prevalencia de la desnutrición en pacientes con insuficiencia cardíaca congestiva y su influencia en la mortalidad. Rev. Fac. Med. 1994;42(4):197-202. [ Links ]

11. Ospina-Serrano AV, Gamarra-Hernandez G. Características clínicas y epidemiológicas de la insuficiencia cardiaca en el Hospital Universitario Ramón González Valencia de Bucaramanga, Colombia. Salud UIS. 2004;36:125-31. [ Links ]

12. Lancheros A, Valencia Y, Chaves SW. Insuficiencia cardiaca aguda: factores asociados con mortalidad. Repert. med. cir. 2009;18(3):166-74. [ Links ]

13. Henao C, Benavides-Bermúdez JM, Chaves W, Diaztagle JJ, Sprockel J, Hernández JI. Falla cardiaca descompensada: estratificación del riesgo de mortalidad intrahospitalaria Hospital de San José de Bogotá D.C. Repert. med. cir. 2011;20(4):251-58. [ Links ]

14. Senior JM, Saldarriaga C, Rendón J. Descripción clínico-epidemiológica de los pacientes con falla cardiaca aguda que consultan al servicio de urgencias. Acta Med. Colomb. 2011;36(3):125-29. [ Links ]

15. Ramírez JD, Saldarriaga CI, Cardona MC, Aristizábal F, Bahamón CM, Ocampo M, et al. Síndrome de anemia cardiorrenal. Estudio de casos y controles anidado en una cohorte. Acta Med. Colomb. 2013;38(1):7-11. [ Links ]

16. Chaves WG, Diaztagle JJ, Vargas V, Mejía MG, Sprockel JJ, Hernández JI. Cumplimiento de guías en pacientes hospitalizados con falla cardiaca ¿Cómo estamos? Acta Med. Colomb. 2014;39(1):40-5. [ Links ]

17. Chaves WG, Diaztagle JJ, Sprockel JJ, Hernández JI, Benavidez JM, Henao DC, et al. Factores asociados a mortalidad en pacientes con falla cardiaca descompensada. Acta Med. Colomb. 2014;39(4):314-20. [ Links ]

18. Saldarriaga C, Gonzáles N, Ávila A. Diferencias de género en el tratamiento de la falla cardíaca. Rev. Col. Cardiol. 2014;21(1):27-32. http://doi.org/f2tc75. [ Links ]

19. Ocampo-Chaparro JM, Badiel M, Casanova ME, Reyes-Ortiz CA, León-Giraldo H, Castaño-Cifuentes O. Características clínicas y supervivencia a 30 días de pacientes ancianos colombianos hospitalizados por insuficiencia cardíaca descompensada. Rev. Esp. Geriatr. Gerontol. 2015;50(3):153-5. http://doi.org/f2572p. [ Links ]

20. Marín JE, Duque M, Medina LE, Uribe W, Echavarría E, Marín GJ, et al. Utilidad del péptido natriurético cerebral en la evaluación de pacientes con falla cardiaca tratados con resincronización cardiaca y su correlación con la evolución clínica. Rev. Col. Cardiol. 2007;14:133-49. [ Links ]

21. Castaño-Castrillón J, Giraldo JF, Herrera HD, Jaramillo-Jimenez J, Noreña-Villada JM, Restrepo M. Caracterización de pacientes con insuficiencia cardiaca en el primer nivel de atención de la ciudad de Manizales (Colombia) 2005-2008. Arch. Med. 2010;10(2):127-38. [ Links ]

22. Rodríguez D, Gómez E. Prevalencia de insuficiencia renal en pacientes que asisten a la clínica de falla cardiaca. Rev. Col. Cardiol. 2011;18:144- 53. http://doi.org/f2tdgf. [ Links ]

23. Torres-Navas A, Sierra-Camargo A, Mora-Chaparro B, Durán-Flórez E, Ibáñez-Palacios M. Influencia de los factores psicosociales sobre el estado clínico de pacientes con insuficiencia cardíaca crónica manejados en una unidad multidisciplinaria. Revista Salud Bosque. 2011;1(1):9-16. [ Links ]

24. Gómez EA. Identificación de pacientes con falla cardiaca y función sistólica preservada: Un estudio epidemiológico regional (I-PREFER Study) - Colombia. Rev. Colomb. Cardiol. 2013;2:58-67. http://doi.org/f2tc8d. [ Links ]

