<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182019000100005</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v48n1.80062</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Dos distúrbios psiquiátricos à antibioticoterapia: reposicionamento da clorpromazina como agente antibacteriano]]></article-title>
<article-title xml:lang="en"><![CDATA[From psychiatric disorders to antibiotic therapy: repositioning of chlorpromazine as an antibacterial agent]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[William Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos-Alves]]></surname>
<given-names><![CDATA[Maria Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[Adriana Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal de São João del Rei  ]]></institution>
<addr-line><![CDATA[Divinópolis Minas Gerais]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal de São João del-Rei  ]]></institution>
<addr-line><![CDATA[Divinópolis Minas Gerais]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal de São João del Rei  ]]></institution>
<addr-line><![CDATA[Divinópolis Minas Gerais]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>48</volume>
<numero>1</numero>
<fpage>5</fpage>
<lpage>28</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182019000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182019000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182019000100005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO O alarmante aumento na taxa de resistência aos antibióticos põe em check à eficácia da terapia antibacteriana futura. Em contrapartida, as indústrias farmacêuticas negligenciam os investimentos em pesquisa e desenvolvimento de novos fármacos antimicrobianos em virtude de questões financeiras, legais e farmacológicas. Assim sendo, o reposicionamento de agentes disponíveis clinicamente torna-se uma promissora ferramenta para tentar driblar o desinteresse das indústrias. O fármaco antipsicótico clorpromazina (CPZ) destaca-se por possuir uma ampla faixa de atividade antibacteriana, a qual cobre desde patógenos Gram-positivos e Gram-negativos, até as mico-bactérias. A atividade antibacteriana é independente do perfil de susceptibilidade do microrganismo, sendo ela mantida mesmo em cepas altamente resistentes aos antibióticos. Alguns estudos mostram que mesmo nas concentrações clinicamente disponíveis no plasma (entre 0,1-0,5 (g/mL), a CPZ é capaz de matar Staphylococcus aureus e Mycobacterium tuberculosis dentro dos macrófagos. Em adição, estudos clínicos têm revelado os benefícios do uso da CPZ na terapia de suporte para pacientes com infecções em curso. Em conclusão, a CPZ pode eventualmente ser direcionada ao arsenal terapêutico antimicrobiano, especialmente no manejo das infecções causadas por microrganismos intracelulares com fenótipo multirresistente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY The substantial increase in the antibiotic resistance brings on an alarm to the future of the antibiotic therapy. However, the pharmaceutical industry has been neglecting its investments in new drug research and development, mainly because of the pharmacologic, financial and legal factors. Therefore, the drug repositioning of clinic available agents become a promising tool to bypass the lack of interest of the pharmaceutical industry. A drug used to treat psychoses, the Chlorpromazine (CPZ), stands out as a large spectrum antibiotic, which covers Gram-positive and Gram -negative bacteria, and also mycobacteria. Its antibacterial activity is not related to microorganism susceptibility profile, and it could be maintained even on strains highly resistant to the conventional antibiotics. Studies point out that even on serum concentrations clinically available, the CPZ can eliminate Staphylococcus aureus and Mycobacterium tuberculosis inside of macrophages. In addition, clinical trials have revealed its benefits on support therapy for patients suffering from active infections. As a result, the CPZ could be used as an optional antibiotic therapy, especially in case of infections due to intracellular microorganisms with multidrug resistance phenotype.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Reposicionamento de fármacos]]></kwd>
<kwd lng="pt"><![CDATA[fenotiazina]]></kwd>
<kwd lng="pt"><![CDATA[bombas de efluxo]]></kwd>
<kwd lng="pt"><![CDATA[resistência bacteriana]]></kwd>
<kwd lng="pt"><![CDATA[Staphylococccus aureus]]></kwd>
<kwd lng="pt"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Drug repositioning]]></kwd>
<kwd lng="en"><![CDATA[phenothiazine]]></kwd>
<kwd lng="en"><![CDATA[efflux pumps]]></kwd>
<kwd lng="en"><![CDATA[bacterial resistance]]></kwd>
<kwd lng="en"><![CDATA[Staphylococccus aureus]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium tuberculosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spellberg]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Powers]]></surname>
<given-names><![CDATA[J.H]]></given-names>
</name>
<name>
<surname><![CDATA[Brass]]></surname>
<given-names><![CDATA[E.P]]></given-names>
</name>
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[L.G]]></given-names>
</name>
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Trends in Antimicrobial Drug Development: Implications for the Future]]></article-title>
<source><![CDATA[Clin. Infect. Dis]]></source>
<year>2004</year>
<volume>38</volume>
<page-range>1279</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="">
<collab>World Health Organization (WHO)</collab>
<source><![CDATA[The top 10 causes of death: The 10 leading causes of death by country income group]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="">
<collab>World Health Organization (WHO)</collab>
<source><![CDATA[Antimicrobial resistance: Global report on surveillance]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[O'Neill]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tackling drug-resistant infections globally: final report and recommendations]]></article-title>
<source><![CDATA[Review on Antimicrobial Resistance]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barros]]></surname>
<given-names><![CDATA[L.M]]></given-names>
</name>
<name>
<surname><![CDATA[Castro]]></surname>
<given-names><![CDATA[J.N.B]]></given-names>
</name>
<name>
<surname><![CDATA[Caetano]]></surname>
<given-names><![CDATA[J.A]]></given-names>
</name>
<name>
<surname><![CDATA[Moreira]]></surname>
<given-names><![CDATA[R.A.N]]></given-names>
</name>
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[F.G.F]]></given-names>
</name>
<name>
<surname><![CDATA[Frota]]></surname>
<given-names><![CDATA[N.M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalência de micro-organismo e sensibilidade antimicrobiana de infecções hospitalares em unidade de terapia intensiva de hospital público no Brasil]]></article-title>
<source><![CDATA[Rev. Ciênc. Farm. Básica Apl]]></source>
<year>2012</year>
<volume>33</volume>
<numero>429</numero>
<issue>429</issue>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanchez-Velazquez]]></surname>
<given-names><![CDATA[L.D]]></given-names>
</name>
<name>
<surname><![CDATA[Rosales]]></surname>
<given-names><![CDATA[S.P.L]]></given-names>
</name>
<name>
<surname><![CDATA[Fausto]]></surname>
