<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182020000200482</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v49n2.89923</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[The selective obtaining of amyrins from Amazonian Protium oleoresins]]></article-title>
<article-title xml:lang="es"><![CDATA[La obtención selectiva de amirinas a partir de oleorresinas de Protium amazónicas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gomes da Silva Ferreira]]></surname>
<given-names><![CDATA[Rosilene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guühon-Simplicio]]></surname>
<given-names><![CDATA[Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[de Lima Yamaguchi]]></surname>
<given-names><![CDATA[Klenicy Kazumy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte de Lira]]></surname>
<given-names><![CDATA[Priscila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marques Machado]]></surname>
<given-names><![CDATA[Tallita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Couto Ferreira]]></surname>
<given-names><![CDATA[Márcio Antônio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[da Veiga-Junior]]></surname>
<given-names><![CDATA[Valdir Florêncio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva Lima]]></surname>
<given-names><![CDATA[Emerson]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade do Estado do Amazonas  ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal do Amazonas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade do Estado do Amazonas  ]]></institution>
<addr-line><![CDATA[Coari Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Federal do Amazonas  ]]></institution>
<addr-line><![CDATA[Manaus Amazonas]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Instituto Militar de Engenharia Departamento de Engenharia Química ]]></institution>
<addr-line><![CDATA[Rio de Janeiro ]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>49</volume>
<numero>2</numero>
<fpage>482</fpage>
<lpage>497</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182020000200482&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182020000200482&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182020000200482&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY The oleoresin produced by species of genus Protium sp. is rich in alpha and betaamyrins, two triterpenes with many pharmacogical activities. Considering the need to make the improved obtainment of these products feasible, this study sought to optimize techniques for the extraction and isolation of amyrins from resin. Two methods of extraction (maceration and sonication) with different solvents were compared to direct isolation from crude resin. The isolation of triterpenes was performed by chromatographic columns and the yields of extracts and fractions were analyzed by analysis of variance. The best extraction solvent for amyrins was hexane for both maceration and sonication methods (38.16±2.06% and 37.67±8.21%, respectively). There was no statistical difference between these methods and the direct method (32.05±2.40%). Additionally, the direct method is cheaper and more environmentally friendly. Thus, this study showed that it is possible to obtain a large quantity of amyrins by means of cheap, fast and ecological methods.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La oleorresina producida por especies del género Protium sp. es rica en amirinas alfa y beta, dos triterpenos con muchas actividades farmacológicas. Esta investigación buscó optimizar las técnicas de extracción y aislamiento de amirinas de la resina para hacer factible la obtención mejorada de esos productos. Se compararon dos métodos de extracción (maceración y sonicación) con diferentes solventes con aislamiento directo de la resina cruda. El aislamento de los triterpenos se realizó mediante columnas cromatográficas y los rendimientos de extractos y fracciones fueron hechos mediante análisis de varianza. El mejor solvente para la extracción de amirinas fue el hexano para ambos métodos de maceración y sonicación (38,16±2,06% y 37,67±8,21%, respectivamente). No hubo diferencia estadística entre estos métodos y el método directo (32,05±2,40%). Además, el método directo es más barato y ecológico. De este modo, esta investigación demostró que es posible obtener una gran cantidad de amirinas a través de métodos rápidos, baratos y ecológicos.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Protium]]></kwd>
<kwd lng="en"><![CDATA[alpha and beta-amyrins]]></kwd>
<kwd lng="en"><![CDATA[yielding extraction]]></kwd>
<kwd lng="en"><![CDATA[extraction optimization]]></kwd>
<kwd lng="es"><![CDATA[Protium]]></kwd>
<kwd lng="es"><![CDATA[amirinas alfa y beta]]></kwd>
<kwd lng="es"><![CDATA[rendimientos de extracción]]></kwd>
<kwd lng="es"><![CDATA[optimización de extracción]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[da Silva]]></surname>
<given-names><![CDATA[E.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[D.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandes]]></surname>
<given-names><![CDATA[P.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Bizzo]]></surname>
<given-names><![CDATA[H.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Leitão]]></surname>