25. Arango-Franco R, Martínez JW, Cárdenas-Cárdenas JM, Rivera-Toquica AA, Marín-Medina DS, Orozco-Hernández JP, et al. Falla cardíaca avanzada en pacientes tratados con dispositivos electro-fisiológicos en una unidad de electrofisología, Pereira (Colombia). Rev. Investigaciones Andina. 2014;28(16):978-88. [ Links ]

26. Triviño L, Ávila JC, Ramírez-Vélez R. La paradoja de la obesidad y su relación con la aptitud cardiorrespiratoria en pacientes con insuficiencia cardiaca. Rev. Col. Cardiol. 2015;22(5):218-23. http://doi.org/f3g7nm. [ Links ]

27. Senior JM, Plata JA, Navas CM. Prevalencia de patología musculoes-quelética asociada al síndrome de falla cardiaca. Acta Med. Colomb. 2014;39(3):233-7. [ Links ]

28. Núñez F, Sandoval N, Caicedo V, Velasquez O, Orjuela H, Santos H, et al. Nuevas alternativas quirúrgicas al trasplante cardiaco para pacientes en estado terminal con insuficiencia cardiaca. Rev. Col. Cardiol. 2002;10(1):32-46. [ Links ]

29. Achury-Saldaña DM. Autocuidado y adherencia en pacientes con falla cardiaca. Aquichan. 2007;7(2):139-60. [ Links ]

30. Atehortúa DS, Gallo JA, Rico M, Durango L. Efecto de un programa de rehabilitación cardiaca basado en ejercicio sobre la capacidad física, la función cardiaca y la calidad de vida, en pacientes con falla cardiaca. Rev. Col. Cardiol. 2011;18(1):25-36. http://doi.org/f2tdcc. [ Links ]

31. Quiroz CA, Sarmiento J, Jaramillo C, Sanabria A. Impacto de la rehabilitación cardiaca en pacientes con falla cardiaca de origen isquémico. Rev. Col. Cardiol. 2011;18(1):10-24. http://doi.org/f2tdcf. [ Links ]

32. Senior JM, Saldarriaga CI, Aristizábal JM, Rendón JA. Seguridad y eficacia de la utilización de levosimendán sin dosis de carga en una unidad de falla cardiaca especializada. Acta Med. Colomb. 2011;36(2):68-72. [ Links ]

33. Arredondo-Holguín E, Rodríguez-Gázquez MA, Higuita-Urrego L. Mejoramiento en los comportamientos de autocuidado después de una intervención educativa de enfermería con pacientes con falla cardíaca. Invest. Educ. Enferm. 2012;30(2):188-97. [ Links ]

34. Rodríguez-Gázquez Mde L, Arredondo-Holguín E, Herrera-Cortés R. Efectividad de un programa educativo en enfermería en el autocuidado de los pacientes con insuficiencia cardíaca. Ensayo clínico controlado. Rev. Latino Am. Enfermagem. 2012;20(2):1-11. http://doi.org/chkr. [ Links ]

35. Camargo-Rojas C, Córdoba-Rojas DN, Guío-Reyes AM. La entrevista motivacional como intervención de enfermería para promover el autocuidado en pacientes con insuficiencia cardíaca en una institución de cuarto nivel en Bogotá, Colombia. Investig. Enferm. Imagen Desarr. 2013;15(1):31-49. [ Links ]

36. Romero M, Arango C. Análisis de costo efectividad del uso de metoprolol succinato en el tratamiento de la hipertensión arterial y la falla cardíaca en Colombia. Rev. Col. Cardiol. 2012;19(4):160-8. http://doi.org/f2tdcw. [ Links ]

37. Arredondo-Holguín E. Comportamientos y capacidad de agencia de autocuidado de adultos con insuficiencia cardiaca. Av. enferm. 2010;28(1):21-30. [ Links ]

38. Uribe M, Muñoz C, Restrepo J, Zapata A. Percepción del paciente hospitalizado por falla cardiaca. Institución de salud 2009. MEDICINA UPB. 2010;29(2):124-34. [ Links ]

39. Zapata-Gómez NE. La experiencia de sufrir una insuficiencia cardiaca crónica: Un padecimiento que acerca a la muerte. Invest. Educ. Enferm. 2011;29(3):419-26. [ Links ]