<given-names><![CDATA[M.S.R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The burden of nosocomial infection in the intensive care unit: effects on organ failure, mortality and costs. A Nested case-control study]]></article-title>
<source><![CDATA[Arch. Med. Res]]></source>
<year>2006</year>
<volume>37</volume>
<numero>370</numero>
<issue>370</issue>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Talbolt]]></surname>
<given-names><![CDATA[G.H]]></given-names>
</name>
<name>
<surname><![CDATA[Bradley]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
<name>
<surname><![CDATA[Gilbert]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Scheld]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bartlett]]></surname>
<given-names><![CDATA[J.G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bad bugs need drugs: An update on the development pipeline from the antimicrobial availability task force of the infectious diseases society of America]]></article-title>
<source><![CDATA[Clin. Infect. Dis]]></source>
<year>2006</year>
<volume>42</volume>
<numero>657</numero>
<issue>657</issue>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boucher]]></surname>
<given-names><![CDATA[H.W]]></given-names>
</name>
<name>
<surname><![CDATA[Talbot]]></surname>
<given-names><![CDATA[G.H]]></given-names>
</name>
<name>
<surname><![CDATA[Bradley]]></surname>
<given-names><![CDATA[J.S]]></given-names>
</name>
<name>
<surname><![CDATA[Edwards]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
<name>
<surname><![CDATA[D]]></surname>
<given-names><![CDATA[D. Gilbert]]></given-names>
</name>
<name>
<surname><![CDATA[Rice]]></surname>
<given-names><![CDATA[L.B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bad bugs, no drugs: no ESKAPE! An update from the infectious diseases society of America]]></article-title>
<source><![CDATA[Clin. Infect. Dis]]></source>
<year>2009</year>
<volume>48</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Theuretzbacher]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Future antibiotics scenarios: is the tide starting to turn?]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2009</year>
<volume>34</volume>
<numero>15</numero>
<issue>15</issue>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dimasi]]></surname>
<given-names><![CDATA[J.A]]></given-names>
</name>
<name>
<surname><![CDATA[Hansen]]></surname>
<given-names><![CDATA[R.W]]></given-names>
</name>
<name>
<surname><![CDATA[Grabowski]]></surname>
<given-names><![CDATA[H.G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The price of innovation: new estimates of drug development costs]]></article-title>
<source><![CDATA[J. Health. Econ]]></source>
<year>2003</year>
<volume>22</volume>
<numero>151</numero>
<issue>151</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The potential management of resistant infections with non-antibiotics]]></article-title>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>1997</year>
<volume>40</volume>
<numero>319</numero>
<issue>319</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahmed]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Shaw]]></surname>
<given-names><![CDATA[H.V]]></given-names>
</name>
<name>
<surname><![CDATA[Koval]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Katanaev]]></surname>
<given-names><![CDATA[V.L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A second WNT for old drugs: drug repositioning against WNT-dependent cancers]]></article-title>
<source><![CDATA[Cancers (Basel)]]></source>
<year>2016</year>
<volume>8</volume>
<numero>E66</numero>
<issue>E66</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Molnar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial activity of phenothiazines]]></article-title>
<source><![CDATA[In Vivo]]></source>
<year>2004</year>
<volume>18</volume>
<numero>725</numero>
<issue>725</issue>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Crowle]]></surname>
<given-names><![CDATA[J.A]]></given-names>
</name>
<name>
<surname><![CDATA[Douvas]]></surname>
<given-names><![CDATA[G.S]]></given-names>
</name>
<name>
<surname><![CDATA[May]]></surname>
<given-names><![CDATA[M.H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorpromazine: a drug potentially useful for treating mycobacterial infections]]></article-title>
<source><![CDATA[Chemotherapy]]></source>
<year>1992</year>
<volume>38</volume>
<numero>410</numero>
<issue>410</issue>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[M.M]]></given-names>
</name>
<name>
<surname><![CDATA[Leandro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ordway]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2003</year>
<volume>22</volume>
<numero>250</numero>
<issue>250</issue>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[M.M]]></given-names>
</name>
<name>
<surname><![CDATA[Leandro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ordway]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pacheco]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thioridazine reduces resistance of methicillin-resistant Staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump]]></article-title>
<source><![CDATA[In Vivo]]></source>
<year>2006</year>
<volume>20</volume>
<numero>361</numero>
<issue>361</issue>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molnár]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Hevér]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fakla]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Fischer]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Ocsovski]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Aszalós]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of the transport function of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells]]></article-title>
<source><![CDATA[Anticancer Res]]></source>
<year>1997</year>
<volume>17</volume>
<numero>481</numero>
<issue>481</issue>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kaatz]]></surname>
<given-names><![CDATA[G.W]]></given-names>
</name>
<name>
<surname><![CDATA[Moudgal]]></surname>
<given-names><![CDATA[V.V]]></given-names>
</name>
<name>
<surname><![CDATA[Seo]]></surname>
<given-names><![CDATA[S.M]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus, Antimicrob]]></article-title>
<source><![CDATA[Agents Chemother]]></source>
<year>2003</year>
<volume>47</volume>
<numero>719</numero>
<issue>719</issue>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The antimicrobial activity of psychotherapeutic drugs and stereo-isomeric analogues]]></article-title>
<source><![CDATA[Dan. Med. Bull]]></source>
<year>1990</year>
<volume>37</volume>
<numero>165</numero>
<issue>165</issue>
</nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lorian]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Synergic effect of chlorpromazine on the activity of some antibiotics]]></article-title>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>1992</year>
<volume>30</volume>
<numero>556</numero>
<issue>556</issue>
</nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baugh]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ekanayaka]]></surname>
<given-names><![CDATA[A.S]]></given-names>
</name>
<name>
<surname><![CDATA[Piddock]]></surname>
<given-names><![CDATA[L.J]]></given-names>
</name>
<name>
