0034-7450 0034-7450 S0034-74502021000200070 10.1016/j.rcp.2020.01.005 España 00 06 2021 00 06 2021 50 2 70 71 1 2017 14 2 2015 44 405-18 3 2017 207 251-9 4 2017 29 207-13 5 2018 15 12 12