Letter to the editor. Identification of blood biomarkers: gastric cáncer

Flores-Guerra, Marsyori Anarosa; Lévano-Arias, Leslie Katty; Morón-Valenzuela, Julia Cecilia; Salvador-Carillo, José Fernando; Flores-Guerra, Marsyori Anarosa; Lévano-Arias, Leslie Katty; Morón-Valenzuela, Julia Cecilia; Salvador-Carillo, José Fernando

doi:10.22516/25007440.602

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Revista colombiana de Gastroenterología

Print version ISSN 0120-9957

Rev Col Gastroenterol vol.35 no.3 Bogotá July/Sept. 2020 Epub Mar 01, 2021

https://doi.org/10.22516/25007440.602

Letter to the editor

Letter to the editor. Identification of blood biomarkers: gastric cáncer

Marsyori Anarosa Flores-Guerra¹
http://orcid.org/0000-0003-2935-1376

Leslie Katty Lévano-Arias¹
http://orcid.org/0000-0003-1784-3269

Julia Cecilia Morón-Valenzuela¹
http://orcid.org/0000-0002-1977-3383

José Fernando Salvador-Carillo¹^*
http://orcid.org/0000-0001-7076-6093

^¹Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Filial Chincha, Perú

Keywords: Gastric cancer; Prevention; Genes

Palabras clave: cáncer gástrico; prevención; genes

Dear Editor:

We have read with great interest the article published by Gomez et al.¹, which reports the identification of blood biomarkers that allow detecting different stages of gastric cancer development. It reports that there are 48 genes that allow differentiating patients with chronic gastritis from patients with gastric cancer. Likewise, it describes 14 genes that differentiate diffuse cancer pathologies from intestinal pathologies, as well as a group of 48 genes that distinguish chronic gastritis from intestinal metaplasia in the patients evaluated.

However, we would like to know why the genes that allow distinguishing such pathologies could not be identified. The study states that the extracted RNA was evaluated in the latest whole-genome microarray ². Said technique can identify which genes have altered gene expression in tested patients. Nevertheless, it is not clear why these genes are not mentioned.

This becomes critical in a scenario where publications evaluating biomarkers for gastric cancer in Latin American population are limited. The identification of the genes found could lead to efforts by the scientific community to continue conducting studies to understand the development of gastric cancer in this population. For example, a recent study found that some polymorphisms of interleukins IL-10 and IL-4 could be associated with gastric cancer in Colombian population ³.

That study also presents a significant finding for the detection of pre-malignant lesions and the diagnosis of gastric cancer. However, we cannot give continuity to the results of the work without this valuable information

Acknowledgments

The authors would like to thank the Professional School of Human Medicine of the Universidad Privada San Juan Bautista for providing the necessary support to prepare this letter to the editor

REFERENCES

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3. Cárdenas DM, Sánchez AC, Rosas DA, Rivero E, Paparoni MD, Cruz MA, Suárez YP, Galvis NF. Preliminary analysis of single-nucleotide polymorphisms in IL-10, IL-4, and IL-4Rα genes and profile of circulating cytokines in patients with gastric Cancer. BMC Gastroenterol. 2018;18(1):184. http://doi.org/10.1186/s12876-018-0913-9 [ Links ]

Citation: Flores-Guerra MA, Lévano-Arias LK, Morón-Valenzuela JC, Salvador-Carillo JF. Letter to the editor. Identification of blood biomarkers: gastric cancer. Rev Colomb Gastroenterol. 2020;35(3):394-395. https://doi.org/10.22516/25007440.602

Received: June 26, 2020; Accepted: July 30, 2020

^*Correspondence: José Fernando Salvador-Carillo jose.salvador@upsjb.edu.pe

^{Conflict of interest}

None declared by the authors.

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