<surname><![CDATA[Webber]]></surname>
<given-names><![CDATA[M.A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm]]></article-title>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>2012</year>
<volume>67</volume>
<numero>2409</numero>
<issue>2409</issue>
</nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Charpentier]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Gailliot]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Jacob]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gaudechon]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Buisson]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recherches sur les diméthylaminopropyl-N phénothiazines substituées]]></article-title>
<source><![CDATA[Comptes rendus de l'Académie des sciences]]></source>
<year>1952</year>
<volume>235</volume>
<numero>59</numero>
<issue>59</issue>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[WW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A history of antipsychotic drug development]]></article-title>
<source><![CDATA[Compr. Psychiatry]]></source>
<year>1999</year>
<volume>40</volume>
<numero>407</numero>
<issue>407</issue>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lickey]]></surname>
<given-names><![CDATA[M.E]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Medicamentos para las enfermedades mentales]]></article-title>
<source><![CDATA[Labor: Barcelona]]></source>
<year>1986</year>
<volume>78</volume>
</nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="">
<collab>World Health Organization (WHO)</collab>
<source><![CDATA[WHO model list of essential medicines]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katzung]]></surname>
<given-names><![CDATA[B.G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Farmacologia: básica e clínica]]></article-title>
<source><![CDATA[Guanabara Koogan]]></source>
<year>2005</year>
<volume>9</volume>
<page-range>1216</page-range><publisher-loc><![CDATA[Rio de Janeiro ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Graeff]]></surname>
<given-names><![CDATA[F.G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antipsicóticos]]></article-title>
<source><![CDATA[Drogas psicotrópicas e seu modo de ação]]></source>
<year>1989</year>
<volume>1</volume>
<page-range>110</page-range><publisher-loc><![CDATA[São Paulo ]]></publisher-loc>
<publisher-name><![CDATA[E.P.U]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Graeff]]></surname>
<given-names><![CDATA[F.G]]></given-names>
</name>
<name>
<surname><![CDATA[Guimarães]]></surname>
<given-names><![CDATA[F.S]]></given-names>
</name>
</person-group>
<source><![CDATA[Fundamentos de psicofarmacologia]]></source>
<year>1999</year>
<volume>2</volume>
<page-range>288</page-range><publisher-loc><![CDATA[São Paulo ]]></publisher-loc>
<publisher-name><![CDATA[Atheneu Eds]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[R.C.B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Esquizofrenia: uma revisão]]></article-title>
<source><![CDATA[Psicologia USP]]></source>
<year>2006</year>
<volume>17</volume>
<numero>263</numero>
<issue>263</issue>
</nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gillman]]></surname>
<given-names><![CDATA[P.K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serotonin syndrome: history and risk]]></article-title>
<source><![CDATA[Fundam. Clin. Pharmacol]]></source>
<year>1998</year>
<volume>12</volume>
<numero>482</numero>
<issue>482</issue>
</nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gillman]]></surname>
<given-names><![CDATA[P.K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The serotonin syndrome and its treatment]]></article-title>
<source><![CDATA[J. Psychopharmacol]]></source>
<year>1999</year>
<volume>13</volume>
<numero>100</numero>
<issue>100</issue>
</nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wildin]]></surname>
<given-names><![CDATA[J.D]]></given-names>
</name>
<name>
<surname><![CDATA[Pleuvry]]></surname>
<given-names><![CDATA[B.J]]></given-names>
</name>
<name>
<surname><![CDATA[Mawer]]></surname>
<given-names><![CDATA[G.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impairment of psychomotor function at modest plasmaconcentrations of carbamazepine after administration of liquid suspension to naive subjects]]></article-title>
<source><![CDATA[Br. J. Clin. Pharmacol]]></source>
<year>1993</year>
<volume>35</volume>
<numero>14</numero>
<issue>14</issue>
</nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wik]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of neuroleptic treatment on cortisol and 3-methoxy-4-hydro-xyphenylethyl glycol levels in blood]]></article-title>
<source><![CDATA[J. Endocrinol]]></source>
<year>1995</year>
<volume>144</volume>
<numero>425</numero>
<issue>425</issue>
</nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lipka]]></surname>
<given-names><![CDATA[L.J]]></given-names>
</name>
<name>
<surname><![CDATA[Lathers]]></surname>
<given-names><![CDATA[C.M]]></given-names>
</name>
<name>
<surname><![CDATA[Roberts]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Does chlorpromazine produce cardiac arrhythmia via the central nervous system?]]></article-title>
<source><![CDATA[J. Clin. Pharmacol]]></source>
<year>1988</year>
<volume>28</volume>
<numero>968</numero>
<issue>968</issue>
</nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[S.Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[Y.H]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[Y.K]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[K.T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorpromazine inhibits store-operated calcium entry and subsequent noradrenaline secretion in PC12 cells]]></article-title>
<source><![CDATA[Br. J. Pharmacol]]></source>
<year>2001</year>
<volume>132</volume>
<numero>411</numero>
<issue>411</issue>
</nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ghosh]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Chattopadhyay]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enhancement of immune response by phenothia-zine administration]]></article-title>
<source><![CDATA[In Vivo, In Vivo]]></source>
<year>1993</year>
<volume>7</volume>
<numero>435</numero>
<issue>435</issue>
</nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lialiaris]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Pantazaki]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Sivridis]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Mourelatos]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorpromazine-induced damage on nucleic acids: acombined cytogenetic and biochemical study]]></article-title>
<source><![CDATA[Mutat. Res]]></source>
<year>1992</year>
<volume>265</volume>
<numero>155</numero>
<issue>155</issue>
</nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Machado]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Cerca]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Spengler]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Role of calcium in the efflux system of Escherichia coli]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2011</year>
<volume>37</volume>
<numero>410</numero>
<issue>410</issue>
</nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menezes]]></surname>
<given-names><![CDATA[C.M]]></given-names>
