<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182020000200329</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v49n2.89486</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Evaluation of physicochemical properties and dissolution studies on quality control of low water solubility drugs (raw materials and pharmaceutical formulations)]]></article-title>
<article-title xml:lang="es"><![CDATA[Evaluación de propiedades fisicoquímicas y estudios de disolución sobre el control de calidad de fármacos de baja solubilidad en agua (materias primas y formulaciones farmacéuticas)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[da Silva Ferreira]]></surname>
<given-names><![CDATA[Matheus]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de Carvalho Teles Júnior]]></surname>
<given-names><![CDATA[Gilmar Antônio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos Carvalho Júnior]]></surname>
<given-names><![CDATA[Carlos Magno]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de Souza Dias]]></surname>
<given-names><![CDATA[Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dias dos Santos Júnior]]></surname>
<given-names><![CDATA[Wilson Saback]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[da Guarda Souza]]></surname>
<given-names><![CDATA[Marluce Oliveira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de Freitas Santos Júnior]]></surname>
<given-names><![CDATA[Aníbal]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,University of Bahia (UNEB) Department of Exact and Earth Sciences (DCET) ]]></institution>
<addr-line><![CDATA[Salvador Bahia]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,State University of Bahia (UNEB) Department of Life Sciences (DCV) ]]></institution>
<addr-line><![CDATA[Salvador Bahia]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>49</volume>
<numero>2</numero>
<fpage>329</fpage>
<lpage>354</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182020000200329&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182020000200329&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182020000200329&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY The purpose of this study was to evaluate physicochemical properties and dissolution studies of furosemide (FUR), hydrochlorothiazide (HCTZ) and nifedipine (NIF), low water solubility drugs, in raw materials and pharmaceutical formulations. Surface and physicochemical characterization techniques -scanning electronic microscopy (SEM), thermogravimetry (TG), X-ray diffraction (XRD) and infrared (IR) spectrometry- as well as physical and physicochemical tests on tablets and capsules were applied as supporting information on drug quality control. Simple, rapid, and efficient UV-Vis methods were developed and validated for the determination of FUR, HCTZ and NIF samples. SEM exhibited considerable differences in the crystal morphological structures. Among the drugs studied, except for furosemide, more than one polymorph was present in the samples. Drug release profiles were satisfactory for all products. FUR and HCTZ tablets exhibited similar dissolution profiles, with very rapid release to the pharmaceutical specialties (reference, similar and generic). For HCTZ tablets, the similar drug (f2= 48.74) is not equivalent to the reference drug. NIF capsules (reference and compounded) showed a release &gt;80% of stated on product labels, in 10 minutes. The results obtained in this study suggest that the quality parameters and drug dissolution profiles may have been influenced by the morphology and size of the crystals, excipients, and technological processes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El propósito de este estudio fue evaluar las propiedades fisicoquímicas y los estudios de disolución de furosemida (FUR), hidroclorotiazida (HCTZ) y nifedipina (NIF), medicamentos de baja solubilidad en agua, en materias primas y formulaciones farmacéuticas. Técnicas de caracterización fisicoquímica y de superficie: microscopía electrónica de barrido (SEM), termogravimetría (TG), difracción de rayos X (XRD) y espectrometría infrarroja (IR), así como pruebas físicas y fisicoquímicas en tabletas y cápsulas que se aplicaron como información de apoyo sobre el control de calidad. Se desarrollaron y validaron métodos simples, rápidos y eficientes de UV-Vis para la determinación de muestras de FUR, HCTZ y NIF. SEM exhibió diferencias considerables en las estructuras morfológicas de cristal. Entre las drogas estudiadas, a excepción de la furosemida, más de un polimorfo estaba presente en las muestras. Los perfiles de liberación de fármacos fueron satisfactorios para todos los productos. Las tabletas FUR y HCTZ exhibieron perfiles de disolución similares, con una liberación muy rápida a las especialidades farmacéuticas (referencia, similares y genéricas). Para las tabletas de HCTZ, el medicamento similar (f2= 48,74) no es equivalente al medicamento de referencia. Las cápsulas NIF (de referencia y compuestas) mostraron una liberación &gt;80% de la indicada en las etiquetas del producto, en 10 minutos. Los resultados obtenidos en este estudio sugieren que los parámetros de calidad y los perfiles de disolución del fármaco pueden haber sido influenciados por la morfología y el tamaño de los cristales, excipientes y procesos tecnológicos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Drugs]]></kwd>
<kwd lng="en"><![CDATA[low water solubility]]></kwd>
<kwd lng="en"><![CDATA[physicochemical characterization]]></kwd>
<kwd lng="en"><![CDATA[dissolution]]></kwd>
<kwd lng="en"><![CDATA[quality control]]></kwd>
<kwd lng="es"><![CDATA[Drogas]]></kwd>
<kwd lng="es"><![CDATA[baja solubilidad en agua]]></kwd>
<kwd lng="es"><![CDATA[caracterización fisicoquímica]]></kwd>
