<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182022000200752</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v51n2.98279</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Biological activities of 1,4-naphthoquinones derivatives against T. cruzi and L. amazonensis]]></article-title>
<article-title xml:lang="es"><![CDATA[Actividades biológicas de derivados de 1,4-naftoquinonas contra T. cruzi y L. amazonensis]]></article-title>
<article-title xml:lang="pt"><![CDATA[Atividades biológicas de derivados de 1,4-naftoquinonas contra T. cruzi e L. amazonensis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[Adriano Olímpio da]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lopes]]></surname>
<given-names><![CDATA[Rosangela da Silva]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Naujorks]]></surname>
<given-names><![CDATA[Aline Alves dos Santos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[Celso Vataru]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[Dênis Pires de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal do Oeste do Pará  ]]></institution>
<addr-line><![CDATA[Juruti PA]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal de Mato Grosso do Sul  ]]></institution>
<addr-line><![CDATA[Campo Grande MS]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Estadual de Maringá  ]]></institution>
<addr-line><![CDATA[Maringá PR]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<volume>51</volume>
<numero>2</numero>
<fpage>752</fpage>
<lpage>786</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182022000200752&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182022000200752&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182022000200752&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY  Introduction: Chagas disease and Leishmaniasis are neglected diseases caused by the Trypanosoma cruzi and kentoplastid parasites Leishmania spp. Parasitic diseases cause great impact on social and economic, affecting millions of people in the world and represent a major global health problem. In the search for new alternatives for the treatment of Leishmaniasis and Chagas disease, strategies have been used to discover new active molecules, because there is an urgent need for the development of new drugs. In this scenario, 1,4-naphthoquinones have shown notable activity in the context of neglected diseases.  Aim: To synthesis of 1,4-naphthoquinones derivatives and evaluated these compounds against Trypanosoma cruzi epimastigotes, Leishmania promastigotes (Leishmania amazonensis) and cytotoxicity to LLCMK2 cells.  Results: Nine 1,4-naphthoquinones derivatives were synthesized using 2-Bromo-1,4-naphthoquinone (1), 1,4-Naphthoquinone (5) and 2-Hydroxi-1,4-naphthoqui-none (9) as starting material. Derivative 6a exhibited excellent trypanocidal activity, IC50 of 0.25 ± 0.02 µM, superior potency compared with the reference drug Benznidazol. Besides, these compounds displayed low activity against promastigote from L. amazonensis.  Conclusion: The results indicate that compound 6a may have potential for agent against Chagas disease.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La enfermedad de Chagas y la leishmaniasis son enfermedades desatendidas causadas por los parásitos Trypanosoma cruzi y kentoplastid Leishmania spp. Las enfermedades parasitarias tienen un gran impacto social y económico, afectan a millones de personas en el mundo y representan un importante problema de salud mundial. En la búsqueda de nuevas alternativas para el tratamiento de la leishmaniasis y la enfermedad de Chagas, se han utilizado estrategias para descubrir nuevas moléculas activas, porque existe una necesidad urgente de desarrollo de nuevos fármacos. En este escenario, las 1,4-naftoquinonas han mostrado una notable actividad en el contexto de enfermedades desatendidas.  Objetivo: Sintetizar derivados de 1,4-naftoquinonas y evaluación de estos compuestos frente a epimastigotes de Trypanosoma cruzi, promastigotes de Leishmania (Leishmania amazonensis) y citotoxicidad a células LLCMK2.  Resultados: Se sintetizaron nueve derivados de 1,4-naftoquinonas usando 2-bromo-1,4-naftoquinona (1), 1,4-naftoquinona (5) y 2-hidroxi-1,4-naftoquinona (9) como material de partida. El derivado 6a exhibió una excelente actividad tripanocida, CI50 de 0,25 ± 0,02 µM, potencia superior en comparación con el fármaco de referencia Benznidazol. Además, estos compuestos mostraron una baja actividad contra el promastigote de L. amazonensis.  Conclusión: Los resultados indican que el compuesto 6a puede tener potencial como agente contra la enfermedad de Chagas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução: A doença de Chagas e a leishmaniose são doenças negligenciadas causadas pelos parasitas Trypanosoma cruzi e kentoplastídeos Leishmania spp. As doenças parasitárias causam grande impacto social e econômico, afetando milhões de pessoas no mundo e representam um dos maiores problemas de saúde global. Na busca por novas alternativas para o tratamento da Leishmaniose e da doença de Chagas, estratégias têm sido utilizadas para descobrir novas moléculas ativas, porque há urgência no desenvolvimento de novos fármacos. Nesse cenário, as 1,4-nafto-quinonas têm mostrado notável atividade no contexto das doenças negligenciadas.  Objetivos: Sintetizar derivados de 1,4-naftoquinonas e avaliar esses compostos contra epimastigotas de Trypanosoma cruzi, promastigotas de Leishmania (Leishmania amazonensis) e citotoxicidade para células LLCMK2.  Resultados: Nove derivados de 1,4-naftoquinonas foram sintetizados usando 2-Bromo-1,4-naftoquinona (1), 1,4-Naftoquinona (5) e 2-Hidroxi-1,4-naftoquinona (9) como material de partida. O derivado 6a exibiu excelente atividade tripanocida, IC50 de 0,25 ± 0,02 µM, potência superior em comparação com o medicamento de referência Benzonidazol. Além disso, esses compostos apresentaram baixa atividade contra a forma promasti-gota de L. amazonensis.  Conclusão: Os resultados indicam que o composto 6a pode ter potencial para agente contra a doença de Chagas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Naphthoquinone]]></kwd>
<kwd lng="en"><![CDATA[Trypanosoma cruzi]]></kwd>
<kwd lng="en"><![CDATA[Leishmania]]></kwd>
<kwd lng="en"><![CDATA[Chagas diseases]]></kwd>
<kwd lng="es"><![CDATA[Naftoquinona]]></kwd>
<kwd lng="es"><![CDATA[Trypanosoma cruzi]]></kwd>
<kwd lng="es"><![CDATA[Leishmania]]></kwd>
<kwd lng="es"><![CDATA[enfermedad de Chagas]]></kwd>
<kwd lng="pt"><![CDATA[Naftoquinona]]></kwd>
<kwd lng="pt"><![CDATA[Trypanosoma cruzi]]></kwd>
<kwd lng="pt"><![CDATA[Leishmania]]></kwd>
<kwd lng="pt"><![CDATA[doença de Chagas]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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