</name>
<name>
<surname><![CDATA[Kirchgatter]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Di Santi]]></surname>
<given-names><![CDATA[S.M]]></given-names>
</name>
<name>
<surname><![CDATA[Savalli]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Monteiro]]></surname>
<given-names><![CDATA[F.G]]></given-names>
</name>
<name>
<surname><![CDATA[Paula]]></surname>
<given-names><![CDATA[G.A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phe-nothiazine drugs]]></article-title>
<source><![CDATA[Mem. Inst. Oswaldo Cruz]]></source>
<year>2002</year>
<volume>97</volume>
<numero>1033</numero>
<issue>1033</issue>
</nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kyle]]></surname>
<given-names><![CDATA[D.E]]></given-names>
</name>
<name>
<surname><![CDATA[Gerena]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Milhous]]></surname>
<given-names><![CDATA[W.K]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[A.J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design, synthesis and evaluation of new chemosensitizers in multi-drug-resistant Plasmo-dium falciparum]]></article-title>
<source><![CDATA[J. Med. Chem]]></source>
<year>2002</year>
<volume>45</volume>
<numero>2741</numero>
<issue>2741</issue>
</nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kalkanidis]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Klonis]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Tilley]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Deady]]></surname>
<given-names><![CDATA[L.W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Novel phenothiazine antimala-rials: synthesis, antimalarial activity, and inhibition of the formation of beta-haematin]]></article-title>
<source><![CDATA[Biochem. Pharmacol]]></source>
<year>2002</year>
<volume>63</volume>
<numero>833</numero>
<issue>833</issue>
</nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pearson]]></surname>
<given-names><![CDATA[R.D]]></given-names>
</name>
<name>
<surname><![CDATA[Manian]]></surname>
<given-names><![CDATA[A.A]]></given-names>
</name>
<name>
<surname><![CDATA[Hall]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Harcus]]></surname>
<given-names><![CDATA[J.L]]></given-names>
</name>
<name>
<surname><![CDATA[Hewlett]]></surname>
<given-names><![CDATA[E.L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antileishmanial activity of chlorpromazine, Antimicrob]]></article-title>
<source><![CDATA[Agents Chemother]]></source>
<year>1984</year>
<volume>25</volume>
<numero>571</numero>
<issue>571</issue>
</nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berman]]></surname>
<given-names><![CDATA[J.D]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[L.S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Activity of oral drugs against Leishmania tropica in human macrophages in vitro]]></article-title>
<source><![CDATA[Am. J. Trop. Med. Hyg]]></source>
<year>1983</year>
<volume>32</volume>
<numero>947</numero>
<issue>947</issue>
</nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Galgóczy]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bácsi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Homa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Virágh]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Papp]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vágvölgyi, In vitro anti-fungal activity of phenothiazines and their combination with amphotericin B against different Candida species]]></article-title>
<source><![CDATA[Mycoses]]></source>
<year>2011</year>
<volume>54</volume>
<numero>737</numero>
<issue>737</issue>
</nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vitale]]></surname>
<given-names><![CDATA[R.G]]></given-names>
</name>
<name>
<surname><![CDATA[Afeltra]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Meis]]></surname>
<given-names><![CDATA[J.F]]></given-names>
</name>
<name>
<surname><![CDATA[Verweij]]></surname>
<given-names><![CDATA[P.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Activity and post antifungal effect of chlorpromazine and trifluopherazine against Aspergillus, Scedosporium and zygomycetes]]></article-title>
<source><![CDATA[Mycoses]]></source>
<year>2007</year>
<volume>50</volume>
<numero>270</numero>
<issue>270</issue>
</nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J.H]]></given-names>
</name>
<name>
<surname><![CDATA[Jung]]></surname>
<given-names><![CDATA[S.Y]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[Y.J]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[K.J]]></given-names>
</name>
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of therapeutic chemical agents in vitro and on experimental meningoencephalitis due to Naegleria fowleri, Antimicrob]]></article-title>
<source><![CDATA[Agents Chemother]]></source>
<year>2008</year>
<volume>52</volume>
<numero>4010</numero>
<issue>4010</issue>
</nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shimizu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Modification of host cell membrane after herpes simplex virus infection]]></article-title>
<source><![CDATA[Arch. Gesamte. Virusforsch]]></source>
<year>1971</year>
<volume>33</volume>
<numero>338</numero>
<issue>338</issue>
</nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Libikowa]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Stancek]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Wiedermann]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Hasto]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Breier]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Psychopharmacy and electroconvulsive therapy in relation to viral antibodies and interferon. Experimental and clinical study]]></article-title>
<source><![CDATA[Arch. Immunol. Ther. Exp. Warsz]]></source>
<year>1977</year>
<volume>25</volume>
<numero>641</numero>
<issue>641</issue>
</nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hirschman]]></surname>
<given-names><![CDATA[S.Z]]></given-names>
</name>
<name>
<surname><![CDATA[Garfinkel]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of hepatitis B DNA polymerase by intercalating agents]]></article-title>
<source><![CDATA[Nature]]></source>
<year>1978</year>
<volume>271</volume>
<numero>681</numero>
<issue>681</issue>
</nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bohn]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Rutter]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hohenberg]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Mannweiler]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of measles virus budding by phenothiazines]]></article-title>
<source><![CDATA[Virology]]></source>
<year>1983</year>
<volume>15</volume>
<numero>44</numero>
<issue>44</issue>
</nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schlesinge]]></surname>
<given-names><![CDATA[M.J]]></given-names>
</name>
<name>
<surname><![CDATA[Cahill]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Verapamil and chlorpromazine inhibit the budding of Sindbis and vesicular stomatitis viruses from infected chicken embryo fibro-blasts]]></article-title>
<source><![CDATA[Virology]]></source>
<year>1989</year>
<volume>168</volume>
<numero>187</numero>
<issue>187</issue>
</nlm-citation>
</ref>
<ref id="B52">