<kwd lng="es"><![CDATA[disolución]]></kwd>
<kwd lng="es"><![CDATA[control de calidad]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anacleto]]></surname>
<given-names><![CDATA[S.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Borges]]></surname>
<given-names><![CDATA[M.M.C.]]></given-names>
</name>
<name>
<surname><![CDATA[de Oliveira]]></surname>
<given-names><![CDATA[H. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Vicente]]></surname>
<given-names><![CDATA[A. R.]]></given-names>
</name>
<name>
<surname><![CDATA[de Figueiredo]]></surname>
<given-names><![CDATA[E. C.]]></given-names>
</name>
<name>
<surname><![CDATA[de Oliveira]]></surname>
<given-names><![CDATA[M.A.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Borges]]></surname>
<given-names><![CDATA[B.J.P.]]></given-names>
</name>
<name>
<surname><![CDATA[de Oliveira]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Borges]]></surname>
<given-names><![CDATA[W.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Borges]]></surname>
<given-names><![CDATA[K.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of physicochemical properties as supporting information on quality control of raw materials and veterinary pharmaceutical formulations]]></article-title>
<source><![CDATA[J. Pharm. Anal]]></source>
<year>2018</year>
<volume>8</volume>
<page-range>168-75</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kesik-Brodacka]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progress in biopharmaceutical development]]></article-title>
<source><![CDATA[Biotechnol. Appl. Biochem]]></source>
<year>2018</year>
<volume>65</volume>
<page-range>306-22</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dahlgren]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Lennernás]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intestinal permeability and drug absorption: predictive experimental, computational and in vivo approaches]]></article-title>
<source><![CDATA[Pharmaceutics]]></source>
<year>2019</year>
<volume>11</volume>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santos Júnior]]></surname>
<given-names><![CDATA[A.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa]]></surname>
<given-names><![CDATA[I.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[V.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[R.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Caetite Junior]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Test of dissolution and comparison of in vitro dissolution profiles of coated ranitidine tablets marketed in Bahia, Brazil, Braz]]></article-title>
<source><![CDATA[J. Pharm. Sci]]></source>
<year>2014</year>
<volume>50</volume>
<page-range>83-9</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trivedi]]></surname>
<given-names><![CDATA[M.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Sethi]]></surname>
<given-names><![CDATA[K.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Panda]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Jana]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A comprehensive physicochemical, thermal, and spectroscopic characterization of zinc (II) chloride using X-ray diffraction, particle size distribution, differential scanning calorimetry, thermogravimetric analysis/differential thermogravimetric analysis, ultraviolet-visible, and Fourier transform-infrared Spectroscopy]]></article-title>
<source><![CDATA[Int. J. Pharm. Investig]]></source>
<year>2017</year>
<volume>7</volume>
<page-range>33-40</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leite]]></surname>
<given-names><![CDATA[R.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Macedo]]></surname>
<given-names><![CDATA[R.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[S.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Batista]]></surname>
<given-names><![CDATA[C.C.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Baltazar]]></surname>
<given-names><![CDATA[L.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Lima Neto]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[F.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of thermal stability and parameters of dissolution of nifedipine crystals]]></article-title>
<source><![CDATA[J. Therm. Anal. Calorim]]></source>
<year>2013</year>
<volume>111</volume>
<page-range>2117-23</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[R.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Semaan]]></surname>
<given-names><![CDATA[F.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Novák]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Cavalheiro]]></surname>
<given-names><![CDATA[E.T.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermal behavior of furosemide]]></article-title>
<source><![CDATA[J. Therm. Anal. Calorim]]></source>
<year>2013</year>
<volume>111</volume>
<page-range>1933-7</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[M.I.]]></given-names>
</name>
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[E.C.L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermal analysis applied to pharmaceuticals and pharmaceutical formulations in the pharmaceutical industry]]></article-title>
<source><![CDATA[Quím. Nova]]></source>
<year>2011</year>
<volume>34</volume>
<page-range>1224-30</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grooff]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[De Villiers]]></surname>
<given-names><![CDATA[M.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Liebenberg]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermal methods for evaluating polymorphic transitions in nifedipine]]></article-title>
<source><![CDATA[Thermochim. Acta]]></source>
<year>2007</year>