<given-names><![CDATA[S.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ethnopharmacological evaluation of breu essential oils from Protium Species administered by inhalation]]></article-title>
<source><![CDATA[J. Evid. Based. Complementary Altern. Med]]></source>
<year>2017</year>
<volume>2017</volume>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[E.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Nascimento]]></surname>
<given-names><![CDATA[A.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Lenz]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Scherer]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Meyrelles]]></surname>
<given-names><![CDATA[S.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Boëchat]]></surname>
<given-names><![CDATA[G.A.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Andrade]]></surname>
<given-names><![CDATA[T.U.]]></given-names>
</name>
<name>
<surname><![CDATA[Endringer]]></surname>
<given-names><![CDATA[D.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Triterpenes from the Protium heptaphyllum resin - chemical composition and cytotoxicity]]></article-title>
<source><![CDATA[Rev. Bras. Farmacogn]]></source>
<year>2014</year>
<volume>24</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>399-407</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lorenzi]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Arvores brasileiras: manual de identificação e cultivo de plantas nativas do Brasil, Plantarum]]></article-title>
<source><![CDATA[Nova Odessa]]></source>
<year>1992</year>
<volume>1</volume>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rüdiger]]></surname>
<given-names><![CDATA[A.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[C.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Veiga Júnior]]></surname>
<given-names><![CDATA[V.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[EDXRF Analysis ofAmazonian Burseraceae oleoresins]]></article-title>
<source><![CDATA[J. Braz. Chem. Soc]]></source>
<year>2009</year>
<volume>20</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1077-81</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Furtado]]></surname>
<given-names><![CDATA[N.A.J.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Pirson]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Edelberg]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Miranda]]></surname>
<given-names><![CDATA[L.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Loira-Pastoriza]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Preat]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Larondelle]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[André]]></surname>
<given-names><![CDATA[C.M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pentacyclic triterpene bioavailability: an overview of in vitro and in vivo studies]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2017</year>
<volume>22</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>400</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rüdiger]]></surname>
<given-names><![CDATA[A.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Siani]]></surname>
<given-names><![CDATA[A.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Veiga Júnior]]></surname>
<given-names><![CDATA[V.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The chemistry and pharmacology of the South America genus Protium Burm F (Burseraceae)]]></article-title>
<source><![CDATA[Pharmacogn. Rev]]></source>
<year>2007</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>93-104</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Vázquez]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Mangas]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Palazón]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Navarro-Ocaña]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Valuable medicinal plants and resins: Commercial phytochemicals with bioactive properties]]></article-title>
<source><![CDATA[Ind. Crops Prod]]></source>
<year>2010</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>476-80</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Biskup]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Golçbiowski]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gniadecki]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Stepnowski]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Lojkowska]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Triter-penoid a-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage]]></article-title>
<source><![CDATA[Acta Biochim. Pol]]></source>
<year>2012</year>
<volume>59</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>255-60</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lima-Júnior]]></surname>
<given-names><![CDATA[R.C.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[D.I.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[G.A.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Cunha]]></surname>
<given-names><![CDATA[C.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Chaves]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[V.S.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[F.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Modulation of acute visceral nociception and bladder inflammation by plant triterpene, &#945;, &#946;-amyrin in a mouse model of cystitis: role of tachykinin NK1-receptors, and K+ATP channels]]></article-title>