<label>52</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nugent]]></surname>
<given-names><![CDATA[K.M]]></given-names>
</name>
<name>
<surname><![CDATA[Shanley]]></surname>
<given-names><![CDATA[J.D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Verapamil inhibits influenza A virus replication]]></article-title>
<source><![CDATA[Arch. Virol]]></source>
<year>1984</year>
<volume>81</volume>
<numero>163</numero>
<issue>163</issue>
</nlm-citation>
</ref>
<ref id="B53">
<label>53</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hirai]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Takeda]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Natori]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sekimizu]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of SV40 DNA replication in vitro by chlorpromazine]]></article-title>
<source><![CDATA[Biol. Pharm. Bull]]></source>
<year>1993</year>
<volume>16</volume>
<numero>565</numero>
<issue>565</issue>
</nlm-citation>
</ref>
<ref id="B54">
<label>54</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Candurra]]></surname>
<given-names><![CDATA[N.A]]></given-names>
</name>
<name>
<surname><![CDATA[Maskin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Damonte]]></surname>
<given-names><![CDATA[E.B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of arenavirus multiplication in vitro by phenotiazines]]></article-title>
<source><![CDATA[Antiviral Res]]></source>
<year>1996</year>
<volume>31</volume>
<numero>149</numero>
<issue>149</issue>
</nlm-citation>
</ref>
<ref id="B55">
<label>55</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Atwood]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus ( JCV) in a tissue culture model: implications for prophylactic and therapeutic treatment of progressive multifocal leukoencephalopathy]]></article-title>
<source><![CDATA[J. Neurovirol]]></source>
<year>2001</year>
<volume>7</volume>
<numero>307</numero>
<issue>307</issue>
</nlm-citation>
</ref>
<ref id="B56">
<label>56</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Experiments to illustrate the effect of chlorpromazine on the permeability of the bacterial cell wall]]></article-title>
<source><![CDATA[Acta Pathol. Microbiol. Scand. B]]></source>
<year>1979</year>
<volume>87</volume>
<numero>317</numero>
<issue>317</issue>
</nlm-citation>
</ref>
<ref id="B57">
<label>57</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ordway]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Leandro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Jorge Arroz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Molnar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorpromazine has intracellular killing activity against phagocytosed Sta-phylococcus aureus at clinical concentrations]]></article-title>
<source><![CDATA[J. Infect. Chemother]]></source>
<year>2002</year>
<volume>8</volume>
<numero>227</numero>
<issue>227</issue>
</nlm-citation>
</ref>
<ref id="B58">
<label>58</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nehme]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Saulnier]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ramadan]]></surname>
<given-names><![CDATA[A. A]]></given-names>
</name>
<name>
<surname><![CDATA[Cassisa]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Guillet]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Eveillard]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Umerska]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial activity of antipsychotic agents, their association with lipid nanocapsules and its impact on the properties of the nanocarriers and on antibacterial activity]]></article-title>
<source><![CDATA[PLoS One]]></source>
<year>2018</year>
<volume>13</volume>
<numero>e0189950</numero>
<issue>e0189950</issue>
</nlm-citation>
</ref>
<ref id="B59">
<label>59</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kong]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[O.H]]></given-names>
</name>
<name>
<surname><![CDATA[Seo]]></surname>
<given-names><![CDATA[Y.S]]></given-names>
</name>
<name>
<surname><![CDATA[Mun]]></surname>
<given-names><![CDATA[S.H]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Shin]]></surname>
<given-names><![CDATA[D.W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The inhibition effect of Chlorpromazine against the b-lactam resistance of MRSA]]></article-title>
<source><![CDATA[Asian Pacific J. Trop. Med]]></source>
<year>2016</year>
<volume>9</volume>
<numero>542</numero>
<issue>542</issue>
</nlm-citation>
</ref>
<ref id="B60">
<label>60</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rahbar]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mehrgan]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Hadji-Nejad]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro]]></article-title>
<source><![CDATA[Basic Clin. Pharmacol. Toxicol]]></source>
<year>2010</year>
<volume>107</volume>
<numero>676</numero>
<issue>676</issue>
</nlm-citation>
</ref>
<ref id="B61">
<label>61</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hendricks]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Butterworth]]></surname>
<given-names><![CDATA[T.S]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The in-vitro antimicrobial effect of non-antibiotics and putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2003</year>
<volume>22</volume>
<numero>262</numero>
<issue>262</issue>
</nlm-citation>
</ref>
<ref id="B62">
<label>62</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dudley]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[De Haan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chlorpromazine dose for people with schizophrenia]]></article-title>
<source><![CDATA[Cochrane Database Syst. Rev]]></source>
<year>2017</year>
<volume>13</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B63">
<label>63</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Atouguia]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as anti-tuberculosis therapy]]></article-title>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>2000</year>
<volume>47</volume>
<numero>505</numero>
<issue>505</issue>
</nlm-citation>
</ref>
<ref id="B64">
<label>64</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phenothiazines: potential management of Creutz-feldt-Jakob disease and its variants]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2001</year>
<volume>18</volume>
<numero>411</numero>
<issue>411</issue>
</nlm-citation>
</ref>
<ref id="B65">
<label>65</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molnár]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Mándi]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Király]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial effect of some phenothiazine compounds and R-factor elimination by chlorpromazine]]></article-title>
<source><![CDATA[Acta Microbiol. Acad. Sci. Hung]]></source>
<year>1976</year>
<volume>23</volume>
<numero>45</numero>
<issue>45</issue>
</nlm-citation>
</ref>
<ref id="B66">
<label>66</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
<name>
<surname><![CDATA[Mortensen]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial effect of four phenothiazines]]></article-title>
<source><![CDATA[Pharmacol. Toxicol]]></source>