<volume>454</volume>
<page-range>33-42</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jendrzejewska]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Zajdel]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Pietrasik]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Barsova]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Goryczka]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Application of X-ray powder diffraction and differential scanning calorimetry for identification of counterfeit drugs]]></article-title>
<source><![CDATA[Monatsh. Chem]]></source>
<year>2018</year>
<volume>149</volume>
<page-range>977-85</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jagdale]]></surname>
<given-names><![CDATA[S.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Jadhav]]></surname>
<given-names><![CDATA[V.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Chabukswar]]></surname>
<given-names><![CDATA[A.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kuchekar]]></surname>
<given-names><![CDATA[B.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Solubility enhancement, physicochemical characterization and formulation of fast-dissolving tablet of nifedipine-betacyclodextrin complexes]]></article-title>
<source><![CDATA[Braz. J. Pharm. Sci]]></source>
<year>2012</year>
<volume>48</volume>
<page-range>131-45</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gallignani]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rondón]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ovalles]]></surname>
<given-names><![CDATA[J.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Brunetto]]></surname>
<given-names><![CDATA[M.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form]]></article-title>
<source><![CDATA[Acta Pharm. Sin. B]]></source>
<year>2014</year>
<volume>4</volume>
<page-range>376-83</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Badyal]]></surname>
<given-names><![CDATA[P.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Rawal]]></surname>
<given-names><![CDATA[R.K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Simultaneous estimation of hydrochlorothiazide, hydralazine hydrochloride, and reserpine using PCA, NAS, and NAS-PCA]]></article-title>
<source><![CDATA[Sci. Pharm]]></source>
<year>2015</year>
<volume>83</volume>
<page-range>599-610</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dinakaran]]></surname>
<given-names><![CDATA[S.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Alluria]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Annareddy]]></surname>
<given-names><![CDATA[K.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Ayyagari]]></surname>
<given-names><![CDATA[V.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Avasarala]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Kakaraparthy]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Chintamaneni]]></surname>
<given-names><![CDATA[P.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Gadi]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spectrophotometric method development and validation for atorvastatin calcium and nifedipine HCl in bulk and tablet dosage form using absorption ratio method assay of atorvastatin and nifedipine]]></article-title>
<source><![CDATA[J. Pharm. Res]]></source>
<year>2013</year>
<volume>7</volume>
<page-range>666-9</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vaculikova]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Cernikova]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Placha]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Pisarcik]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Peikertova]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Dedkova]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Devinsky]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Jampilek]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preparation of hydrochlorothiazide nanoparticles for solubility enhancement]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2016</year>
<volume>21</volume>
<numero>1005</numero>
<issue>1005</issue>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shariare]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Altamimi]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Marzan]]></surname>
<given-names><![CDATA[A.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Tabassum]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Jahan]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Reza]]></surname>
<given-names><![CDATA[H.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rahman]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ahsan]]></surname>
<given-names><![CDATA[G.U.]]></given-names>
</name>
<name>
<surname><![CDATA[Kazi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro dissolution and bioavailability study of furosemide nanosuspension prepared using design of experiment (DoE)]]></article-title>
<source><![CDATA[Saudi Pharm. J]]></source>
<year>2019</year>
<volume>27</volume>
<page-range>96-105</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tsume]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Mudie]]></surname>
<given-names><![CDATA[D.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Langguth]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Amidon]]></surname>
<given-names><![CDATA[G.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Amidon]]></surname>
<given-names><![CDATA[G.L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The biophar-maceutics classification system: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC]]></article-title>
<source><![CDATA[Eur. J. Pharm. Sci]]></source>
<year>2014</year>
<volume>57</volume>
