<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112017000300501</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v65n3.52835</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Potential pharmacological use of salivary compounds from hematophagous organisms]]></article-title>
<article-title xml:lang="es"><![CDATA[Uso potencial farmacológico de los compuestos salivares de organismos hematófagos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velásquez]]></surname>
<given-names><![CDATA[Juan José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Navarro-Vargas]]></surname>
<given-names><![CDATA[José Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moncada]]></surname>
<given-names><![CDATA[Ligia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Faculty of Medicine Department of Surgery]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Colombia Faculty of Medicine Department of Public Health]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2017</year>
</pub-date>
<volume>65</volume>
<numero>3</numero>
<fpage>501</fpage>
<lpage>505</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112017000300501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112017000300501&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112017000300501&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The saliva of hematophagous or blood-sucking insects contains different substances that allow obtaining and ingesting the blood of their vertebrate hosts without being detected.  Objective: To explore the salivary compounds of hematophagous insects which have vasodilator, anticoagulant, anti-inflammatory, immunomodulatory and anesthetic properties, and that can be exploited due to their high pharmacological potential.  Materials and methods: A non-systematic literature review was done in PubMed, EMBASE, and ScienceDirect OvidSP; data was not limited by date, language nor item type. Articles on salivary compounds of blood-sucking insects, whose main topic was the effects on hemostasis, immunomodulation and drug use, were sought. 59 articles met the criteria for inclusion in the review.  Conclusions: The saliva of hematophagous insects has a wide variety of molecules that constitute a source of research and have an incalculable potential for the discovery of compounds that could be pharmacologically useful.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. La saliva de los artrópodos hematófagos contiene un arsenal de compuestos que les permite acceder a la sangre de sus hospederos vertebrados sin ser detectados.  Objetivo. Explorar los compuestos salivares de insectos hematófagos que tienen propiedades vasodilatadoras, anticoagulantes, antiinflamatorias, inmunomoduladoras y anestésicas, las cuales se pueden aprovechar por su alto potencial farmacológico.  Materiales y métodos. Se realizó una revisión no sistemática de la literatura mediante búsqueda electrónica en las bases de datos PubMed, EMBASE, OvidSP y ScienceDirect; la búsqueda no se limitó por fecha, idioma ni tipo de artículo. Se buscaron artículos sobre los compuestos salivares de los insectos hematófagos, cuyo tema central fuese los efectos en la hemostasia, inmunomodulación y uso farmacológico. Se encontraron 59 artículos que cumplían con los criterios para ser incluidos en la revisión.  Conclusión. La saliva de los insectos hematófagos posee gran variedad de moléculas, lo que ofrece una fuente de investigación y un potencial incalculable para el descubrimiento de compuestos que podrían llegar a tener utilidad farmacológica.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Saliva]]></kwd>
<kwd lng="en"><![CDATA[Pharmacology]]></kwd>
<kwd lng="en"><![CDATA[Anticoagulants]]></kwd>
<kwd lng="en"><![CDATA[Vasodilators]]></kwd>
<kwd lng="en"><![CDATA[Anti-inflammatory]]></kwd>
<kwd lng="en"><![CDATA[Anesthetics (MeSH)]]></kwd>
<kwd lng="es"><![CDATA[Saliva]]></kwd>
<kwd lng="es"><![CDATA[Farmacología]]></kwd>
<kwd lng="es"><![CDATA[Anticoagulantes]]></kwd>
<kwd lng="es"><![CDATA[Vasodilatadores]]></kwd>
<kwd lng="es"><![CDATA[Antiinflamatorios]]></kwd>
<kwd lng="es"><![CDATA[Anestésicos (DeCS)]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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