<year>1987</year>
<volume>60</volume>
<numero>100</numero>
<issue>100</issue>
</nlm-citation>
</ref>
<ref id="B67">
<label>67</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Lorian]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Synergic effect of chlorpromazine on the activity of some antibiotics]]></article-title>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>1992</year>
<volume>30</volume>
<numero>556</numero>
<issue>556</issue>
</nlm-citation>
</ref>
<ref id="B68">
<label>68</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coutinho]]></surname>
<given-names><![CDATA[H.D]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[J.G]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[E.O]]></given-names>
</name>
<name>
<surname><![CDATA[Falcão-Silva]]></surname>
<given-names><![CDATA[V.S]]></given-names>
</name>
<name>
<surname><![CDATA[Siqueira-Júnior]]></surname>
<given-names><![CDATA[J.P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enhancement of the antibiotic activity against a multiresistant Escherichia coli by Mentha arvensis L. and chlorpromazine]]></article-title>
<source><![CDATA[Chemotherapy]]></source>
<year>2008</year>
<volume>54</volume>
<numero>328</numero>
<issue>328</issue>
</nlm-citation>
</ref>
<ref id="B69">
<label>69</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coutinho]]></surname>
<given-names><![CDATA[H.D]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[J.G]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[E.O]]></given-names>
</name>
<name>
<surname><![CDATA[Falcão-Silva]]></surname>
<given-names><![CDATA[V.S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro interference of Hyptis martiusii Benth. &amp; chlorpromazine against an ami-noglycoside-resistant Escherichia coli, Indian]]></article-title>
<source><![CDATA[J. Med. Res]]></source>
<year>2009</year>
<volume>129</volume>
<numero>566</numero>
<issue>566</issue>
</nlm-citation>
</ref>
<ref id="B70">
<label>70</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coutinho]]></surname>
<given-names><![CDATA[H.D]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[J.G]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[E.O]]></given-names>
</name>
<name>
<surname><![CDATA[Falcão-Silva]]></surname>
<given-names><![CDATA[V.S]]></given-names>
</name>
<name>
<surname><![CDATA[Siqueira-Júnior]]></surname>
<given-names><![CDATA[J.P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increasing of the aminoglicosyde antibiotic activity against a multidrug-resistant E. coli by Turnera ulmifolia L. and chlorpromazine]]></article-title>
<source><![CDATA[Biol. Res. Nurs]]></source>
<year>2010</year>
<volume>11</volume>
<numero>332</numero>
<issue>332</issue>
</nlm-citation>
</ref>
<ref id="B71">
<label>71</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bailey]]></surname>
<given-names><![CDATA[A.M]]></given-names>
</name>
<name>
<surname><![CDATA[Paulsen]]></surname>
<given-names><![CDATA[I.T]]></given-names>
</name>
<name>
<surname><![CDATA[Piddock]]></surname>
<given-names><![CDATA[L.J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlor-promazine, Antimicrob]]></article-title>
<source><![CDATA[Agents Chemother]]></source>
<year>2008</year>
<volume>52</volume>
<numero>3604</numero>
<issue>3604</issue>
</nlm-citation>
</ref>
<ref id="B72">
<label>72</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
<name>
<surname><![CDATA[Blom]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of chlorpromazine on the ultrastructure of Staphylococcus aureus]]></article-title>
<source><![CDATA[Acta Pathol. Microbiol. Scand B]]></source>
<year>1981</year>
<volume>89</volume>
<numero>399</numero>
<issue>399</issue>
</nlm-citation>
</ref>
<ref id="B73">
<label>73</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Lorian]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of chlorpromazine on the cell envelope proteins of Escherichia coli, Antimicrob]]></article-title>
<source><![CDATA[Agents Chemother]]></source>
<year>1991</year>
<volume>35</volume>
<numero>1923</numero>
<issue>1923</issue>
</nlm-citation>
</ref>
<ref id="B74">
<label>74</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spratt]]></surname>
<given-names><![CDATA[B.G]]></given-names>
</name>
<name>
<surname><![CDATA[Pardee]]></surname>
<given-names><![CDATA[A.B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Penicillin-binding proteins and cell shape in E. coli]]></article-title>
<source><![CDATA[Nature]]></source>
<year>1975</year>
<volume>254</volume>
<numero>516</numero>
<issue>516</issue>
</nlm-citation>
</ref>
<ref id="B75">
<label>75</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Delcour]]></surname>
<given-names><![CDATA[A.H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Outer membrane permeability and antibiotic resistance]]></article-title>
<source><![CDATA[Biochim. Biophys. Acta]]></source>
<year>2009</year>
<volume>1794</volume>
<numero>808</numero>
<issue>808</issue>
</nlm-citation>
</ref>
<ref id="B76">
<label>76</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[J.W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Ribonuclease P Database]]></article-title>
<source><![CDATA[Nucleic Acids Res]]></source>
<year>1999</year>
<volume>27</volume>
<numero>314</numero>
<issue>314</issue>
</nlm-citation>
</ref>
<ref id="B77">
<label>77</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shiying]]></surname>
<given-names><![CDATA[W.U]]></given-names>
</name>
<name>
<surname><![CDATA[Guanzhong]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kirsebom]]></surname>
<given-names><![CDATA[A. L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives]]></article-title>
<source><![CDATA[Biomolecules]]></source>
<year>2016</year>
<volume>6</volume>
<numero>38</numero>
<issue>38</issue>
</nlm-citation>
</ref>
<ref id="B78">
<label>78</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
<name>
<surname><![CDATA[Abebe]]></surname>
<given-names><![CDATA[L.S]]></given-names>
</name>
<name>
<surname><![CDATA[Millett]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of the respiration of multi-drug resistant clinical isolates ofMycobacterium tuberculosis by thiorida-zine: potential use for initial therapy of freshly diagnosed tuberculosis,/ Antimi-crob]]></article-title>
<source><![CDATA[Chemother]]></source>
<year>1996</year>
<volume>38</volume>
<numero>1049</numero>
<issue>1049</issue>
</nlm-citation>
</ref>
<ref id="B79">
<label>79</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reddy]]></surname>
<given-names><![CDATA[M.V]]></given-names>
</name>
<name>
<surname><![CDATA[Nadadhur]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Gangadharam]]></surname>
<given-names><![CDATA[P.R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In-vitro intracellular antimyco-bacterial activity of trifluoperazine]]></article-title>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>1996</year>
<volume>37</volume>
<numero>196</numero>
<issue>196</issue>
</nlm-citation>
</ref>
<ref id="B80">
<label>80</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gadre]]></surname>
<given-names><![CDATA[D.V]]></given-names>
</name>
<name>
<surname><![CDATA[Talwar]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro susceptibility testing of Mycobacterium tuberculosis strains to trifluoperazine]]></article-title>
