<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182019000300528</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v48n3.84957</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Thermodynamic analysis of celecoxib in amphiprotic and amphiprotic-aprotic solvent mixtures at several temperatures]]></article-title>
<article-title xml:lang="es"><![CDATA[Análisis termodinámico del celecoxib en mezclas disolventes anfipróticas y anfipróticas-apróticas a varias temperaturas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña]]></surname>
<given-names><![CDATA[M. Ángeles]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escalera]]></surname>
<given-names><![CDATA[Begoña]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[Norma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Alcalá  ]]></institution>
<addr-line><![CDATA[Alcalá de Henares ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>48</volume>
<numero>3</numero>
<fpage>528</fpage>
<lpage>546</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182019000300528&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182019000300528&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182019000300528&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY The solubilities of celecoxib (CLX), a COX-2 selective nonsteroidal anti-inflammatory drug, were determined in water-ethanol and ethanol-ethyl acetate mixtures at several temperatures (288.15-308.15 K). The solubility curves as a function of ethanol ratio were studied at five temperatures, they showed a single maximum located at 50% ethanol-ethyl acetate (&#948;1 = 22.50 MPa1/2). The measurements of the variation of inherent drug solubility with temperature were used to estimate different thermodynamic parameters, enthalpy, entropy and Gibbs free energy of solution (&#916;H  S , &#916;S  S and &#916;G  S  hm , respectively). The apparent enthalpies of the solution were a nonlinear function of the ethanol ratio in aqueous mixture. Non-linear enthalpy-entropy compensation analysis was observed indicating different dissolution mechanism with the variation in mixtures composition. The solubility enhancement is entropy driven at water-rich region (0-40% v/v ethanol) and enthalpy controlled at ethanol-rich region (40-100% v/v ethanol), likely due to water-structure loss around nonpolar moieties of the drug and for the ethanol-rich mixtures it is the enthalpy, probably due to the drug better solvation.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Se determinó la solubilidad del celecoxib (CLX), un fármaco antiinflamatorio no esteroide selectivo de COX-2, en agua-etanol y etanol-acetato de etilo a varias temperaturas (288,15-308,15 K). Los perfiles de solubilidad obtenidos fueron estudiados en función de la proporción de etanol en las cinco temperaturas de estudio. Los resultados muestran solamente un máximo en el 50% de etanol-acetato de etilo (&#948;1 = 22,50 MPa1/2). La variación de la solubilidad con la temperatura se utilizó para calcular diferentes parámetros termodinámicos, entalpia, entropía y energía de disolución libre de Gibbs (&#916;H3, &#916;S  S y &#916;GS hm, respectivamente). Las entalpias aparentes de disolución fueron no lineales en la mezcla acuosa. Además, se observó un análisis de compensación de entalpía-entropía no lineal, lo que indica un mecanismo de disolución que varía con la composición de cada mezcla. El aumento de la solubilidad es impulsado por la entropía en la región rica en agua (0-40% v/v de etanol) y la entalpía en la región rica en etanol (40-100% v/v de etanol), probablemente debido a la pérdida de la estructura del agua alrededor de los residuos no polares del fármaco y para las mezclas ricas en etanol es la entalpía, probablemente debido a la mejor solvatación del fármaco.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[celecoxib]]></kwd>
<kwd lng="en"><![CDATA[solubility]]></kwd>
<kwd lng="en"><![CDATA[solvent mixtures]]></kwd>
<kwd lng="en"><![CDATA[thermodynamic quantities]]></kwd>
<kwd lng="en"><![CDATA[characterization]]></kwd>
<kwd lng="es"><![CDATA[celecoxib]]></kwd>
<kwd lng="es"><![CDATA[solubilidad]]></kwd>
<kwd lng="es"><![CDATA[mezcla disolvente]]></kwd>
<kwd lng="es"><![CDATA[parámetros termodinámicos]]></kwd>
<kwd lng="es"><![CDATA[caracterización]]></kwd>
</kwd-group>
</article-meta>
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