<page-range>152-63</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amidon]]></surname>
<given-names><![CDATA[G.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Lennernas]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Shah]]></surname>
<given-names><![CDATA[V.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Crison]]></surname>
<given-names><![CDATA[J.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A theoretical basis for a bio-pharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability]]></article-title>
<source><![CDATA[Pharm. Res]]></source>
<year>1995</year>
<volume>12</volume>
<page-range>413-20</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ghadi]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Dand]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[BCS class IV drugs: highly notorious candidates for formulation development]]></article-title>
<source><![CDATA[J. Control. Release]]></source>
<year>2017</year>
<volume>248</volume>
<page-range>71-95</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[C.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biopharmaceutical innovation system and the influence of policies: the case of Taiwan (2000-2008)]]></article-title>
<source><![CDATA[Int. J. Health Policy Manag]]></source>
<year>2013</year>
<volume>1</volume>
<page-range>125-30</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cook]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Addicks]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[Y.H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Application of the biopharmaceutical classification system in clinical drug development-an industrial view]]></article-title>
<source><![CDATA[AAPS J]]></source>
<year>2008</year>
<volume>10</volume>
<page-range>306310</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="">
<collab>National List of Essential Medicines (RENAME)</collab>
<source><![CDATA[Ministry of Health of Brazil]]></source>
<year>2020</year>
</nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="">
<collab>Brazilian Health Surveillance Agency (ANVISA)</collab>
<source><![CDATA[Concepts and definitions of medicines]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barata-Silva]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Hauser-Davis]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[A.L.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Moreira]]></surname>
<given-names><![CDATA[J.C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Challenges to drug quality control in Brazil]]></article-title>
<source><![CDATA[Cad. Saúde Colet]]></source>
<year>2017</year>
<volume>25</volume>
<page-range>362-70</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="book">
<source><![CDATA[Brazilian Pharmacopeia]]></source>
<year>2019</year>
<edition>6rd</edition>
<publisher-loc><![CDATA[Brasília, Brazil ]]></publisher-loc>
<publisher-name><![CDATA[Brazilian Health Surveillance Agency (ANVISA)]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[M.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Viana]]></surname>
<given-names><![CDATA[L.C.M.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Sá]]></surname>
<given-names><![CDATA[R.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[F.A.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mota]]></surname>
<given-names><![CDATA[M.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Cazedey]]></surname>
<given-names><![CDATA[E.C.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[H.I.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos Júnior]]></surname>
<given-names><![CDATA[A.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparative in vitro analysis of dissolution profiles of furosemide tablets marketed in Bahia, Brazil]]></article-title>
<source><![CDATA[Lat. Am. J. Pharm]]></source>
<year>2016</year>
<volume>35</volume>
<page-range>2064-70</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Viana]]></surname>
<given-names><![CDATA[L.C.M.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[M.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Mota]]></surname>
<given-names><![CDATA[M.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Magalhães]]></surname>
<given-names><![CDATA[H.I.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos Júnior]]></surname>
<given-names><![CDATA[A.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Study of dissolution profiles and disintegration of tablets containing hydrochlorothiazide marketed in Bahia, Brazil]]></article-title>
<source><![CDATA[Lat. Am. J. Pharm]]></source>
<year>2015</year>
<volume>34</volume>
<page-range>2010-5</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="book">
<source><![CDATA[The United States Pharmacopeia]]></source>
<year>2018</year>
<edition>41rd</edition>
<publisher-loc><![CDATA[Rockville, Maryland, USA ]]></publisher-loc>
<publisher-name><![CDATA[United States Pharmacopeial Convention]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[K.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The concept of dissolution efficiency]]></article-title>
<source><![CDATA[J Pharm. Pharmacol]]></source>
<year>1975</year>
<volume>27</volume>
<page-range>48-9</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="book">
<collab>Brazilian Health Surveillance Agency (ANVISA)</collab>
<source><![CDATA[Resolution of the Board of Directors - RDC]]></source>
<year></year>
<numero>166</numero>
<issue>166</issue>
<publisher-name><![CDATA[Ministry of Health of Brazil]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="">
<collab>International Conference on Harmonization (ICH)</collab>
