<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182022000100293</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v51n1.95974</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Simultaneous determination of sulfamethoxazole, trimethoprim and bromhexine in veterinary formulation using high performance liquid chromatography (HPLC)]]></article-title>
<article-title xml:lang="pt"><![CDATA[Determinação simultânea de sulfametoxazol, trimetoprima e bromexina em formulação veterinária por cromatografia líquida de alta eficiência (HPLC)]]></article-title>
<article-title xml:lang="en"><![CDATA[Determinación simultánea de sulfametoxazol, trimetoprima y bromhexina en formulaciones veterinarias mediante cromatografía líquida de alta resolución (HPLC)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinosa dos Santos]]></surname>
<given-names><![CDATA[Patrícia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Serrou do Amaral]]></surname>
<given-names><![CDATA[Marcos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kassab]]></surname>
<given-names><![CDATA[Nájla Mohamad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Federal University of Mato Grosso do Sul  ]]></institution>
<addr-line><![CDATA[Campo Grande MS]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Neighborhood Universiy  ]]></institution>
<addr-line><![CDATA[Campo Grande MS]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>51</volume>
<numero>1</numero>
<fpage>293</fpage>
<lpage>315</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182022000100293&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182022000100293&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182022000100293&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo: desarrollar y validar un método simple, sensible y rápido para la determinación simultánea de sulfametoxazol (SMT), trimetoprima (TMP) y bromhexina (BMX) en formulación veterinaria por cromatografía líquida de alta resolución de acuerdo con las directrices de validación y control. Guía para la calidad analítica de medicamentos en productos alimenticios y medicamentos veterinarios, RDC 166/2017 y guías internacionales Conferencia Internacional sobre Armonización y Asociación Internacional de Químicos Analíticos Oficiales.  Materiales y métodos: la separación se realizó en una columna analítica ThermoScientific® C18 AcclaimTM120 (4,6 x 250 mm, 5 &#956;m), con caudal de 0,7 mL min-1 y detección a 245 nm, 265 nm y 271 nm, para BMX, SMT y TMP, respectivamente. Todas las mediciones se realizaron en metanol:agua (84:16 v/v; pH 3,0). Las curvas analíticas fueron lineales (r &gt; 0,9997) en el rango de concentración de 15.0 a 30.0 &#956;g-mL-1 para SMT, 3.0 a 9.0 &#956;g-mL-1 para TMP y 0,5 a 2,0 &#956;g-mL-1 para BMX.  Resultados: el método demostró ser preciso con coeficientes de variación por debajo del límite máximo de 2,0%, robusto, sin influencia significativa de las variaciones utilizadas en el análisis, exacto (recuperación &gt;99%) y selectivo, en la evaluación de la interferencia de adyuvantes  Conclusión: por lo tanto, el método desarrollado demostró ser adecuado para los análisis de control de calidad de rutina para la determinación simultánea de SMT, TMP y BMX en formulaciones farmacéuticas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY  Aim: To develop and to validate a simple, sensitive and fast method for the simultaneous determination of sulfamethoxazole (SMT), trimethoprim (TMP) and bromhexine (BMX) in veterinary formulation by high performance liquid chromatography according to the guidelines of the Validation and Control Guide for analytical quality of medicines in food products and veterinary medicines, RDC 166/2017 and international guides International Conference on Harmonization and International Association of Official Analytical Chemists.  Materials and methods: The separation was performed on a ThermoScientific® C18 AcclaimTM120 analytical column (4.6 X 250 mm, 5 &#956;m), with a flow rate of 0.7 mL min-1 and detection at 245 nm, 265 nm and 271 nm, for BMX, SMT and TMP, respectively. All measurements were performed in methanol: water (84:16 v/v; pH 3.0). The analytical curves were linear (r &gt; 0.9997) in the concentration range of 15.0 to 30.0 &#956;g-mL-1 for SMT, 3.0 to 9.0 &#956;g-mL-1 for TMP and 0.5 to 2.0 &#956;g-mL-1 for BMX.  Results: The method proved to be accurate, with coefficients of variation below the maximum limit of 2.0%, robust, without significant influence of the variations used in the analysis, exact (recovery &gt;99%) and selective, in the assessment of interference from adjuvants.  Conclusion:  Therefore, the developed method proved to be suitable for routine quality control analyzes for the simultaneous determination of SMT, TMP and BMX in pharmaceutical formulations.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Objetivo: desenvolver e validar um método simples, sensível e rápido para a determinação simultânea de sulfametoxazol (SMT), trimetoprima (TMP) e bromexina (BMX) em formulação veterinária por cromatografia líquida de alta eficiência de acordo com as diretrizes do Validation and Control Guia de qualidade analítica de medicamentos em produtos alimentícios e medicamentos veterinários, RDC 166/2017 e guias internacionais Conferência Internacional de Harmonização e Associação Internacional de Químicos Analíticos Oficiais.  Materiais e métodos: a separação foi realizada em coluna analítica ThermoScientific® C18 AcclaimTM120 (4,6 X 250 mm, 5 &#956;m), com vazão de 0,7 mL min-1 e detecção em 245 nm, 265 nm e 271 nm, para BMX , SMT e TMP, respectivamente. Todas as medições foram realizadas em metanol:água (84:16 v/v; pH 3,0). As curvas analíticas foram lineares (r &gt; 0,9997) na faixa de concentração de 15,0 a 30,0 &#956;g-mL-1 para SMT, 3,0 a 9,0 &#956;g-mL-1 para TMP e 0,5 a 2,0 &#956;g-mL-1 para BMX.  Resultados: o método mostrou-se preciso, com coeficientes de variação abaixo do limite máximo de 2,0%, robusto, sem influência significativa das variações utilizadas na análise, exato (recuperação &gt;99%) e seletivo, na avaliação da interferência de adjuvantes.  Conclusão: portanto, o método desenvolvido mostrou-se adequado para análises de controle de qualidade de rotina para a determinação simultânea de SMT, TMP e BMX em formulações farmacêuticas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Sulfamethoxazole]]></kwd>
<kwd lng="en"><![CDATA[trimethoprim]]></kwd>
<kwd lng="en"><![CDATA[bromhexine]]></kwd>
<kwd lng="en"><![CDATA[quality control]]></kwd>
<kwd lng="en"><![CDATA[analytical validation]]></kwd>
<kwd lng="pt"><![CDATA[Sulfametoxazol]]></kwd>
<kwd lng="pt"><![CDATA[trimetoprima]]></kwd>
<kwd lng="pt"><![CDATA[bromexina]]></kwd>
<kwd lng="pt"><![CDATA[controle de qualidade]]></kwd>
<kwd lng="pt"><![CDATA[validação analítica]]></kwd>
<kwd lng="es"><![CDATA[Sulfametoxazol]]></kwd>
<kwd lng="es"><![CDATA[trimetoprima]]></kwd>
<kwd lng="es"><![CDATA[bromhexina]]></kwd>
<kwd lng="es"><![CDATA[control de calidad]]></kwd>
<kwd lng="es"><![CDATA[validación analítica]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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