<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182020000100028</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v49n1.87004</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Estudo da composição química, toxicidade e atividade moluscicida do óleo essencial Citrus sinensis (L.) Osbeck]]></article-title>
<article-title xml:lang="en"><![CDATA[Study of the chemical composition, toxicity and molluscicidal activity of the essential oil Citrus sinensis (L.) Osbeck]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barros Gomes]]></surname>
<given-names><![CDATA[Paulo Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[da Costa Leite Júnior]]></surname>
<given-names><![CDATA[João de Deus]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de Sousa]]></surname>
<given-names><![CDATA[Dionney Andrade]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oliveira Everton]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Batista Reis]]></surname>
<given-names><![CDATA[Jonas]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Costa Louzeiro]]></surname>
<given-names><![CDATA[Hilton]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fontenele]]></surname>
<given-names><![CDATA[Maria Alves]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Livramento de Paula]]></surname>
<given-names><![CDATA[Maria do]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de Freitas]]></surname>
<given-names><![CDATA[Adriana Crispim]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lima Hunaldo]]></surname>
<given-names><![CDATA[Virlane Kelly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mouchrek Filho]]></surname>
<given-names><![CDATA[Victor Elias]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Federal de Educação, Ciência e Tecnologia do Pará  ]]></institution>
<addr-line><![CDATA[Abaetetuba PA]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal do Maranhão  ]]></institution>
<addr-line><![CDATA[São Luís MA]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal do Maranhão  ]]></institution>
<addr-line><![CDATA[Campus Pinheiro ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Federal do Maranhão  ]]></institution>
<addr-line><![CDATA[Imperatriz ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidade Federal do Maranhão Departamento de Farmácia ]]></institution>
<addr-line><![CDATA[São Luís MA]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>49</volume>
<numero>1</numero>
<fpage>28</fpage>
<lpage>43</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182020000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182020000100028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182020000100028&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO Determinamos a composição química e testamos a toxicidade e a atividade moluscicida do óleo essencial extraído das cascas do Citrus sinensis (L.) Osbeck. Para isso, o óleo essencial foi extraído quantitativamente por hidrodestilação. Em seguida, as quantificações de seus componentes foram realizadas por cromatografía gasosa acoplada à espectrometria de massas (CG-MS) e a toxicidade e atividade moluscicida foram testadas, respectivamente, contra Artemia salina e caramujos Biomphalaria glabrata. Os resultados mostraram que o óleo contém 81,50% de D-limoneno (constituinte principal) e 0,06% de citronelal (componente menor) e este possui atividade moluscicida com concentração letal (CL50) de 100,08 mg.L-1 e atoxicidade, com CL50 de 321,84 mg.L-1 a um nível de confiança de 95%. Portanto, o óleo é ativo contra o caramujo Biomphalariaglabrata e atóxico para outros seres vivos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY In this present study, we determined the chemical composition and we tested the toxicity and the molluscicidal activity of the essential oil extracted from the barks of Citrus sinensis (L.) Osbeck. For this, the essential oil was extracted quantitatively by hydrodistillation. Then, quantifications of its components were performed by gas chromatography coupled to mass spectrometry (CG-MS) and the toxicity and molluscicidal activity were tested, respectively, against Artemia salina and snails Biomphalaria glabrata. The results showed that the oil contains 81.50% of D-limonene (main constituent) and 0.06% of citronellal (minor component) and it has lethal activity (LC50) of 100.08 mg.L-1 and a toxicity, with LC50 of321.84 mg.L -1 at a 95% confidence level. Therefore, the oil is active against the snail Biomphalaria glabrata and non-toxic to other living bein.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Biomphalaria glabrata]]></kwd>
<kwd lng="pt"><![CDATA[hidrodestilação]]></kwd>
<kwd lng="pt"><![CDATA[compostos voláteis]]></kwd>
<kwd lng="pt"><![CDATA[Citrus sinensis (L.) Osbeck]]></kwd>
<kwd lng="pt"><![CDATA[esquistossomose]]></kwd>
<kwd lng="pt"><![CDATA[Artemia salina]]></kwd>
<kwd lng="en"><![CDATA[Biomphalaria glabrata]]></kwd>
<kwd lng="en"><![CDATA[hydrodistillation]]></kwd>
<kwd lng="en"><![CDATA[compounds voltiles]]></kwd>
<kwd lng="en"><![CDATA[Citrus sinensis (L.) Osbeck]]></kwd>
<kwd lng="en"><![CDATA[schistosomiasis]]></kwd>
<kwd lng="en"><![CDATA[Artemia salina]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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