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Revista Colombiana de Estadística

versión impresa ISSN 0120-1751

Rev.Colomb.Estad. vol.42 no.2 Bogotá jul./dic. 2019

http://dx.doi.org/10.15446/rce.v42n2.65344 

Artículos originales de investigación

A Randomized Two Stage Adaptively Censored Design With Application to Testing

Un diseño aleatorio censurado adaptativo en dos etapas con aplicación

Uttam Bandyopadhyaya  , Rahul Bhattacharyab 

aDepartment of Statistics, University of Calcutta, Kolkata, India. E-mail: ubandyopadhyay08@gmail.com

bDepartment of Statistics, University of Calcutta, Kolkata, India. E-mail: rahul_bhattya@yahoo.com

Abstract

A two stage randomized design is developed for two treatment clinical trials in which response variables are exponential and the observations are censored by using failure censoring and time censoring in the first and second stages respectively. The censoring time for the second stage is determined from the outcomes of the first stage. An application to testing for the equality of treatment effects is given along with a comparative study with relevant properties.

Key words: Two stage design; Censoring; Inference

Resumen

Se desarrolla un diseño aleatorizado en dos etapas para dos ensayos clínicos de tratamiento en los que las variables de respuesta son exponenciales y las observaciones se censuran utilizando la censura por fallo y la censura temporal en la primera y segunda etapas, respectivamente. El tiempo de censura para la segunda etapa se determina a partir de los resultados de la primera etapa. Una aplicación para probar la igualdad de efectos del tratamiento se da junto con un estudio comparativo con propiedades relevantes.

Palabras-clave: Diseño de dos etapas; Censura; Inferencia

Full text available only in PDF format.

References

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