40. Achury-Saldaña DM, Sepúlveda-Carrillo GJ, Rodríguez-Colmenares SM, Giraldo IC. Validez y confiabilidad de un instrumento evaluativo de adherencia en pacientes con falla cardíaca. Enferm. Glob. 2012;11(26):1-9. http://doi.org/chkv. [ Links ]

41. Rodríguez-Gázquez M, Arredondo-Holguín E. Validez y confiabilidad de una escala de valoración de comportamientos de autocuidado en personas con falla cardiaca. Aquichan. 2012;12(1):22-31. [ Links ]

42. Rodríguez-Gázquez Mde L, Arredondo-Holguín E, Salamanca-Aze-vedo YA. Capacidad de agencia de autocuidado y factores relacionados con la agencia en personas con falla cardíaca de la ciudad de Medellín (Colombia). Enferm. Global. 2013;12(2):183-95. http://doi.org/chkx. [ Links ]

43. Arredondo-Holguín E, Rodríguez-Gázquez Mde L, Higuita-Urrego LM. Dificultades con la adherencia al tratamiento no farmacológico de pacientes con falla cardiaca detectados a través de seguimiento telefónico. Investig. Enferm. Imagen Desarr. 2014;16(2):133-147. http://doi.org/chkz. [ Links ]

44. Jaramillo-Salazar H, Latorre-Santos C, Albán-Conto C, Lopera-Oquendo C. Caracterización de la investigación clínica en Colombia a partir de la producción científica de salud: base de datos Thomson-ISI 1975-2005. In: El hospital como organización de conocimiento y espacio de investigación y formación. Bogotá D.C.: Editorial Universidad del Rosario;. 2008. p.37-50. [ Links ]

45. Alvis-Guzmán N, De La Hoz-Restrepo F. Producción Científica en Ciencias de la Salud en Colombia, 1993-2003. Rev. Salud Pública. 2006;8(1):25-37. [ Links ]

46. Rodríguez-Morales AJ, Rendón MA. Situación de la investigación y publicación científica en Colombia y en el departamento de Risaralda: Revisión de indicadores en el contexto de la creación de la Oficina de Investigación Científica de COODESURIS. Revista Médica de Risaralda. 2012;18(1):72-82. [ Links ]

47. Rosselli-Cock DA. La investigación biomédica en Colombia: Un análisis de Medline. Colombia Med. 1998;29(3):108-111. [ Links ]

48. Matijasevic E. Acta Médica Colombiana y las fuerzas de producción social. Acta Med. Colomb. 2010;35(3):107-112. [ Links ]

49. Alfonso F, Almonte K, Arai K, Bacal F, Drago-Silva JM, Galeano-Figueredo J, et al. Revistas cardiovasculares iberoamericanas. Propuestas para una colaboración necesaria. Rev. Esp. Cardiol. 2009;62(9):1060-7. http://doi.org/b5z6t7. [ Links ]

50. Rojas M, León-Galindo J, Echeverri D. Las bases de datos: un instrumento fundamental. Rev Col. Cardiol. 2012;19(3):105-8. http://doi.org/f2tdbs. [ Links ]

51. Caballero-Uribe CV, Alonso-Palacio LM. Salud Uninorte inicia la era del Open Journal System (OJS). Salud Uninorte. 2010;26(1):i-iv. [ Links ]

52. Hernández-Leiva E. Epidemiology of acute coronary syndrome and heart failure in Latin America. Rev. Esp. Cardiol. 2011;64(Suppl 2):34-43. doi: http://doi.org/ddfdnv. [ Links ]

53. Bocchi EA, Arias A, Verdejo H, Diez M, Gómez E, Castro P. The Reality of Heart Failure in Latin America. J. Am. Coll. Cardiol. 2013;62(11):949-58. http://doi.org/f2fnwf. [ Links ]

54. Cubillos-Garzón LA, Casas JP, Morillo CA, Bautista LE. Congestive heart failure in Latin America: the next epidemic. Am. Heart J. 2004;147(3):412-7. http://doi.org/fpsvrs. [ Links ]

