<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182022000200860</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v51n2.98326</article-id>
<title-group>
<article-title xml:lang="pt"><![CDATA[Avaliação da citotoxicidade em hemácias de humanos do extrato etanólico de Praxelis clematidea (Griseb.)]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of Cytotoxicity in human red blood cells of Praxelis clematidea (Griseb.) ethanol extract]]></article-title>
<article-title xml:lang="es"><![CDATA[Evaluación de la citotoxicidad en glóbulos rojos humanos del extracto etanólico de Praxelis clematidea (Griseb.)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres Pereira]]></surname>
<given-names><![CDATA[Maria Estella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres Pereira]]></surname>
<given-names><![CDATA[Camilla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soares Medeiros]]></surname>
<given-names><![CDATA[Cássio Ilan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barbosa-Filho]]></surname>
<given-names><![CDATA[José Maria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maia]]></surname>
<given-names><![CDATA[Gabriela Lemos de Azevedo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[Aleson Pereira de]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Filho]]></surname>
<given-names><![CDATA[Abrahão Alves de Oliveira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal de Campina Grande  ]]></institution>
<addr-line><![CDATA[Patos ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal da Paraíba  ]]></institution>
<addr-line><![CDATA[João Pessoa ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal do Vale do São Francisco  ]]></institution>
<addr-line><![CDATA[Petrolina ]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Federal da Paraíba  ]]></institution>
<addr-line><![CDATA[João Pessoa ]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2022</year>
</pub-date>
<volume>51</volume>
<numero>2</numero>
<fpage>860</fpage>
<lpage>870</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182022000200860&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182022000200860&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182022000200860&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução: Espécies da família Asteraceae são conhecidas por apresentarem propriedades aromática, cosmética e terapêutica; tendo diversas pesquisas que evidenciou potencial medicinal dessa família. Dentre as espécies de Asteraceae, está Praxelis clematidea, que é rica em substâncias químicas como flavonoides, terpenóides e esteroides, as quais podem desempenhar uma série de atividades biológicas.  Objetivo: Verificar o potencial tóxico do extrato etanólico das folhas de P. clematidea frente à células sanguíneas humanas, afim de determinar a toxicidade teórica dessa espécie.  Métodos: Para a realização do teste de atividade citotóxica foram preparadas suspensões sanguíneas dos tipos A, B e O, que posteriormente foram misturadas a concentrações distintas do extrato etanólico por 1 (uma) hora. A hemólise foi quantificada por espectrofotometria em comprimento de onda de 540 nm.  Resultados: O extrato etanólico das folhas de P. clematidea em diferentes concentrações apresentou baixa citoxicidade contra os eritrócitos humanos in vitro, enfatizando o produto como uma possível opção viável para a indústria de medicamentos fitoterápicos. No entanto, é importante elucidar que mais estudos in vivo precisam ser realizados para confirmar esse perfil toxicológico do extrato.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[SUMMARY  Introduction: Species of the Asteraceae family are known to have aromatic, cosmetic and therapeutic properties; having several researches that evidenced medicinal potential of this family. Among the species of Asteraceae, there is Praxelis clematidea, which is rich in chemical substances such as flavonoids, terpenoids and steroids, which can perform a series of biological activities.  Aim: To verify the toxic potential of the ethanolic extract of P. clematidea leaves against human blood cells, in order to determine the theoretical toxicity of this species.  Method: For the performance of the cytotoxic activity test, blood suspensions of types A, B and O were prepared, which were subsequently mixed at different concentrations of the ethanolic extract for 1 (one) hour. Hemolysis was quantified by spectrophotometry at a wavelength of 540 nm.  Results: The ethanolic extract of P. clematidea leaves in different concentrations showed low cytotoxicity against human erythrocytes in vitro, emphasizing the product as a possible viable option for the herbal medicine industry. However, it is important to clarify that more in vivo studies need to be carried out to confirm this toxicological profile of the extract.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: Se sabe que las especies de la familia Asteraceae tienen propiedades aromáticas, cosméticas y terapéuticas; habiendo varias investigaciones que evidenciaron el potencial medicinal de esta familia. Entre las especies de Asteraceae, se encuentra Praxelis clematidea, que es rica en sustancias químicas como flavonoides, terpenoides y esteroides, que pueden realizar una serie de actividades biológicas.  Objetivo: Verificar el potencial tóxico del extracto etanólico de hojas de P. clematidea contra las células sanguíneas humanas, con el fin de determinar la toxicidad teórica de esta especie.  Metodos: Para realizar la prueba de actividad citotóxica se prepararon suspensiones de sangre de los tipos A, B y O, que luego se mezclaron a diferentes concentraciones del extracto etanólico durante 1 (una) hora. La hemólisis se cuantificó mediante espectrofotometría a una longitud de onda de 540 nm.  Resultados: El extracto etanólico de hojas de P. clematidea a diferentes concentraciones mostró baja citotoxicidad contra eritrocitos humanos in vitro, destacando el producto como una posible opción viable para la industria de la fitoterapia. Sin embargo, es importante aclarar que es necesario realizar más estudios in vivo para confirmar este perfil toxicológico del extracto.]]></p></abstract>
<kwd-group>
<kwd lng="pt"><![CDATA[Citotoxicidade]]></kwd>
<kwd lng="pt"><![CDATA[eritrócitos]]></kwd>
<kwd lng="pt"><![CDATA[Praxelis clematidea]]></kwd>
<kwd lng="en"><![CDATA[Cytotoxicity]]></kwd>
<kwd lng="en"><![CDATA[Erythrocytes]]></kwd>
<kwd lng="en"><![CDATA[Praxelis clematidea]]></kwd>
<kwd lng="es"><![CDATA[Citotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[eritrocitos]]></kwd>
<kwd lng="es"><![CDATA[Praxelis clematidea]]></kwd>
</kwd-group>
</article-meta>
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