<source><![CDATA[Inflamm. Res]]></source>
<year>2007</year>
<volume>56</volume>
<page-range>487-94</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Matos]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Bento]]></surname>
<given-names><![CDATA[A.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Marcon]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Claudino]]></surname>
<given-names><![CDATA[R.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Calixto]]></surname>
<given-names><![CDATA[J.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preventive and therapeutic oral administration of the pentacyclic triterpene &#945;, &#946;-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: the relevance of cannabinoid system]]></article-title>
<source><![CDATA[Mol. Immunol]]></source>
<year>2013</year>
<volume>54</volume>
<numero>3-4</numero>
<issue>3-4</issue>
<page-range>482-92</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Medeiros]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Otuki]]></surname>
<given-names><![CDATA[M.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Avellar]]></surname>
<given-names><![CDATA[M.C.W.]]></given-names>
</name>
<name>
<surname><![CDATA[Calixto]]></surname>
<given-names><![CDATA[J.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanisms underlying the inhibitory actions of the pentacyclic triterpene &#945;-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate]]></article-title>
<source><![CDATA[Eur. J. Pharmacol]]></source>
<year>2007</year>
<volume>559</volume>
<numero>2-3</numero>
<issue>2-3</issue>
<page-range>227-35</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Melo]]></surname>
<given-names><![CDATA[C.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Morais]]></surname>
<given-names><![CDATA[T.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Tomé]]></surname>
<given-names><![CDATA[A.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[G.A.C]]></given-names>
</name>
<name>
<surname><![CDATA[Chaves]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[V.S]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[F.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-inflammatory effect of &#945;,&#946;-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice]]></article-title>
<source><![CDATA[Inflamm. Res]]></source>
<year>2011</year>
<volume>60</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>673-81</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[A.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[Y.I.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Adjafre]]></surname>
<given-names><![CDATA[B.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Moraes]]></surname>
<given-names><![CDATA[M.E.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Aragão]]></surname>
<given-names><![CDATA[G.F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review]]></article-title>
<source><![CDATA[Fundam. Clin. Pharmacol]]></source>
<year>2019</year>
<volume>33</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>4-12</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Okoye]]></surname>
<given-names><![CDATA[K.K.]]></given-names>
</name>
<name>
<surname><![CDATA[Ajaghaku]]></surname>
<given-names><![CDATA[D.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Okeke]]></surname>
<given-names><![CDATA[H.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Ilodigwe]]></surname>
<given-names><![CDATA[E.E.]]></given-names>
</name>
<name>
<surname><![CDATA[Nworu]]></surname>
<given-names><![CDATA[C.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Okoye]]></surname>
<given-names><![CDATA[F.B.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Beta-amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity]]></article-title>
<source><![CDATA[Pharm. Biol]]></source>
<year>2014</year>
<volume>52</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1478-86</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Otuki]]></surname>
<given-names><![CDATA[M.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Vieira-Lima]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Malheiros]]></surname>
<given-names><![CDATA[Â.]]></given-names>
</name>
<name>
<surname><![CDATA[Yunes]]></surname>
<given-names><![CDATA[R.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Clixto]]></surname>
<given-names><![CDATA[J.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Topical antiinflammatory effects of the ether extract from Protium kleinii and &#945;-amyrin pentacyclic triterpene]]></article-title>
<source><![CDATA[Eur. J. Pharmacol]]></source>
<year>2005</year>
<volume>507</volume>
<numero>1-3</numero>
<issue>1-3</issue>
<page-range>253-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[F.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Frota]]></surname>
<given-names><![CDATA[J.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Arruda]]></surname>
<given-names><![CDATA[B.R.]]></given-names>
</name>
<name>
<surname><![CDATA[de Melo]]></surname>
<given-names><![CDATA[T.S.]]></given-names>
</name>
<name>
<surname><![CDATA[da Silva]]></surname>
<given-names><![CDATA[A.A.C.A]]></given-names>
</name>
