<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112021000400200</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v69n4.79817</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Symptom variability in outpatients with COPD and validation of the Colombian COPD Symptom Variability Instrument (EPOC-CoVaSy)]]></article-title>
<article-title xml:lang="es"><![CDATA[Variabilidad de síntomas en pacientes ambulatorios con EPOC y validación del Instrumento Colombiano de Variabilidad de Síntomas en EPOC (EPOC-CoVaSy)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Mejía]]></surname>
<given-names><![CDATA[Eidelman Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Uñate-Suárez]]></surname>
<given-names><![CDATA[Olga Constanza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bula-Gutiérrez]]></surname>
<given-names><![CDATA[Carlos José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Patino-Jiménez]]></surname>
<given-names><![CDATA[Yojana Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro de Atención Pulmonar C.A.P  ]]></institution>
<addr-line><![CDATA[Barranquilla ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Clinical and Epidemiological Research (CER)  ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>69</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112021000400200&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112021000400200&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112021000400200&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The variability of respiratory symptoms in chronic obstructive pulmonary disease (COPD) is considered to be low or nonexistent. However, some authors state that there may be fluctuations.  Objectives: To describe symptom variability in patients with COPD throughout the day and night for four weeks using a patient diary, and to validate a questionnaire created for such purpose (Colombian Self-Ad -ministered Instrument of Symptom Variability in COPD - EPOC-CoVaSy).  Materials and methods: Cohort study conducted in 96 patients with COPD treated between June and December 2016 at the Centro de Atención Pulmonar - CAP in Barranquilla, Colombia, who filled out a patient diary for four weeks and, after this period, the self-administered EPOC-CoVaSy instrument. Independence and comparison of frequencies of categorical and continuous variables were established using the chi- square and the Fisher ' s exact tests and the Pearson's correlation coefficient, respectively. A MANO-VA was performed using linear regression models to determine the correlations between the results of the diary and the instrument.  Results: Participants' mean age was 73.3±8.3 years and 71.87% were male. According to the analysis of the diaries, the mean scores (visual analog scale) for all symptoms and the performance of activities of daily living ranged between 0.5 and 2.5, being higher in the morning (mean scores between 1.5 and 2.5) than in the afternoon and night (mean scores between 0.5 and 1.5); however, symptom variability was minimal. These results were similar to those obtained in the EPOC-CoVaSy instrument, demonstrating a high correlation between both instruments that allowed to confirm that EPOC-CoVaSy is a useful instrument to measure such variability.  Conclusions. Based on the findings of the present study, it can be concluded that there is a slight variability in COPD symptoms throughout the day, which should be considered when establishing treatment regimens for this disease. Likewise, it was determined that the EPOC-CoVaSy instrument is valid to measure such variability in Colombian patients with COPD.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. Se considera que la variabilidad de los síntomas respiratorios de la enfermedad pulmonar obstructiva crónica (EPOC) es baja o inexistente. Sin embargo, algunos autores afirman que se pueden presentar fluctuaciones.  Objetivos. Describir la variabilidad de síntomas en pacientes con EPOC a lo largo del día y la noche durante cuatro semanas mediante un diario del paciente, y validar un cuestionario desarrollado para tal fin (Instrumento Colombiano Autoadministrado de Variabilidad de Síntomas en EPOC: EPOC-CoVaSy).  Materiales y métodos. Estudio de cohorte realizado en 96 pacientes con EPOC atendidos entre junio y diciembre de 2016 en el Centro de Atención Pulmonar - CAP, en Barranquilla, Colombia, quienes diligenciaron un diario del paciente durante cuatro semanas y, luego de este periodo, el instrumento autoadministrado EPOC-CoVaSy. La independencia y comparación de frecuencias de las variables categóricas y continuas se establecieron mediante las pruebas   %  2 y exacta de Fisher y el coeficiente de correlación de Pearson, respectivamente. Se realizó un MANOVA, utilizando modelos de regresión lineal, para determinar las correlaciones entre los resultados del diario y el instrumento.  Resultados. La edad promedio de los participantes fue 73.3±8.3 años y 71.87% eran hombres. Según el análisis de los diarios, los puntajes promedio (escala visual analógica) para todos los síntomas y el desempeño de actividades diarias oscilaron entre 0.5 y 2.5, siendo más altos en la mañana (puntajes promedio entre 1.5 y 2.5) que en la tarde y noche (puntajes promedio entre 0.5 y 1.5); sin embargo, esta variabilidad fue mínima, lo que coincidió con los resultados obtenidos en el EPOC-CoVaSy, evidenciándose una alta correlación entre ambos instrumentos que permitió confirmar que la herramienta diseñada es útil para medir dicha variabilidad. Conclusiones. Con base en los hallazgos del presente estudio, se puede concluir que existe una leve variabilidad en los síntomas de EPOC a lo largo del día, la cual debe considerarse a la hora de establecer esquemas de tratamiento para esta enfermedad. Asimismo, se estableció que el EPOC-CoVaSy es válido para medir dicha variabilidad en la población colombiana con EPOC.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[COPD]]></kwd>
<kwd lng="en"><![CDATA[Outpatients]]></kwd>
<kwd lng="en"><![CDATA[Diary (MeSH)]]></kwd>
<kwd lng="es"><![CDATA[EPOC]]></kwd>
<kwd lng="es"><![CDATA[Pacientes ambulatorios]]></kwd>
<kwd lng="es"><![CDATA[Diario (DeCS)]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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