<source><![CDATA[J. Chemother]]></source>
<year>1999</year>
<volume>11</volume>
<numero>203</numero>
<issue>203</issue>
</nlm-citation>
</ref>
<ref id="B81">
<label>81</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ratnakar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[S.P]]></given-names>
</name>
<name>
<surname><![CDATA[Sriramara]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Murthy]]></surname>
<given-names><![CDATA[P.S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Structure-antitubercular activity relationship of phenothiazine-type calmodulin antagonists]]></article-title>
<source><![CDATA[Int. Clin. Psychopharmacol]]></source>
<year>1995</year>
<volume>10</volume>
<numero>39</numero>
<issue>39</issue>
</nlm-citation>
</ref>
<ref id="B82">
<label>82</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bate]]></surname>
<given-names><![CDATA[A.B]]></given-names>
</name>
<name>
<surname><![CDATA[Kalin]]></surname>
<given-names><![CDATA[J.H]]></given-names>
</name>
<name>
<surname><![CDATA[Fooksman]]></surname>
<given-names><![CDATA[E.M]]></given-names>
</name>
<name>
<surname><![CDATA[Amorose]]></surname>
<given-names><![CDATA[E.L]]></given-names>
</name>
<name>
<surname><![CDATA[Price]]></surname>
<given-names><![CDATA[C.M]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[H.M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Synthesis and antitubercular activity of quaternized promazine and promethazine derivatives]]></article-title>
<source><![CDATA[Bioorg. Med. Chem. Lett]]></source>
<year>2007</year>
<volume>17</volume>
<numero>1346</numero>
<issue>1346</issue>
</nlm-citation>
</ref>
<ref id="B83">
<label>83</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bettencourt]]></surname>
<given-names><![CDATA[M.V]]></given-names>
</name>
<name>
<surname><![CDATA[Bosne-David]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2000</year>
<volume>16</volume>
<numero>69</numero>
<issue>69</issue>
</nlm-citation>
</ref>
<ref id="B84">
<label>84</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gadre]]></surname>
<given-names><![CDATA[D.V]]></given-names>
</name>
<name>
<surname><![CDATA[Talwar]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[H.C]]></given-names>
</name>
<name>
<surname><![CDATA[Murthy]]></surname>
<given-names><![CDATA[P.S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of trifluoperazine, a potential drug for tuberculosis with psychotic disorders, on the growth of clinical isolates of drug resistant Mycobacterium tuberculosis]]></article-title>
<source><![CDATA[Int. Clin. Psychopharmacol]]></source>
<year>1998</year>
<volume>13</volume>
<numero>129</numero>
<issue>129</issue>
</nlm-citation>
</ref>
<ref id="B85">
<label>85</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yano]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[L.S]]></given-names>
</name>
<name>
<surname><![CDATA[Weinstein]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Teh]]></surname>
<given-names><![CDATA[J.S]]></given-names>
</name>
<name>
<surname><![CDATA[Rubin]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Steady-state kinetics and inhibitory action of antitubercular phenothiazines on Mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2)]]></article-title>
<source><![CDATA[J. Biol. Chem]]></source>
<year>2006</year>
<volume>281</volume>
<numero>11456</numero>
<issue>11456</issue>
</nlm-citation>
</ref>
<ref id="B86">
<label>86</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saunders]]></surname>
<given-names><![CDATA[B.M]]></given-names>
</name>
<name>
<surname><![CDATA[Britton]]></surname>
<given-names><![CDATA[W.J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Life and death in the granuloma: immunopathology of tuberculosis]]></article-title>
<source><![CDATA[Immunol. Cell Biol]]></source>
<year>2007</year>
<volume>85</volume>
<numero>103</numero>
<issue>103</issue>
</nlm-citation>
</ref>
<ref id="B87">
<label>87</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Schelz]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Molnar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Hajos]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Riedl]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro and ex vivo activity of thioridazine derivatives against Mycobacterium tuberculosis]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2007</year>
<volume>29</volume>
<numero>338</numero>
<issue>338</issue>
</nlm-citation>
</ref>
<ref id="B88">
<label>88</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ordway]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Leandro]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Bettencourt]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Almeida]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical concentrations of thioridazine kill intracellular multidrugresistant Mycobacterium tuberculosis]]></article-title>
<source><![CDATA[Antimicrob. Agents Chemother]]></source>
<year>2003</year>
<volume>47</volume>
<numero>917</numero>
<issue>917</issue>
</nlm-citation>
</ref>
<ref id="B89">
<label>89</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weinstein]]></surname>
<given-names><![CDATA[E.A]]></given-names>
</name>
<name>
<surname><![CDATA[Yano]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[L.S]]></given-names>
</name>
<name>
<surname><![CDATA[Avarbock]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Avarbock]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Helm]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibitors of type II NADH: menaquinone oxidoreductase represents a class of antitubercular drugs]]></article-title>
<source><![CDATA[Proc. Natl. Acad. Sci. USA]]></source>
<year>2005</year>
<volume>102</volume>
<numero>4548</numero>
<issue>4548</issue>
</nlm-citation>
</ref>
<ref id="B90">
<label>90</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA['Non-antibiotics': alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries]]></article-title>
<source><![CDATA[Curr. Drug Targets]]></source>
<year>2006</year>
<volume>7</volume>
<numero>887</numero>
<issue>887</issue>
</nlm-citation>
</ref>
<ref id="B91">
<label>91</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Viveiros]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enhanced killing of intracellular multidru-g-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps]]></article-title>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>2007</year>
<volume>59</volume>
<numero>1237</numero>
<issue>1237</issue>
</nlm-citation>
</ref>
<ref id="B92">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amaral]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Kristiansen]]></surname>
<given-names><![CDATA[J.E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phenothiazines: an alternative to conventional therapy for the initial management of suspect multidrug resistance tuberculosis. A call for studies]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2000</year>
<volume>14</volume>
<numero>173</numero>
<issue>173</issue>
</nlm-citation>
</ref>
<ref id="B93">
<label>93</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kodavanti]]></surname>
<given-names><![CDATA[P.R]]></given-names>
</name>