55. Castro P, Verdejo H, Vukasovic JL, Garcés E, González. Predictores de mortalidad intrahospitalaria y hospitalización prolongada en la insuficiencia cardíaca: resultados preliminares del registro nacional de insuficiencia cardíaca. Grupo ICARO. Rev. Med. Chile. 2006;134(9):1083-91. http://doi.org/bxdhpj. [ Links ]

56. Fairman E, Thierer J, Rodríguez L, Blanco P, Guetta J, Fernández S, et al. Registro Nacional de Internación por Insuficiencia Cardíaca 2007. Rev. Argent. Cardiol. 2009;77(1):33-9. [ Links ]

57. Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J. Am. Coll. Cardiol. 2014;63(12):1123-33. http://doi.org/f2q42v. [ Links ]

58. Schargrodsky H, Hernández-Hernández R, Champagne B, Silva H, Vinueza R, Silva-Ayçaguer LC, et al. CARMELA: Assessment of Cardiovascular Risk in Seven Latin American Cities. Am. J. Med. 2008;121(1):58-65. http://doi.org/db4rmz. [ Links ]

59. Miranda JJ, Herrera VM, Chirinos JA, Gómez LF, Perel P, Pichardo R, et al. Major cardiovascular risk factors in Latin America: a comparison with the United States. The Latin American Consortium of Studies in Obesity (LASO). PLoS One. 2013;8(1):e54056. http://doi.org/f432cg. [ Links ]

60. Yusuf S, Rangarajan S, Teo K, Islam S, Li W, Liu L, et al. Cardiovascular Risk and Events in 17 Low-,Middle-, and High-Income Countries. N. Engl. J. Med. 2014;371(9):818-27. http://doi.org/xcq. [ Links ]

61. Lanas F, Avezum A, Bautista LE, Diaz R, Luna M, Islam S, et al. Risk Factors for Acute Myocardial Infarction in Latin America: The INTERHEART Latin American Study. Circulation. 2007;115(9):1067-74. http://doi.org/ctkjzt. [ Links ]

62. Isaza D, Valenzuela D, Plata E. ACCES: Encuesta de estrategia de manejo en síndrome coronario agudo (SCA). Resultados de los 12 meses de seguimiento en la población de Colombia comparada con Latinoamérica. Rev. Col. Cardiol. 2012;19(Suppl 1):35. [ Links ]

63. Magaña-Serrano JA, Almahmeed W, Gomez E, Al-Shamiri M, Adgar D, Sosner P, et al. Prevalence of heart failure with preserved ejection fraction in Latin American, Middle Eastern, and North African Regions in the I PREFER study (Identification of Patients With Heart Failure and PREserved Systolic Function: an epidemiological regional study). Am. J. Cardiol. 2011;108(9):1289-96. http://doi.org/cdhfv8. [ Links ]

64. Martínez-López E. Publicar, ¿para qué? Rev. Fac. Nac. Salud Pública. 2005;23(1):1. [ Links ]

65. Rodriguez-Gázquez M. La transferencia de los resultados de investigación y la generación de bienestar social. MEDICINA UPB. 2010;29(2): 85-6. [ Links ]

66. Mosquera J, Gómez OL, Méndez F. Uso de los resultados de las investigaciones en salud pública en una entidad territorial de salud en Colombia. Colomb. Med. 2005;36(1):16-22. [ Links ]

67. Gómez RD, Orozco DA, Rodríguez FL, Velásquez W. Políticas públicas y salud: relación entre investigación y decisión. Rev. Fac. Nac. Salud Pública. 2006;24(2):105-118. [ Links ]

68. López-Jaramillo P. La epidemia de las enfermedades cardiometabólicas en Latinoamérica: características diferentes que requieren acciones particulares. Rev. Col. Cardiol. 2008;15(4):153-60. [ Links ]

69. López-Jaramillo P, López-López J. Lecciones aprendidas de dos grandes estudios epidemiológicos de enfermedades cardio-cerebrovasculares en las que ha participado Colombia. Rev. Col. Cardiol. 2010;17(5):195-200. http://doi.org/f2tdfv. [ Links ]

70. Martínez-Herrera E. La gestión del conocimiento en políticas públicas en salud y participación social. CES Medicina. 2007;21(1):101-8. [ Links ]

71. Martínez E, Franco DF, Villa L. Las redes de conocimiento en salud pública y el fortalecimiento de capacidades a través de estrategias de cooperación. Rev. Fac. Nac. Salud Pública. 2009;27(3):349-55. [ Links ]