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[G.A.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Chaves]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[V.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antihyperglycemic and hypolipidemic effects of &#945;, &#946;-amyrin, a triterpenoid mixture from Protium heptaphyllum in mice]]></article-title>
<source><![CDATA[Lipids Health Dis]]></source>
<year>2012</year>
<volume>11</volume>
<numero>98</numero>
<issue>98</issue>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shih]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Cherng]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reduction of adhesion molecule production and alteration of eNOS and endothelin-1 mRNA expression in endothelium by Euphorbia hirta L. through its beneficial &#946;-amyrin molecule]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2014</year>
<volume>19</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>10534-45</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gullón]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Gullón]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Lú-Chau]]></surname>
<given-names><![CDATA[T.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Moreira]]></surname>
<given-names><![CDATA[M.T.]]></given-names>
</name>
<name>
<surname><![CDATA[Lema]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Eibes]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Optimization of solvent extraction of antioxidants from Eucalyptus globulus leaves by response surface methodology: characterization and assessment of their bioactive properties]]></article-title>
<source><![CDATA[Ind. Crops Prod]]></source>
<year>2017</year>
<volume>108</volume>
<page-range>649-59</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodríguez-Rojo]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Visentin]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Maestri]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Cocero]]></surname>
<given-names><![CDATA[M.J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Assisted extraction of rosemary antioxidantes qith green solvents]]></article-title>
<source><![CDATA[J. Food Eng]]></source>
<year>2012</year>
<volume>109</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>98-103</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roriz]]></surname>
<given-names><![CDATA[C.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Barros]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Prieto]]></surname>
<given-names><![CDATA[M.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Barreiro]]></surname>
<given-names><![CDATA[M.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Morales]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[I.C.F.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Modern extraction techniques optimized to extract betacyanins from Gomphrena globosa L.]]></article-title>
<source><![CDATA[Ind. Crops Prod]]></source>
<year>2017</year>
<volume>105</volume>
<page-range>29-40</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aragão]]></surname>
<given-names><![CDATA[G.F.]]></given-names>
</name>
<name>
<surname><![CDATA[Pinheiro]]></surname>
<given-names><![CDATA[M.C.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Bandeira]]></surname>
<given-names><![CDATA[P.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Lemos]]></surname>
<given-names><![CDATA[T.L.G]]></given-names>
</name>
<name>
<surname><![CDATA[Viana]]></surname>
<given-names><![CDATA[G.S.B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analgesic and anti-inflammatory activities of the isomeric mixture of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March]]></article-title>
<source><![CDATA[J. Herb. Pharmacother]]></source>
<year>2008</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>31-47</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bandeira]]></surname>
<given-names><![CDATA[P.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Lemos]]></surname>
<given-names><![CDATA[T.L.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Costa]]></surname>
<given-names><![CDATA[S.M.O.]]></given-names>
</name>
<name>
<surname><![CDATA[dos Santos]]></surname>
<given-names><![CDATA[H.S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Obtenção de derivados da mistura triterpenoídica &#945;- e &#946;-amirina]]></article-title>
<source><![CDATA[Rev. Bras. Farmacogn]]></source>
<year>2007</year>
<volume>17</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>204-8</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wagh]]></surname>
<given-names><![CDATA[S.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Gujar]]></surname>
<given-names><![CDATA[J.G.]]></given-names>
</name>
<name>
<surname><![CDATA[Gaikar]]></surname>
<given-names><![CDATA[V.G.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Experimental and modeling studies on extraction of amyrins from latex of mandar (Calotropis gigantea)]]></article-title>
<source><![CDATA[Indian J. Chem. Technol]]></source>
<year>2012</year>
<volume>19</volume>
<page-range>427-33</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carvalho]]></surname>
<given-names><![CDATA[K.M.M.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Marinho Filho]]></surname>
<given-names><![CDATA[J.D.B.]]></given-names>
</name>
<name>
<surname><![CDATA[de Melo]]></surname>
