<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182018000100037</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v47n1.70657</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Caracterização química e citotoxicidade do óleo essencial do cravo-da-índia (Syzygium aromaticum)]]></article-title>
<article-title xml:lang="en"><![CDATA[Chemical characterization and cytotoxicity of clove essential oil (Syzygium aromaticum)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barros Gomes]]></surname>
<given-names><![CDATA[Paulo Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mouchrek Filho]]></surname>
<given-names><![CDATA[Victor Elias]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira Rabêlo]]></surname>
<given-names><![CDATA[Waléria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Albuquerque do Nascimento]]></surname>
<given-names><![CDATA[Alexandre]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Costa Louzeiro]]></surname>
<given-names><![CDATA[Hilton]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[da Silva Lyra]]></surname>
<given-names><![CDATA[Wellington]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fontenele]]></surname>
<given-names><![CDATA[Maria Alves]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal do Maranhão  ]]></institution>
<addr-line><![CDATA[São Luís Maranhão]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal da Paraíba  ]]></institution>
<addr-line><![CDATA[João Pessoa Paraíba]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal do Maranhão  ]]></institution>
<addr-line><![CDATA[Imperatriz Maranhão]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2018</year>
</pub-date>
<volume>47</volume>
<numero>1</numero>
<fpage>37</fpage>
<lpage>52</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182018000100037&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182018000100037&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182018000100037&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO Este trabalho avalia as propriedades-físico químicas do óleo essencial dos botões florais seco do cravo-da-índia (Syzygium aromaticum) que são encontradas no Municipio de São Luís, Maranhão. Extraiu-se quantitativamente o óleo essencial por hidrodestilação. Determinaram-se as propriedades físico-químicas do óleo essencial (densidade, índice de refração, solubilidade, cor e aparência) e atividade citotóxica frente às larvas da Artemia salina. Caracterizou-se analiticamente o óleo por cromatografia gasosa acoplada a espectrómetro de massas (CG-EM). Os resul tados mostram que o melhor tempo e o rendimento do óleo foram correspondente mente 4 horas e 4,33 % de massa por volume. A partir disso foi possível identificar 5 componentes, sendo a presença majoritária do eugenol que logo foi confirmada pelas técnicas espectroscópica. Na identificação do componente majoritário e dos demais componentes, bem como suas quantificações, as técnicas foram precisas e os métodos eficientes, proporcionando um bom desempenho analítico nas determinações.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Summary This work evaluates the physical-chemical properties of the essential oil of the dry floral buds of clove (Syzygium aromaticum) that are found in the Municipality of Saint Louis, Maranhão. The essential oil was quantitatively extracted by hydrodistil lation. The physicochemical properties of the essential oil (density, refractive index, solubility, color and appearance) and cytotoxic activity against larvae of Artemia salina were determined. The oil was analytically characterized by gas chromatog raphy coupled to mass spectrometer (GC-MS). The results show that the best time and yield of the oil were correspondingly 4 hours and 4.33% mass per volume. From this, it was possible to identify five components, being the major presence of eugenol that soon was confirmed by the spectroscopic techniques. In the identification of the major component and the other components, as well as their quantifications, the techniques were precise and the methods efficient, providing a good analytical performance in the determinations.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[avaliação físico-química]]></kwd>
<kwd lng="pt"><![CDATA[Syzygium aromaticum]]></kwd>
<kwd lng="pt"><![CDATA[botões florais]]></kwd>
<kwd lng="pt"><![CDATA[Eugenol]]></kwd>
<kwd lng="pt"><![CDATA[hidrodestilação]]></kwd>
<kwd lng="en"><![CDATA[Physical-chemical evaluation]]></kwd>
<kwd lng="en"><![CDATA[Syzygium aromaticum]]></kwd>
<kwd lng="en"><![CDATA[floral buds]]></kwd>
<kwd lng="en"><![CDATA[Eugenol]]></kwd>
<kwd lng="en"><![CDATA[hydrodistillation]]></kwd>
</kwd-group>
</article-meta>
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