72. Chambers DW. Locality and Science: Myths of Centre and Periphery. In: Lafuente A, Elena A, and Ortega M, editors. Mundialización de la ciencia y la cultura nacional. Madrid: Doce Calles, 1993. p. 605-617. [ Links ]

73. Restrepo-Forero OM. "La mundialización del Darwinismo como proceso y como texto". Acta biol. Colomb. 2009;14(4S):41-62. [ Links ]

74. García-Márquez G. Nobel Lecture: La soledad de América Latina. Nobelprize.org. 2004. [cited 2017 Dec 18]. Available from: Available from: https://goo.gl/scjRRk . [ Links ]

Diaztagle-Fernández JJ, Latorre-Alfonso SI, Maldonado-Arenas SE, Manosalva-Álvarez GP, Merchán-Cepeda JS, Centeno-García CD,et al. Research on heart failure in Colombia 1980-2015: a systematic review. Rev. Fac. Med. 2018;66(2):139-51. English. doi: http://dx.doi.org/10.15446/revfacmed.v66n2.60005.

Diaztagle-Fernández JJ, Latorre-Alfonso SI, Maldonado-Arenas SE, Manosalva-Álvarez GP, Merchán-Cepeda JS, Centeno-García CD,et al. [La investigación en falla cardíaca en Colombia 1980-2015: una revisión sistemática]. Rev. Fac. Med. 2018;66(2):139-51. English. doi: http://dx.doi.org/10.15446/revfacmed.v66n2.60005.

Conflicts of interests None stated by the authors.

Funding This work was funded through the internal call No. 19-3739-2 of 2013 of the Fundación Universitaria de Ciencias de la Salud and the national call of Colciencias No. 617 of 2013, chapter Hotbed-Young Researchers.

Annex 1

Table A1. Journals of the national bibliographic index-IBN Publindex I 2013 update included for review. 

Source: Own elaboration based on the data obtained in the study.

Table A2. Journals identified when searching for medical faculties not included in the Publindex list. 

Source: Own elaboration based on the data obtained in the study.

Table A3. Excluded journals. 

Source: Own elaboration based on the data obtained in the study.

Annex 2.

Table A4. Search strategy - heart failure 1980-2015. 

Source: Own elaboration based on the data obtained in the study.

MEDLINE - PUBMED

#24,"Search (((((((((heart failure) OR ""Heart Failure""[Mesh]) OR ""Heart Failure, Diastolic""[Mesh]) OR ""Heart Failure, Systolic""[Mesh]) OR chronic heart failure) OR decompensated heart failure) OR acute heart failure) OR congestive heart failure)) AND (((((((colombia) OR ""Colombia""[Mesh]) OR colombian) OR latin america) OR ""Latin America""[Mesh]) OR developing countries) OR ""Developing Countries""[Mesh]) Filters: Publication date from 1980/01/01 to 2015/12/31",583,05:56:29 #23,"Search (((((((((heart failure) OR ""Heart Failure""[Mesh]) OR ""Heart Failure, Diastolic""[Mesh]) OR ""Heart Failure, Systolic""[Mesh]) OR chronic heart failure) OR decompensated heart failure) OR acute heart failure) OR congestive heart failure)) AND (((((((colombia) OR ""Colombia""[Mesh]) OR colombian) OR latin america) OR ""Latin America""[Mesh]) OR developing countries) OR ""Developing Countries""[Mesh])",625,05:56:05 #22,"Search ((((((colombia) OR ""Colombia""[Mesh]) OR colombian) OR latin america) OR ""Latin America""[Mesh]) OR developing countries) OR ""Developing Countries""[Mesh]",140910,05:55:26

#21,"Search ""Developing Countries""[Mesh]",65910,05:54:48

#19,"Search developing countries",112295,05:54:27

#18,"Search ""Latin America""[Mesh]",9188,05:54:07

#16,"Search latin america",17320,05:53:43

#15,"Search colombian",3352,05:53:24

#14,"Search ""Colombia""[Mesh]",7062,05:53:07

#12,"Search colombia",19143,05:52:41

#11,"Search (((((((heart failure) OR ""Heart Failure""[Mesh]) OR ""Heart Failure, Diastolic""[Mesh]) OR ""Heart Failure, Systolic""[Mesh]) OR chronic heart failure) OR decompensated heart failure) OR acute heart failure) OR congestive heart failure",199172,05:52:07