<source><![CDATA[Technical Requirements for Registration of Pharmaceuticals for Human Use - Validation of Analytical Procedures: Text and Methodology Q2(R1)]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saber]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Attia]]></surname>
<given-names><![CDATA[A.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Salem]]></surname>
<given-names><![CDATA[W.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermal analysis study of antihypertensive drugs telmisartan and cilazapril]]></article-title>
<source><![CDATA[Adv. Pharm. Bull]]></source>
<year>2014</year>
<volume>4</volume>
<page-range>283-7</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cides]]></surname>
<given-names><![CDATA[L.C.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Araújo]]></surname>
<given-names><![CDATA[A.A.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos-Filho]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[J.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermal behaviour, compatibility study and decomposition kinetics of glimepiride under isothermal and non-isothermal conditions]]></article-title>
<source><![CDATA[J. Therm. Anal. Calorim]]></source>
<year>2006</year>
<volume>84</volume>
<page-range>441-5</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[C.M.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[J.A.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Nascimento]]></surname>
<given-names><![CDATA[A.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Chaves Júnior]]></surname>
<given-names><![CDATA[J.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Ramos Júnior]]></surname>
<given-names><![CDATA[F.J.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Lima Neto]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[F.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Macedo]]></surname>
<given-names><![CDATA[R.O.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermal analysis study of solid dispersions hydrochlorothiazide]]></article-title>
<source><![CDATA[J. Therm. Anal. Calorim]]></source>
<year>2018</year>
<volume>131</volume>
<page-range>681-9</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Macedo]]></surname>
<given-names><![CDATA[R.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Nascimento]]></surname>
<given-names><![CDATA[T.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Veras]]></surname>
<given-names><![CDATA[J.W.E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparison of generic hydrochlorothiazide formulations by means of TG and DSC coupled to a photovisual system]]></article-title>
<source><![CDATA[J. Therm. Anal. Calorim]]></source>
<year>2001</year>
<volume>64</volume>
<page-range>757-63</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Filho]]></surname>
<given-names><![CDATA[R.O.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Franco]]></surname>
<given-names><![CDATA[P.I.B.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Conceição]]></surname>
<given-names><![CDATA[E.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Leles]]></surname>
<given-names><![CDATA[M.I.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stability studies on nifedipine tablets using thermogravimetry and differential scanning calorimetry]]></article-title>
<source><![CDATA[J. Therm. Anal. Calorim]]></source>
<year>2009</year>
<volume>97</volume>
<page-range>343-7</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Egusa]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Okazaki]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Schiewe]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Werthmann]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Wolkenhauer]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Identification of polymorphic forms of active pharmaceutical ingredient in low-concentration dry powder formulations by synchrotron X-Ray powder diffraction]]></article-title>
<source><![CDATA[Drugs R D]]></source>
<year>2017</year>
<volume>17</volume>
<page-range>413-8</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shin]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Physicochemical characterization of solid dispersion of furose-mide with TPGS]]></article-title>
<source><![CDATA[Int. J. Pharm]]></source>
<year>2003</year>
<volume>251</volume>
<page-range>79-84</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garnero]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Chattah]]></surname>
<given-names><![CDATA[A.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Longhi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stability of furosemide polymorphs and the effects of complex formation with &#946;-cyclodextrin and maltodextrin]]></article-title>
<source><![CDATA[Carbohyd. Polym]]></source>
<year>2016</year>
<volume>152</volume>
<page-range>598-604</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garnero]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Chattah]]></surname>
<given-names><![CDATA[A.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Longhi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Supramolecular complexes of maltodextrin and furosemide polymorphs: a new approach for delivery systems]]></article-title>
<source><![CDATA[Carbohyd. Polym]]></source>
<year>2013</year>
<volume>94</volume>
<page-range>292-300</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villiers]]></surname>
<given-names><![CDATA[M.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Watt]]></surname>
<given-names><![CDATA[J.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Lötter]]></surname>
<given-names><![CDATA[A.P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Kinetic study of the solid-state photolytic degradation of two polymorphic forms of Furosemide]]></article-title>
<source><![CDATA[Int. J. Pharm]]></source>
