<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112019000100165</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v67n1.62826</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Metástasis cerebral de melanoma lentiginoso acral]]></article-title>
<article-title xml:lang="en"><![CDATA[Brain metastasis of acral lentiginous melanoma. Case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Méndez-Mathey]]></surname>
<given-names><![CDATA[Vanessa Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Privada San Juan Bautista Facultad de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>67</volume>
<numero>1</numero>
<fpage>165</fpage>
<lpage>168</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112019000100165&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112019000100165&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112019000100165&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. El melanoma lentiginoso acral es un subtipo de melanoma potencialmente agresivo y el tercer tumor primario en producir metástasis cerebral. Debuta con síntomas neurológicos y hemorragia intracerebral en el 50% de los casos y afecta las palmas de las manos, las plantas de los pies y las regiones subungueales. Su pronóstico es pobre en comparación con otras variantes clínicas debido a que estos melanomas son diagnosticados de forma tardía. Representan el 4% de todas las neoplasias malignas de la piel y son responsables del 80% de las muertes.  Presentación del caso. Paciente masculino de 44 años de edad, foto tipo cutáneo tipo IV, que presenta lesión en planta de pie izquierdo, pigmentada y ulcerada, de crecimiento lento con cerca de 2 años de evolución. El sujeto fue sometido a intervención quirúrgica para resección de melanoma lentiginoso acral 1 año atrás e ingresó a emergencias por presentar cuadro neurológico súbito y compromiso de conciencia. Se realizó tomografía axial computarizada cerebral donde se observó tumoración temporoparietal izquierda hiperdensa de 4.1x5cm con edema perilesional y hemorragia. Previa estabilización, el hombre fue referido a un centro hospitalario de mayor nivel para tratamiento microquirúrgico.  Conclusiones. Dado que el melanoma metastásico es una enfermedad incurable, el diagnostico precoz y oportuno de lesiones dérmicas accesibles a la inspección para iniciar tratamiento es prioritario para mejorar el pronóstico de esta enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Acral lentiginous melanoma is a subtype of potentially aggressive melanoma and the third primary tumor to cause brain metastases. It debuts with neurological symptoms and intracerebral hemorrhage in 50% of the cases, and affects the palms of the hands, the soles of the feet and the subungual regions. Its prognosis is poor compared to other clinical variants because these melanomas are diagnosed late. They account for 4% of all malignant skin neoplasms and are responsible for 80% of deaths.  Case presentation: 44-year-old male patient, skin phototype IV, who had a lesion on the left foot sole, pigmented and ulcerated, of slow growth, with about 2 years of evolution. The subject underwent surgery for resection of acral lentiginous melanoma 1 year before consultation and was admitted to the emergency department due to sudden neurological symptoms and compromised consciousness. Computed tomography scan of the brain was performed, showing a hyperdense temporoparietal left tumor of 4.1x5cm with perilesional edema and hemorrhage. After stabilization, the patient was referred to a higher level hospital for microsurgical treatment.  Conclusions: Since metastatic melanomas are incurable, early and timely diagnosis of dermal lesions accessible for inspection to initiate treatment is a priority to improve the prognosis of this disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Neoplasias cutáneas]]></kwd>
<kwd lng="es"><![CDATA[Melanoma]]></kwd>
<kwd lng="es"><![CDATA[Metástasis]]></kwd>
<kwd lng="es"><![CDATA[Nevo pigmentado (DeSC)]]></kwd>
<kwd lng="en"><![CDATA[Skin Neoplasms]]></kwd>
<kwd lng="en"><![CDATA[Melanoma]]></kwd>
<kwd lng="en"><![CDATA[Metastasis]]></kwd>
<kwd lng="en"><![CDATA[Nevus, Pigmented (MeSH)]]></kwd>
</kwd-group>
</article-meta>
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