Case report

Intraoperative transesophageal echocardiography to evaluate a Gerbode defect^☆

Ecocardiografía transesofágica intraoperatoria para evaluar el defecto tipo Gerbode

Sergio Bustamante^1,*, Shravan Cheruku¹

¹ Anesthesiology Institute, Cleveland Clinic, OH, United States

^☆ Please cite this article as: Bustamante S, Cheruku S. Ecocardiografía transesofágica intraoperatoria para evaluar el defecto tipo Gerbode. Rev Colomb Anestesiol. 2017;45:147-150.
^* Corresponding author at: Cleveland Clinic, 9500 Euclid Avenue J4-331, Cleveland, OH 44195, United States. E-mail address bustams@ccf.org (S. Bustamante).

Article history: Received 24 November 2016 Accepted 15 February 2017

Abstract

The Gerbode Defect is a rare form of intracardiac shunt from the left ventricle to the right atrium resulting from a defect in the membranous portion of the inter-ventricular septum. This defect can be congenital or acquired, with acquired causes including complications of aortic valve replacements and endocarditis. Intraoperative real time transesophageal echocardiography and 3D echocardiography are vital for diagnosis and anatomic characterization of the shunt. A thorough understanding of echocardiography is necessary to visualize the shunt across various anatomic planes which aids in surgical correction.

Keywords: Echocardiography transesophageal, Heart valve diseases, Aortic valve stenosis, Endocarditis, Aortic valve.

Resumen

El Defecto de Gerbode es una rara manifestación de la comunicación interventricular del ventrículo derecho a la aurícula derecha, resultante de un defecto en la porción membranosa del tabique inter-ventricular. El defecto en cuestión puede ser congénito o adquirido y entre las causas adquiridas se encuentran complicaciones de los reemplazos de la válvula aórtica y la endocarditis. La ecocardiografía intraoperatoria en tiempo real y la ecocardiografía en 3D son vitales para el diagnóstico y la caracterización anatómica de la intercomunicación. Se hace necesario comprender a fondo la ecocardiografía para visualizar la intercomunicación a través de distintos planos anatómicos, lo cual ayuda a la corrección quirúrgica.

Palabras clave: Ecocardiografía transesofágica, Enfermedades de las válvulas cardíacas, Estenosis de la válvula aórtica, Endocarditis, Válvula aórtica.

Clinical case

This is a 79-year-old man with history of hyperlipidemia, hypertension and smoking with diffuse 3 vessel coronary artery disease and moderate to severe aortic stenosis who underwent aortic valve replacement (AVR) with a #21 bovine bioprosthetic valve and three vessel coronary artery bypass grafts at an outside hospital (OSH). A year after this procedure the patient presented to an OSH with fluid retention and a new heart murmur. He was found to have prosthetic valve enterococci endocarditis which was subsequently treated with intravenous antibiotics. The patient continued to have complaints of fluid retention and worsening murmur and presented to our hospital for second opinion 8 months later. Physical exam revealed grade 3/6 end systolic murmur and 2/4 long diastolic murmur heard at the left sternal border. Transthoracic echocardiogram showed paravalvular leaks around the bioprosthetic aortic valve with moderate to severe aortic insufficiency (AI), a dilated left ventricle (LV) and additional blood flow originating at the level of the aortic valve communicating with the right atrium (RA). Preoperative CT angiography showed a dilated aortic root with patent bypass grafts.

Due to the severity of the paravalvular leaks and AI, the patient was scheduled for redo AVR. Intraoperative pre-cardiopulmonary bypass transesophageal echocardiography (TEE) confirmed severe AI and dilated LV. Further interrogation confirmed blood flow between the LV and the RA, consistent with an acquired Gerbode-type ventricular septal defect (VSD), with flow present in both systole and diastole. No 2-D or color flow doppler (CFD) evidence of a communication between the aortic root and the RA was seen (Figs. 1-6).

