<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7418</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Químico - Farmacéuticas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. colomb. cienc. quim. farm.]]></abbrev-journal-title>
<issn>0034-7418</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74182023000200640</article-id>
<article-id pub-id-type="doi">10.15446/rcciquifa.v52n2.110730</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Development and characterization of doxycycline gelatin nanoparticles]]></article-title>
<article-title xml:lang="es"><![CDATA[Desarrollo y caracterización de nanopartículas de gelatina de doxiciclina]]></article-title>
<article-title xml:lang="pt"><![CDATA[Desenvolvimento e caracterização de nanopartículas de gelatina de doxiciclina]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Guzmán]]></surname>
<given-names><![CDATA[Perla]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ocampo]]></surname>
<given-names><![CDATA[Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutierrez]]></surname>
<given-names><![CDATA[Lilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sumano]]></surname>
<given-names><![CDATA[Hector]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernad]]></surname>
<given-names><![CDATA[María Josefa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2023</year>
</pub-date>
<volume>52</volume>
<numero>2</numero>
<fpage>640</fpage>
<lpage>657</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74182023000200640&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74182023000200640&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74182023000200640&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ Introduction Introduction: Doxycycline (DOXI) is a wide-spectrum antimicrobial drug used for urinary, intestinal, respiratory, ocular, dental, dermatological, and sexually transmitted infections. The development of drug delivery systems based on carriers like nanoparticles (NP) allow to overcome limitations like instability in biological environment, bacterial resistance, and poor cellular penetration. Also, cationic nanocarriers may allow interaction with bacterial membranes or mucus layers to improve the bactericidal action.  Aim Aim: To develop and to characterize a drug delivery system for DOXI based on cationic gelatin nanoparticles, intended to mucus delivery for antibacterial therapy.  Materials and methods Materials and methods: Gelatin nanoparticles were prepared using the desolvation method, where the effect of stirring speed, concentration of Pluronic F-68, gelatin and volume of crosslinking agent were investigated. The system was characterized by particle size, zeta potential, FT-IR, SEM, Entrapment efficiency and mathematical modeling of in vitro profile release.  Results and discussion Results and discussion: A stable nanoparticle dispersion (~200 nm, PDI&gt;0.3) was obtained with high entrapment efficiency (~60%) and cationic surface properties, with prolonged release for 8 h.  Conclusions Conclusions: The process factors and formulation studied successfully lead a doxycycline loaded cationic gelatin nanoparticles with desirable characteristics. The NP showed prolonged release for 8 hours with an anomalous transport as main mechanism of drug delivery. The system prepared own cationic surface properties to be a possible mucoadhesive system.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[ Introducción Introducción: la doxiciclina (DOXI) es un fármaco antimicrobiano de amplio espectro utilizado para infecciones urinarias, intestinales, respiratorias, oculares, dentales, dermatológicas y de transmisión sexual. El desarrollo de sistemas de administración de fármacos basados en acarreadores como las nanopartículas (NP), permiten superar limitaciones como la inestabilidad en el entorno biológico, la resistencia bacteriana y la mala penetración celular. Además, los nanoacarreadores catiónicos pueden permitir la interacción con membranas bacterianas o mucosas para mejorar la acción bactericida.  Objetivo Objetivo: desarrollar y caracterizar un sistema de administración de fármacos para DOXI basado en nanopartículas catiónicas de gelatina, destinado a la administración en mucosas para terapia antibacteriana.  Materiales y métodos Materiales y métodos: se prepararon nanopartículas de gelatina utilizando el método de desolvatación, donde se investigó el efecto de la velocidad de agitación, la concentración de Pluronic F-68, la gelatina y el volumen del agente de entrecruzamiento. El sistema se caracterizó por el tamaño de partícula, potencial zeta, FT-IR, SEM, eficiencia de entrampe y modelado matemático del perfile de liberación in vitro.  Resultados y discusión Resultados y discusión: se obtuvo una dispersión estable de nanopartículas (~200 nm, PDI&gt;0,3) con alta eficiencia de entrampe (~60%), propiedades superficiales catiónicas, y liberación prolongada durante 8 h.  Conclusiones Conclusiones: los factores de proceso y la formulación estudiados permitieron obtener nanopartículas catiónicas de gelatina cargadas con DOXI con características deseables. Las NP mostraron liberación prolongada durante 8 horas con un transporte anómalo como principal mecanismo de liberación de fármaco. El sistema preparado presentó propiedades superficiales catiónicas adecuadas para ser un posible sistema mucoadhesivo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[ Introdução Introdução: a doxiciclina (DOXI) é um antimicrobiano de amplo espectro utilizado para infecções urinárias, intestinais, respiratórias, oculares, dentárias, dermatológicas e sexualmente transmissíveis. O desenvolvimento de sistemas de liberação de fármacos baseados em carreadores como as nanopartículas (NPs) permite superar limitações como instabilidade no ambiente biológico, resistência bacteriana e baixa penetração celular. Além disso, os nanocarreadores catiônicos podem permitir a interação com membranas bacterianas ou mucosas para aumentar a ação bactericida.  Objetivo Objetivo: desenvolver e caracterizar de um sistema de liberação de fármacos para DOXI baseado em nanopartículas catiônicas de gelatina, destinado à liberação mucosa para terapia antibacteriana.  Materiais e métodos Materiais e métodos: as nanopartículas de gelatina foram preparadas usando o método de dessolvatação, onde o efeito da velocidade de agitação, concentração de Pluronic F-68, gelatina e volume do agente de reticulação foram investigados. O sistema foi caracterizado por tamanho de partícula, potencial zeta, FT-IR, SEM, eficiência de captura e modelagem matemática do perfil de liberação in vitro.  Resultados e discussão Resultados e discussão: obteve-se uma dispersão estável de nanopartículas (~200 nm, PDI&gt;0,3) com alta eficiência de captura (~60%), propriedades de superfície catiônica e liberação prolongada por 8 h.  Conclusões Conclusões: os fatores de processo e formulação estudados permitiram a obtenção de nanopartículas de gelatina catiônica carregada com DOXI com características desejáveis. As NPs apresentaram liberação prolongada por 8 horas com transporte anormal como principal mecanismo de liberação do fármaco. O sistema preparado apresentou propriedades de superfície catiônica adequadas para ser um possível sistema mucoadesivo.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Doxycycline]]></kwd>
<kwd lng="en"><![CDATA[gelatin]]></kwd>
<kwd lng="en"><![CDATA[nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[modified release]]></kwd>
<kwd lng="es"><![CDATA[Doxiciclina]]></kwd>
<kwd lng="es"><![CDATA[gelatina]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas]]></kwd>
<kwd lng="es"><![CDATA[liberación modificada]]></kwd>
<kwd lng="pt"><![CDATA[Doxiciclina]]></kwd>
<kwd lng="pt"><![CDATA[gelatina]]></kwd>
<kwd lng="pt"><![CDATA[nanopartículas]]></kwd>
<kwd lng="pt"><![CDATA[liberação modificada]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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