<year>1992</year>
<volume>88</volume>
<page-range>275283</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Matsuda]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Tatsumi]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Physicochemical characterization of furosemide modifications]]></article-title>
<source><![CDATA[Int. J. Pharm]]></source>
<year>1990</year>
<volume>60</volume>
<page-range>11-26</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[El-Gizawy]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Osman]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Arafa]]></surname>
<given-names><![CDATA[M.F.]]></given-names>
</name>
<name>
<surname><![CDATA[El Maghraby]]></surname>
<given-names><![CDATA[G.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aerosil as a novel co-crystal co-former for improving the dissolution rate of Hydrochlorothiazide]]></article-title>
<source><![CDATA[Int. J. Pharm]]></source>
<year>2015</year>
<volume>478</volume>
<page-range>773-8</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aceves-Hernández]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Agacino-Valdés]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Paz]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hinojosa-Torres]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Experimental and theoretical study of the conformational analysis of Hydrochlorothiazide]]></article-title>
<source><![CDATA[J. Mol. Struct]]></source>
<year>2006</year>
<volume>786</volume>
<page-range>1-8</page-range></nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chinh]]></surname>
<given-names><![CDATA[N.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Trang]]></surname>
<given-names><![CDATA[N.T.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Giang]]></surname>
<given-names><![CDATA[N.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Thanh]]></surname>
<given-names><![CDATA[D.T.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Hang]]></surname>
<given-names><![CDATA[T.T.X.]]></given-names>
</name>
<name>
<surname><![CDATA[Tung]]></surname>
<given-names><![CDATA[N.Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Truyen]]></surname>
<given-names><![CDATA[C.Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Quan]]></surname>
<given-names><![CDATA[P.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Long]]></surname>
<given-names><![CDATA[P.Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Hoang]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[In vitro nifedipine release from poly(lactic acid)/chitosan nanoparticles loaded with nifedipine]]></article-title>
<source><![CDATA[J. Appl. Polym. Sci]]></source>
<year>2016</year>
<volume>133</volume>
<page-range>43330</page-range></nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[M.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Glass]]></surname>
<given-names><![CDATA[B.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Worthington]]></surname>
<given-names><![CDATA[M.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Binary systems of nifedipine and various cyclodextrins in the solid state. Thermal, FTIR, XRD studies]]></article-title>
<source><![CDATA[J. Therm. Anal. Calorim]]></source>
<year>2002</year>
<volume>68</volume>
<page-range>631-46</page-range></nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gallignani]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rondón]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ovalles]]></surname>
<given-names><![CDATA[J.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Brunetto]]></surname>
<given-names><![CDATA[M.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form]]></article-title>
<source><![CDATA[Acta Pharm. Sin. B]]></source>
<year>2014</year>
<volume>4</volume>
<page-range>376-83</page-range></nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bunaciu]]></surname>
<given-names><![CDATA[A.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Aboul-Enein]]></surname>
<given-names><![CDATA[H.Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Fleschin]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Application of Fourier transform infrared spectrophotometry in pharmaceutical drugs analysis]]></article-title>
<source><![CDATA[Appl. Spectrosc. Rev]]></source>
<year>2010</year>
<volume>45</volume>
<page-range>206-19</page-range></nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Doherty]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[York]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fresemide crystal forms; solid state and physicochemical analyses]]></article-title>
<source><![CDATA[Int. J. Pharm]]></source>
<year>1988</year>
<volume>47</volume>
<page-range>141-55</page-range></nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sonpal]]></surname>
<given-names><![CDATA[R.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Shelat]]></surname>
<given-names><![CDATA[P.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Lalwani]]></surname>
<given-names><![CDATA[A.N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Solubility enhancement of hydrochlorothiazide using a novel drug-drug solid dispersion technology]]></article-title>
<source><![CDATA[Int. J. Pharm. Sci. Nanotech]]></source>
<year>2015</year>
<volume>8</volume>
<page-range>2924-36</page-range></nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Razzaq]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Ranjha]]></surname>
<given-names><![CDATA[N.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Rashid]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Nasir]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preparation, and evaluation of novel pH-sensitive poly(butyl acrylate-co-itaconic acid) hydrogel microspheres for controlled drug delivery]]></article-title>