<name>
<surname><![CDATA[Mundy]]></surname>
<given-names><![CDATA[W.R]]></given-names>
</name>
<name>
<surname><![CDATA[Tilson]]></surname>
<given-names><![CDATA[H.A]]></given-names>
</name>
<name>
<surname><![CDATA[Harry]]></surname>
<given-names><![CDATA[G.J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of selected neuro-active chemicals on calcium transporting systems in rat cerebellum and on survival of cerebellar granule cells]]></article-title>
<source><![CDATA[Fundam. Appl. Toxicol]]></source>
<year>1993</year>
<volume>21</volume>
<numero>308</numero>
<issue>308</issue>
</nlm-citation>
</ref>
<ref id="B94">
<label>94</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chitsaz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[M.H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role played by drug efflux pumps in bacterial multidrug resistance]]></article-title>
<source><![CDATA[EssaysBiochem]]></source>
<year>2017</year>
<volume>61</volume>
<numero>127</numero>
<issue>127</issue>
</nlm-citation>
</ref>
<ref id="B95">
<label>95</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhibin]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Yumei]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Yufan]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Yingying]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Lianhui]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[RND efflux pump and its interrelationship with quorum sensing system]]></article-title>
<source><![CDATA[Yi Chuan]]></source>
<year>2016</year>
<volume>38</volume>
<numero>894</numero>
<issue>894</issue>
</nlm-citation>
</ref>
<ref id="B96">
<label>96</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[P.J]]></given-names>
</name>
<name>
<surname><![CDATA[Sá-Correia]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Teixeira]]></surname>
<given-names><![CDATA[M.C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?]]></article-title>
<source><![CDATA[Front. Physiol]]></source>
<year>2014</year>
<volume>5</volume>
<numero>197</numero>
<issue>197</issue>
</nlm-citation>
</ref>
<ref id="B97">
<label>97</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lage]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[ABC-transporters: implications on drug resistance from microorganisms to human cancers]]></article-title>
<source><![CDATA[Int. J. Antimicrob. Agents]]></source>
<year>2003</year>
<volume>22</volume>
<numero>188</numero>
<issue>188</issue>
</nlm-citation>
</ref>
<ref id="B98">
<label>98</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[Y.J]]></given-names>
</name>
<name>
<surname><![CDATA[Saie Jr]]></surname>
<given-names><![CDATA[M.H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[SMR-type multidrug resistance pumps]]></article-title>
<source><![CDATA[Curr. Opin. DrugDiscov. Devel]]></source>
<year>2001</year>
<volume>4</volume>
<numero>237</numero>
<issue>237</issue>
</nlm-citation>
</ref>
<ref id="B99">
<label>99</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Handzlik]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Matys]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kiec-Kononowicz]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus]]></article-title>
<source><![CDATA[Antibiotics (Basel)]]></source>
<year>2013</year>
<volume>2</volume>
<numero>28</numero>
<issue>28</issue>
</nlm-citation>
</ref>
<ref id="B100">
<label>100</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miyamoto]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Balkovetz]]></surname>
<given-names><![CDATA[D.F]]></given-names>
</name>
<name>
<surname><![CDATA[Ganapathy]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Iwatsubo]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Hanano]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Leibach]]></surname>
<given-names><![CDATA[F.H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of phenothiazines on the Na+-H+ exchanger of the brush-border membrane from the proximal small intestine of the rabbit]]></article-title>
<source><![CDATA[J. Pharmacol. Exp. Ther]]></source>
<year>1988</year>
<volume>245</volume>
<numero>823</numero>
<issue>823</issue>
</nlm-citation>
</ref>
<ref id="B101">
<label>101</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roucou]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Manon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Guérin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Investigations of the inhibitory effect of propranolol, chlorpromazine, quinine, and dicyclohexylcarbodiimide on the swelling of yeast mitochondria in potassium acetate. Evidences for indirect effects mediated by the lipid phase]]></article-title>
<source><![CDATA[J. Bioenerg. Biomembr]]></source>
<year>1995</year>
<volume>27</volume>
<numero>353</numero>
<issue>353</issue>
</nlm-citation>
</ref>
<ref id="B102">
<label>102</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Toth]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Frase]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Antunes]]></surname>
<given-names><![CDATA[N.T]]></given-names>
</name>
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[C.A]]></given-names>
</name>
<name>
<surname><![CDATA[Vakulenko]]></surname>
<given-names><![CDATA[S.B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2''-Iva]]></article-title>
<source><![CDATA[Protein. Sci]]></source>
<year>2010</year>
<volume>19</volume>
<numero>1565</numero>
<issue>1565</issue>
</nlm-citation>
</ref>
<ref id="B103">
<label>103</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Madsen]]></surname>
<given-names><![CDATA[K.T]]></given-names>
</name>
<name>
<surname><![CDATA[Skov]]></surname>
<given-names><![CDATA[M.N]]></given-names>
</name>
<name>
<surname><![CDATA[Gill]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kemp]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Virulence Factors Associated with Enterococcus Faecalis Infective Endocarditis: A Mini Review]]></article-title>
<source><![CDATA[Open Microbiol. J]]></source>
<year>2017</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B104">
<label>104</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molnar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Mucsi]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Kasa]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Inhibition of the adhesion of E. coli on cultured human epithelial cells in the presence of promethazine or imipramine, Zentralbl]]></article-title>
<source><![CDATA[Bakteriol. Mikrobiol. Hyg]]></source>
<year>1983</year>
<volume>254</volume>
<numero>3883</numero>
<issue>3883</issue>
</nlm-citation>
</ref>
<ref id="B105">
<label>105</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Molnar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Csiszar]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Czirok]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Szollosy]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adhesion properties of E. coli cells in the presence of promethazine, Zentralbl]]></article-title>
<source><![CDATA[Bakteriol. Mikrobiol. Hyg]]></source>
<year>1987</year>
<volume>266</volume>
<numero>276</numero>
<issue>276</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