The patient underwent aortic root replacement with a 22 mm homograft and patch repair of the Gerbode defect with PeriGuard® (Synovis, St. Paul, MN, USA). TEE post CPB showed no aortic insufficiency with a peak gradient of 10 mmHg across the Homograft AV. No evidence of Gerbode defect was present. The patient was transferred from the ICU to the regular floor on post-operative day 4 and discharged home on post-op day 8.

Discussion

Our patient presented with stenosis and insufficiency of his bioprosthetic aortic valve with an acquired Gerbode-type VSD. Intraoperative TEE examination was thus tailored to focus on these pathologies before and after surgical repair.

The Gerbode defect is a rare form of shunt from the LV to RA due to either congenital or acquired causes. The defect occurs in the membranous portion of the inter-ventricular septum above the level of the tricuspid valve (Fig. 7). The acquired causes include complications of invasive cardiac procedures like aortic valve replacements, endocarditis, trauma or myocardial infarction. The pathogenesis of an intracardiac fistula with endocarditis is due to translocation of the infection from the valve to adjacent myocardium.^1-3 Real-time TEE is the mainstay for diagnosis and 3-D echocardiography can provide anatomic characterization of the shunt. The TEE views that show the Gerbode defect best are those that can examine the interventricular septum, particularly the membranous septum. These include the mid-esophageal four-chamber view, right ventricular inflow-outflow tract view, trans-gastric short axis and deep trans-gastric views. 3-D echocardiography can help distinguish a Gerbode defect from sinus of Valsalva rupture, ventricular septal defects and tricuspid regurgitation.⁴

Our patient likely developed the Gerbode defect secondary to the surgical intervention he had to replace his aortic valve and/or the enterococci endocarditis. The Gerbode defect was best seen in the mid-esophageal four chamber view, the right ventricular inflow-outflow tract view and deep trans-gastric view (Figs. 1-6). Flow was seen through the defect during both systole and diastole excluding the possibility of tricuspid regurgitation artifact. CFD and 3-D echocardiography were used for anatomic characterization of the defect.

Surgical repair of Gerbode defects had previously been the sole treatment option for patients with symptomatic shunts but over the last two decades percutaneous closure has been increasingly performed.⁴ With percutaneous intervention, 3D TEE has developed into a tool to not only diagnose Gerbode defects but also plays a vital role in percutaneous device sizing and monitoring device deployment. Percutaneous repair was not indicated in our patient as open heart surgery was required to replace the aortic valve. Surgical approach is still the preferred treatment in the repair of a lesion caused by infective endocarditis.⁴ Intraoperative TEE was essential to identify and characterize the defect which helped localize the defect and confirm the repair.

Ethical disclosures

Protection of human and animal subjects. The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association (Declaration of Helsinki).

Confidentiality of data. The authors declare that they have followed the protocols of their work center on the publication of patient data.

Right to privacy and informed consent. The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document

Funding

Institutional Funding provided by the Department of Cardio-thoracic Anesthesiology, Anesthesiology Institute, Cleveland Clinic.

Conflicts of interest

No conflicts of interest to disclose.

Annex. Additional material

Additional material related to the echocardiography videos can be consulted at the electronic version available on http://dx.doi.org/10.1016/j.rcae.2017.03.005.

References

1. Davies A, Lai K, Bastian B. Acquired Gerbode defects associated with infective endocarditis. Heart Lung Circ. 2016;25:e59-61.         [ Links ]

2. Prifti E, Ademaj F, Baboci A, Demiraj A. Acquired Gerbode defect following endocarditis of the tricuspid valve: a case report and literature review. J Cardiothorac Surg. 2015;10:1-7.         [ Links ]

3. Yuan S-M. Acquired left ventricle-to-right atrium shunt: clinical implications and diagnostic dilemmas. Wien Klin Wochenschr. 2015;127:884-92.         [ Links ]

4. Taskesen T, Fred Prouse A, Lewis Goldberg S, Allen Gill E. Gerbode defect: another nail for the 3D transesophagel echo hammer? Int J Cardiovasc Imaging. 2015;31:753-64.         [ Links ]