<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112017000400627</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v65n4.59769</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Enfermedad renal crónica y sangrado entre pacientes bajo profilaxis con heparinas de bajo peso molecular]]></article-title>
<article-title xml:lang="en"><![CDATA[Chronic kidney disease and bleeding in patients under low molecular weight heparin prophylaxis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espinosa-Almanza]]></surname>
<given-names><![CDATA[Carmelo José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaitán-Duarte]]></surname>
<given-names><![CDATA[Hernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Medicina Instituto de Investigaciones Clínicas]]></institution>
<addr-line><![CDATA[Bogotá D.C ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Clínica San Rafael Departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[Bogotá D.C ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>65</volume>
<numero>4</numero>
<fpage>627</fpage>
<lpage>631</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112017000400627&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112017000400627&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112017000400627&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. La seguridad del uso profiláctico de heparinas de bajo peso molecular (HBPM) en pacientes con función renal alterada continúa no definida.  Objetivo. Establecer si la reducción de la tasa de filtración glomerular (TFG) se asocia al desarrollo de sangrado bajo profilaxis con HBPM.  Materiales y métodos. Se construyó una cohorte de pacientes no quirúrgicos en profilaxis con HBPM sobre la cual se anidó un estudio de casos y controles. Fue posible obtener del seguimiento los casos de sangrado y se tomaron cuatro controles sobre la población a riesgo al tiempo de aparición de cada caso.  Resultados. De 716 pacientes en seguimiento, se presentaron 51 sangrados con una incidencia de 3 casos por 100 pacientes por día en tratamiento; el 39% de los casos fueron mayores y se tomaron 204 controles. El análisis multivariado no mostró relación entre sangrado y la anormalidad de la función renal por reducción de la TFG. Sin embargo, solo el 3.5% de pacientes tuvo una TFG&lt;30ml/min. El Odds Ratio (OR) final ajustado fue 1.27 y el intervalo de confianza (IC) al 95% fue 0.60-2.68.  Conclusiones. No se encontró relación entre la reducción de la TFG leve a moderada y el desarrollo de sangrado bajo profilaxis con HBPM.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The safety of low molecular weight heparin (LMWH) prophylaxis in patients with impaired kidney function remains undefined.  Objective: To establish if the reduction of the glomerular filtration rate (GFR) is associated with the development of bleeding under LMWH prophylaxis.  Materials and methods: A cohort of non-surgical patients with LMWH prophylaxis was constructed in order to conduct a case-control study. Monitoring allowed to find bleeding cases, while four controls were chosen from the population at risk at the time of bleeding onset.  Results: Out of 716 monitored patients, 51 presented with bleeding, with an incidence of 3 cases per 100 patients per day of treatment; 39% of the cases presented with major bleeding and 204 controls were chosen. The multivariate analysis showed no relationship between bleeding and abnormal renal function due to GFR reduction. However, only 3.5% ofpatients had GFR &lt;30ml/min. The final adjusted odds ratio (OR) was 1.27 and the 95% confidence interval (CI) was 0.60-2.68.  Conclusion: No correlation was found between the reduction of mild to moderate GFR and the development of bleeding under LMWH prophylaxis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Trombosis de la vena]]></kwd>
<kwd lng="es"><![CDATA[Enoxaparina]]></kwd>
<kwd lng="es"><![CDATA[Embolia pulmonar]]></kwd>
<kwd lng="es"><![CDATA[Insuficiencia renal crónica (DeCS)]]></kwd>
<kwd lng="en"><![CDATA[Deep Venous Thrombosis]]></kwd>
<kwd lng="en"><![CDATA[Enoxaparin]]></kwd>
<kwd lng="en"><![CDATA[Pulmonary Embolism (MeSH)]]></kwd>
</kwd-group>
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