<source><![CDATA[Adv. Polym. Tech]]></source>
<year>2018</year>
<volume>37</volume>
<page-range>21663</page-range></nlm-citation>
</ref>
<ref id="B52">
<label>52</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ricarte]]></surname>
<given-names><![CDATA[R.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Lodge]]></surname>
<given-names><![CDATA[T.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Hillmyer]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Detection of pharmaceutical drug crystallites in solid dispersions by transmission electron microscopy]]></article-title>
<source><![CDATA[Mol. Pharmaceutics]]></source>
<year>2015</year>
<volume>12</volume>
<page-range>983-90</page-range></nlm-citation>
</ref>
<ref id="B53">
<label>53</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mantas]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Mihranyan]]></surname>
<given-names><![CDATA[A.T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immediate-release nifedipine binary dry powder mixtures with nanocellulose featuring enhanced solubility and dissolution rate]]></article-title>
<source><![CDATA[Pharmaceutics]]></source>
<year>2019</year>
<volume>11</volume>
</nlm-citation>
</ref>
<ref id="B54">
<label>54</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sadr]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Nabipour]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preparation and identification of furosemide nanoparticles]]></article-title>
<source><![CDATA[J. Basic Appl. Sci. Res]]></source>
<year>2013</year>
<volume>3</volume>
<page-range>666-70</page-range></nlm-citation>
</ref>
<ref id="B55">
<label>55</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Osei-Yeboah]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[C.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Validation and applications of an expedited tablet friability method]]></article-title>
<source><![CDATA[Int.J. Pharm]]></source>
<year>2015</year>
<volume>484</volume>
<page-range>146-55</page-range></nlm-citation>
</ref>
<ref id="B56">
<label>56</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paul]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[C.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The suitability of common compressibility equations for characterizing plasticity of diverse powders]]></article-title>
<source><![CDATA[Int. J. Pharm]]></source>
<year>2017</year>
<volume>532</volume>
<page-range>124-30</page-range></nlm-citation>
</ref>
<ref id="B57">
<label>57</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pignato]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Birnie]]></surname>
<given-names><![CDATA[C.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analysis of compounded pharmaceutical products to teach the importance of quality in an applied pharmaceutics laboratory course]]></article-title>
<source><![CDATA[Am. J. Pharm. Educ]]></source>
<year>2014</year>
<volume>78</volume>
<page-range>61</page-range></nlm-citation>
</ref>
<ref id="B58">
<label>58</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rajkumar]]></surname>
<given-names><![CDATA[A.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Reynolds]]></surname>
<given-names><![CDATA[G.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Wren]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Hounslow]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Salman]]></surname>
<given-names><![CDATA[A.D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Investigating the effect of processing parameters on pharmaceutical tablet disintegration using a real-time particle imaging approach]]></article-title>
<source><![CDATA[Eur. J. Pharm. Biopharm]]></source>
<year>2016</year>
<volume>106</volume>
<page-range>88-96</page-range></nlm-citation>
</ref>
<ref id="B59">
<label>59</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Soares]]></surname>
<given-names><![CDATA[L.A.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Schmidt]]></surname>
<given-names><![CDATA[P.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Ortega]]></surname>
<given-names><![CDATA[G.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Petrovick]]></surname>
<given-names><![CDATA[P.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of compression strength and speed on the properties of tablets containing high concentration of dry plant extract]]></article-title>
<source><![CDATA[Acta Farm. Bonaerense]]></source>
<year>2003</year>
<volume>22</volume>
<page-range>147-54</page-range></nlm-citation>
</ref>
<ref id="B60">
<label>60</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[A.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Michelin]]></surname>
<given-names><![CDATA[D.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[M.R.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Paganelli]]></surname>
<given-names><![CDATA[M.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Ignácio]]></surname>
<given-names><![CDATA[R.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Chaud]]></surname>
<given-names><![CDATA[M.V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Compression force and humidity on hydrochlorothiazide dissolution profile]]></article-title>
<source><![CDATA[Acta Farm. Bonaerense]]></source>
<year>2006</year>
<volume>25</volume>
<page-range>104-7</page-range></nlm-citation>
</ref>
<ref id="B61">
<label>61</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anand]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[L.X.]]></given-names>
</name>
<name>
<surname><![CDATA[Conner]]></surname>
<given-names><![CDATA[D.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Davit]]></surname>
