<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112010000300007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[MECANISMOS CELULARES EN RESPUESTA AL ESTRÉS:: SIRTUINAS]]></article-title>
<article-title xml:lang="en"><![CDATA[Cellular mechanisms in response to stress: sirtuin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Echeverri-Ruíz]]></surname>
<given-names><![CDATA[Nancy Paola]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mockus-Sivickas]]></surname>
<given-names><![CDATA[Ismena]]></given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Miami Univerasity Departamento de Zoología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="A02">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>07</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>07</month>
<year>2010</year>
</pub-date>
<volume>58</volume>
<numero>3</numero>
<fpage>221</fpage>
<lpage>232</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112010000300007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112010000300007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112010000300007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Desde hace algún tiempo se conoce el papel de la restricción calórica sobre la longevidad y la prevención de enfermedades crónicas, pero hasta hace poco los mecanismos celulares involucrados comienzan a ser elucidados. El estrés celular se podría definir como el estado en el que la célula no presenta las condiciones óptimas de supervivencia, siendo el oxidativo un tipo de estrés en el que se generan radicales libres nocivos para las estructuras celulares. La restricción calórica podría incrementar la resistencia celular a diferentes formas de estrés. Las sirtuinas, proteínas deacetilasas de histonas tipo III, están involucradas en la relación entre balance energético y transcripción génica, permitiendo que la célula responda a la restricción calórica y sobreviva a situaciones de estrés oxidativo. En esta relación las sirtuinas regulan genes de la familia FOXO, cMYC, hTERT, p53, entre otros. La activación o silenciamiento de estos genes es importante en los procesos de apoptosis, reparación y muerte celular.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[The role of caloric restriction on longevity and prevention of chronic diseases has been known for some time; recently, cellular mechanisms involved are beginning to be elucidated. Cellular stress could be defined as the state in which the cell does not present optimal survival conditions; oxidative stress is a type of stress in which free radicals harmful cell structures. Caloric restriction might increase cellular resistance to various forms of stress. Sirtuins, histone deacetylases type III proteins are involved in the relationship between energy balance and gene transcription, allowing cell to respond to caloric restriction and to survive to oxidative stress. In this relationship, sirtuins regulate FOXO family genes, cMYC, hTERT, p53, among others. Activation or silencing of those genes is important in the process of apoptosis, repair and cell death]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[abastecimiento de energía]]></kwd>
<kwd lng="es"><![CDATA[restricción calórica]]></kwd>
<kwd lng="es"><![CDATA[senescencia]]></kwd>
<kwd lng="es"><![CDATA[longevidad]]></kwd>
<kwd lng="es"><![CDATA[sirtuinas]]></kwd>
<kwd lng="es"><![CDATA[telómero]]></kwd>
<kwd lng="es"><![CDATA[telomerasa]]></kwd>
<kwd lng="en"><![CDATA[energy supply]]></kwd>
<kwd lng="en"><![CDATA[caloric restriction]]></kwd>
<kwd lng="en"><![CDATA[aging]]></kwd>
<kwd lng="en"><![CDATA[longevity]]></kwd>
<kwd lng="en"><![CDATA[sirtuins]]></kwd>
<kwd lng="en"><![CDATA[telomere]]></kwd>
<kwd lng="en"><![CDATA[telomerase]]></kwd>
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