<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7450</journal-id>
<journal-title><![CDATA[Revista Colombiana de Psiquiatría]]></journal-title>
<abbrev-journal-title><![CDATA[rev.colomb.psiquiatr.]]></abbrev-journal-title>
<issn>0034-7450</issn>
<publisher>
<publisher-name><![CDATA[Asociacion Colombiana de Psiquiatria.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-74502020000100062</article-id>
<article-id pub-id-type="doi">10.1016/j.rcp.2018.05.002</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Deep-brain stimulation in treatment-resistant obsessive-compulsive disorder: Clinical and molecular neuroimaging correlation]]></article-title>
<article-title xml:lang="es"><![CDATA[Estimulación cerebral profunda en el trastorno obsesivo compulsivo resistente a tratamiento: correlato clínico y de neuroimagen molecular]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Onate-Cadena]]></surname>
<given-names><![CDATA[Nelcy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cisneros-Otero]]></surname>
<given-names><![CDATA[Marcela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Chow]]></surname>
<given-names><![CDATA[Ángel Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arellano-Reynoso]]></surname>
<given-names><![CDATA[Alfonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kobayashi-Romero]]></surname>
<given-names><![CDATA[Luis Fabian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Esparza]]></surname>
<given-names><![CDATA[Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Departamento de Neuropsiquiatría ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Departamento de Neurocirugía, Programa de Neurocirugía Funcional ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Laboratorio de Investigación en Adicciones ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>49</volume>
<numero>1</numero>
<fpage>62</fpage>
<lpage>65</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0034-74502020000100062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0034-74502020000100062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0034-74502020000100062&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Obsessive-compulsive disorder is defined by the presence of obsessions and compulsions that cause marked anxiety or distress and has been associated with a disruption in corticostriato-thalamo-cortical circuitry. After treatment, around 50% of patients continue to experience incapacitating symptoms. Deep-brain stimulation has been shown to be an effective therapeutic alternative to regular treatment.  Methods:  Case report.  Case presentation:  A 54-year-old woman with a diagnosis of treatment-resistant obsessive-compulsive disorder was treated with deep-brain stimulation of the anterior limb of the internal capsule. Molecular imaging before and after the procedure was obtained and correlated with clinical features.  Conclusions:  Deep-brain stimulation may be a therapeutic alternative to regular care in treatment-resistant obsessive-compulsive disorder and can be correlated to functional changes in suspected anatomical structures.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El trastorno obsesivo-compulsivo se define por la presencia de obsesiones y compulsiones que ocasionan ansiedad y malestar marcados, y se ha asociado con una alteración en los circuitos cortico-estriado-tálamo-corticales. Tras tratamiento, alrededor de la mitad de los pacientes permanecen con síntomas discapacitantes. La estimulación cerebral profunda ha mostrado ser una alternativa efectiva al tratamiento usual.  Métodos:  Reporte de caso.   Presentación del caso:  Una mujer de 54 años con diagnóstico de trastorno obsesivo-compulsivo resistente a tratamiento fue tratada con estimulación cerebral profunda del brazo anterior de la cápsula interna. Se obtuvieron imágenes moleculares antes y después de la intervención y fueron correlacionadas con el cuadro clínico.  Conclusiones:  La estimulación magnética profunda puede ser una alternativa terapéutica al tratamiento usual en el trastorno obsesivo compulsivo resistente a tratamiento, y puede correlacionarse con cambios funcionales en estructuras anatómicas de sospecha.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Obsessive-compulsive disorder Deep-brain stimulation Treatment-resistant Molecular imaging]]></kwd>
<kwd lng="es"><![CDATA[Trastorno obsesivo-compulsivo]]></kwd>
<kwd lng="es"><![CDATA[Estimulación cerebral profunda]]></kwd>
<kwd lng="es"><![CDATA[Resistente a tratamiento]]></kwd>
<kwd lng="es"><![CDATA[Imagen molecular]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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