<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112020000200279</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v68n2.74440</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El periodo refractario de las células excitables: ¿inconsistencias de un dogma?]]></article-title>
<article-title xml:lang="en"><![CDATA[The refractory period of excitable cells: Inconsistencies of a dogma?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barco-Ríos]]></surname>
<given-names><![CDATA[John]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duque-Parra]]></surname>
<given-names><![CDATA[Jorge Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barco-Cano]]></surname>
<given-names><![CDATA[Johanna Alexandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Caldas Facultad de Ciencias para la Salud Departamento de Ciencias Básicas para la Salud]]></institution>
<addr-line><![CDATA[Manizales ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Caldas Facultad de Ciencias para la Salud Grupo Neurociencia de Caldas]]></institution>
<addr-line><![CDATA[Manizales ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Manizales Facultad de Ciencias para la Salud Departamento de Ciencias Básicas para la Salud]]></institution>
<addr-line><![CDATA[Manizales ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Caldas Facultad de Ciencias para la Salud Departamento Clínico]]></institution>
<addr-line><![CDATA[Manizales ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>68</volume>
<numero>2</numero>
<fpage>279</fpage>
<lpage>282</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112020000200279&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112020000200279&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112020000200279&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. Los canales activados por voltaje para Na+ y para K+ presentan compuertas de activación e inactivación, las cuales se abren y se cierran dependiendo de la intensidad de la corriente eléctrica que fluye por la membrana cuando está respondiendo a un estímulo. Durante este breve momento, la membrana entra en un periodo de refractariedad que la hace insensible a otros estímulos.  Objetivo. Demostrar que los periodos refractarios absoluto y relativo se presentan a medida que se va desarrollando el potencial de acción y no después de que se ha completado, mediante un análisis teórico basado en el funcionamiento eléctrico normal de los canales activados por voltaje para Na+ y K+.  Cuestionamientos.  En diversos textos y artículos de fisiología, las definiciones de los periodos refractarios absoluto y relativo son confusas y erróneas, puesto que no tienen en cuenta el funcionamiento normal de los canales activados por voltaje. Además, la ubicación que dan a dichos periodos con respecto al potencial de acción es desfasada y su tiempo de duración es incierto.  Conclusión.  Los periodos refractarios absoluto y relativo se presentan durante el desarrollo del potencial de acción y no después de que ha sido completado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Voltage-gated Na+ and K+ channels have activation and inactivation gates that open and close depending on the intensity of the electric current flowing through the membrane when it is responding to a stimulus. During this brief moment, the membrane enters a refractory period that makes it insensitive to other stimuli.  Objective: To prove that absolute and relative refractory periods occur as the action potential develops rather than after it has been completed, by means of a theoretical analysis based on the normal electrical functioning of voltage-gated Na+ and K+ channels.  Questioning: Several texts and articles on physiology provide confusing and misleading definitions of absolute and relative refractory periods, since they don't consider the normal functioning of voltage-gated channels. Furthermore, the location they give to these periods in relation to the action potential is out-of-time and their duration remains uncertain.  Conclusion: Absolute and relative refractory periods occur as the action potential develops rather than after it has been completed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Potenciales de acción]]></kwd>
<kwd lng="es"><![CDATA[Canales iónicos]]></kwd>
<kwd lng="es"><![CDATA[Fisiología (DeCS)]]></kwd>
<kwd lng="en"><![CDATA[Action Potentials]]></kwd>
<kwd lng="en"><![CDATA[Ion Channels]]></kwd>
<kwd lng="en"><![CDATA[Physiology (MeSH)]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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