#10,"Search congestive heart failure",199172,05:51:10

#9,"Search acute heart failure",32613,05:50:53

#8,"Search decompensated heart failure",3316,05:50:33

#7,"Search chronic heart failure",199172,05:50:11

#6,"Search ""Heart Failure, Systolic""[Mesh]",984,05:49:40

#5,"Search ""Heart Failure, Diastolic""[Mesh]",605,05:49:09

#4,"Search ""Heart Failure""[Mesh]",97207,05:48:48

#3,"Search heart failure",199172,05:48:18

EMBASE-ELSEVIER

#20 #11 AND #18 AND [1980-2015]/py 1,069

#19 #11 AND #18 1,182

#18 #12 OR #13 OR #14 OR #15 OR #16 OR

#17 163,154 #17 'developing country' 86,377

#16 'developing countries' 53,990

#15 'south and central america' 14,529

#14 'latin america' 13,750

#13 'colombian' 4,405

#12 'colombia' 36,247

#11 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 299,896

#10 'congestive heart failure' 88,421

#9 'acute heart failure syndrome' 210

#8 'acute heart failure' 15,534

#7 'decompensated heart failure' 4,346

#6 'chronic heart failure' 21,256

#5 'systolic heart failure' 4,610

#4 'heart failure systolic' 119

#3 'diastolic heart failure' 2,680

#2 'heart failure diastolic' 98

#1 'heart failure' 299,896

COCHRANE LIBRARY

#1 Heart Failure 21018

#2 MeSH descriptor: [Heart Failure] explode all trees 6463

#3 Heart Failure, Diastolic 2424

#4 MeSH descriptor: [Heart Failure, Diastolic] explode all trees 30

#5 Heart Failure, Systolic 3808

#6 MeSH descriptor: [Heart Failure, Systolic] explode all trees 137

#7 Chronic heart failure 6695

#8 Decompensated heart failure 587

#9 Acute heart failure 5734

#10 Congestive heart failure 4897

#11 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 21027

#12 MeSH descriptor: [Colombia] explode all trees 135

#13 Colombia 799

#14 MeSH descriptor: [Latin America] explode all trees 105

#15 Latin america 915

#16 Developing countries 5086

#17 #12 or #13 or #14 or #15 or #16 6305

#18 #11 and #17 751

#19 #18 Online Publication Date from Jan 1980 to Jan 2015 492

LILACS

(tw:(falla cardiaca)) OR (tw:(falla cardiaca aguda)) OR (tw:(falla cardiaca crónica)) OR (tw:(falla cardiaca descompensada)) OR (tw:(falla cardiaca diastólica)) OR (tw:(falla cardiaca sistólica)) OR (tw:(insuficiencia cardiaca)) OR (tw:(insuficiencia cardiaca aguda)) OR (tw:(insuficiencia cardiaca congestiva)) OR (tw:(insuficiencia cardiaca crónica)) OR (tw:(insuficiencia cardiaca diastólica)) OR (tw:(insuficiencia cardiaca sistólica)) AND (tw:(Colombia)) OR (tw:(colombiana)) OR (tw:(colombiano)) OR (tw:(america latina)) OR (tw:(latinoamerica))

Combinado con los siguientes años:

AND year_cluster:("2012" OR "2011" OR "2010" OR "2013" OR "2008" OR "2009" OR "2014" OR "2015" OR "2007" OR "2006" OR "2004" OR "2005" OR "2002" OR "2003" OR "1985" OR "1984" OR "1986" OR "2001" OR "1997" OR "2000" OR "1990" OR "1999" OR "1989" OR "1982" OR "1980" OR "1995" OR "1992" OR "1981" OR "1998" OR "1991" OR "1983" OR "1996" OR "1987" OR "1993" OR "1994" OR "1988"))

Received: September 11, 2016; Accepted: February 12, 2017

* Corresponding author: Juan José Diaztagle-Fernández. Internal Medicine Service, Hospital de San José. Carrera.19 No. 8A-32. Telephone number: +57 1 3538100, ext.: 196. Bogotá D.C. Colombia. Email: jjdiaztagle@fucsalud.edu.co.

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