<given-names><![CDATA[B.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dissolution testing for generic drugs: an FDA perspective]]></article-title>
<source><![CDATA[AAPS J]]></source>
<year>2011</year>
<volume>13</volume>
<page-range>328-35</page-range></nlm-citation>
</ref>
<ref id="B62">
<label>62</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rumel]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Nishioka]]></surname>
<given-names><![CDATA[S.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[A.A.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug interchangeability: clinical approach and consumer's point of view]]></article-title>
<source><![CDATA[Rev. Saude Publica]]></source>
<year>2006</year>
<volume>40</volume>
<page-range>921-7</page-range></nlm-citation>
</ref>
<ref id="B63">
<label>63</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menegola]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Steppe]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Schapoval]]></surname>
<given-names><![CDATA[E.E.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dissolution test for citalopram in tablets and comparison of in vitro dissolution profiles]]></article-title>
<source><![CDATA[Eur. J. Pharm. Biopharm]]></source>
<year>2007</year>
<volume>67</volume>
<page-range>524-30</page-range></nlm-citation>
</ref>
<ref id="B64">
<label>64</label><nlm-citation citation-type="book">
<collab>Brazilian Health Surveillance Agency (ANVISA)</collab>
<source><![CDATA[Resolution of the Board of Directors (RDC)]]></source>
<year></year>
<numero>31</numero>
<issue>31</issue>
<publisher-name><![CDATA[Ministry of Health of Brazil]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B65">
<label>65</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[K.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Aléssio]]></surname>
<given-names><![CDATA[P.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[A.J.P.S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Specific excipient development for prepared nifedipine capsules masterfully]]></source>
<year>2009</year>
<volume>30</volume>
<page-range>257-61</page-range></nlm-citation>
</ref>
<ref id="B66">
<label>66</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Maria]]></surname>
<given-names><![CDATA[E.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Gomes]]></surname>
<given-names><![CDATA[A.J.P.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nifedipine manipulated or pharmaceutical specialty?]]></article-title>
<source><![CDATA[In vitro study, Rev. Eletronica Farm]]></source>
<year>2008</year>
<volume>5</volume>
<page-range>31-6</page-range></nlm-citation>
</ref>
<ref id="B67">
<label>67</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silveira]]></surname>
<given-names><![CDATA[G.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[L.D.]]></given-names>
</name>
<name>
<surname><![CDATA[V.C.F.]]></surname>
<given-names><![CDATA[Mosqueira]]></given-names>
</name>
<name>
<surname><![CDATA[Souza]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Biopharmaceutical evaluation of reference, generic, similar and magisterial medicines containing furose-mide, one lower solubility and lower permeability drug]]></article-title>
<source><![CDATA[Rev. Bras. Farm]]></source>
<year>2011</year>
<volume>92</volume>
<page-range>306-13</page-range></nlm-citation>
</ref>
<ref id="B68">
<label>68</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lamolha]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[A.C.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[B.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Granata]]></surname>
<given-names><![CDATA[F.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Podavin]]></surname>
<given-names><![CDATA[G.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[J.C.O.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of pharmaceutical equivalence of furosemide 40mg tablets]]></article-title>
<source><![CDATA[Rev. Bras. Farm]]></source>
<year>2012</year>
<volume>93</volume>
<page-range>17-21</page-range></nlm-citation>
</ref>
<ref id="B69">
<label>69</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahle]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Goelzer]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Adriano]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Felippe]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Vier]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Carli]]></surname>
<given-names><![CDATA[R.B.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Couto]]></surname>
<given-names><![CDATA[A.G]]></given-names>
</name>
<name>
<surname><![CDATA[Lucinda-Silva]]></surname>
<given-names><![CDATA[R.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of the tablet dissolution profile of hydrochlorothiazide marketed in Brazil]]></article-title>
<source><![CDATA[Rev. Cienc. Farm. Basica Apl]]></source>
<year>2007</year>
<volume>28</volume>
<page-range>265-71</page-range></nlm-citation>
</ref>
<ref id="B70">
<label>70</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[M.S]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[C.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[S.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[C.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Wen]]></surname>
<given-names><![CDATA[K.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A comparative study on the dissolution profiles of commercial hydrochlorothiazide tablets]]></article-title>
<source><![CDATA[J. Food Drug. Anal]]></source>
<year>2002</year>
<volume>10</volume>
<page-range>18-24</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