<given-names><![CDATA[T.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Araújo]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Quetz]]></surname>
<given-names><![CDATA[J.D.S.]]></given-names>
</name>
<name>
<surname><![CDATA[da Cunha]]></surname>
<given-names><![CDATA[M.D.P.S.S]]></given-names>
</name>
<name>
<surname><![CDATA[de Melo]]></surname>
<given-names><![CDATA[K.M.]]></given-names>
</name>
<name>
<surname><![CDATA[da Silva]]></surname>
<given-names><![CDATA[A.A.D.C.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Tomé]]></surname>
<given-names><![CDATA[A.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Havt]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[S.G.D.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Brito]]></surname>
<given-names><![CDATA[G.A.D.C.]]></given-names>
</name>
<name>
<surname><![CDATA[Chaves]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[V.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[F.A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The resin from Protium heptaphyllum prevents high-fat diet-induced obesity in mice: scientific evidence and potential mechanisms]]></article-title>
<source><![CDATA[J. Evid. Based Complementary Altern. Med]]></source>
<year>2015</year>
<volume>2015</volume>
<page-range>106-57</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vieira Júnior]]></surname>
<given-names><![CDATA[G.M.]]></given-names>
</name>
<name>
<surname><![CDATA[de Souza]]></surname>
<given-names><![CDATA[C.M.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Chaves]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resina de Protium heptaphyllum: isolamento, caracterização estrutural e avaliação das propriedades térmicas]]></article-title>
<source><![CDATA[Quim. Nova]]></source>
<year>2005</year>
<volume>28</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>183-7</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Bruins]]></surname>
<given-names><![CDATA[A.P.]]></given-names>
</name>
<name>
<surname><![CDATA[Covey]]></surname>
<given-names><![CDATA[T.R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characterization of typical chemical background interferences in atmospheric pressure ionization liquid chromatographymass spectrometry]]></article-title>
<source><![CDATA[Rapid. Commun. Mass Spectrom]]></source>
<year>2006</year>
<volume>20</volume>
<numero>20</numero>
<issue>20</issue>
<page-range>3145-50</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hayasaka]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Analysis of phthalates in wine using liquid chromatography tandem mass spectrometry combined with a hold-back column: Chromatographic strategy to avoid the influence of pre-existing phthalate contamination in a liquid chromatography system]]></article-title>
<source><![CDATA[J. Chromatogr. A]]></source>
<year>2014</year>
<volume>1372</volume>
<page-range>120-7</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Ying]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Cao]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Pan]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Simultaneous determination of phthalates and parabens in cosmetic products by gas chromatography/mass spectrometry coupled with solid phase extraction (in Chinese)]]></article-title>
<source><![CDATA[Se Pu]]></source>
<year>2007</year>
<volume>25</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>272-5</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[M.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Hamerski]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Pinto]]></surname>
<given-names><![CDATA[A.C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Separação semipreparativa de a e (3-amirina por cromatografía líquida de alta eficiência]]></article-title>
<source><![CDATA[Quim. Nova]]></source>
<year>2011</year>
<volume>34</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>704-6</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barros]]></surname>
<given-names><![CDATA[F.W.A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bandeira]]></surname>
<given-names><![CDATA[P.N.]]></given-names>
</name>
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[D.J.B.]]></given-names>
</name>
<name>
<surname><![CDATA[Meira]]></surname>
<given-names><![CDATA[A.S.]]></given-names>
</name>
<name>
<surname><![CDATA[de Farias]]></surname>
<given-names><![CDATA[S.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Albuquerque]]></surname>
<given-names><![CDATA[M.R.J.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[H.S.D.]]></given-names>
</name>
<name>
<surname><![CDATA[Lemos]]></surname>
<given-names><![CDATA[T.L.G.]]></given-names>
</name>
<name>
<surname><![CDATA[de Morais]]></surname>
<given-names><![CDATA[M.O.]]></given-names>
</name>
<name>
<surname><![CDATA[Costa-Lotufo]]></surname>
<given-names><![CDATA[L.V.]]></given-names>
</name>
<name>
<surname><![CDATA[Pessoa]]></surname>
<given-names><![CDATA[C.D.O.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Amyrin esters induce cell death by apoptosis in HL-60 leukemia cells]]></article-title>
<source><![CDATA[Bioorg. Med. Chem]]></source>
<year>2011</year>
<volume>19</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1268-76</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
