<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112022000400202</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v70n4.94464</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Risk factors associated with failed weaning from mechanical ventilation in septic patients admitted to an intensive care unit: a case-control study]]></article-title>
<article-title xml:lang="es"><![CDATA[Factores de riesgo de destete ventilatorio fallido en pacientes sépticos en una unidad de cuidado intensivo: estudio de casos y controles]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ríaseos]]></surname>
<given-names><![CDATA[Lorena Enriquez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcia-Perdomo]]></surname>
<given-names><![CDATA[Herney Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Libre Faculty of Health Sciences ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Valle  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>70</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112022000400202&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112022000400202&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112022000400202&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Several risk factors associated with weaning failure may be observed in septic patients requiring invasive mechanical ventilation.  Objective: To determine the risk factors associated with weaning failure in septic patients admitted to an intensive care unit (ICU) in Cali, Colombia, between January 2014 and June 2018.  Materials and methods: Case-control study conducted in 315 patients who required mechanical ventilation for more than 48 hours and were distributed as follows: 105 cases (weaning failure) and 210 controls (successful weaning). Information about sociodemographic and clinical variables was obtained from their medical records. A bivariate analysis was performed to determine the association between each independent variable and weaning failure. A multivariate analysis was also carried out using a logistic regression model in which the variables with a p&lt;0.20 in the bivariate analysis were entered. A significance level of p&#8804;0.05 was considered.  Results: Requiring mechanical ventilation for more than 7 days (OR: 15.13; 95%CI: 8.25-27.74), having a high APACHE II score (mortality risk &gt;50%) on ICU admission (OR: 3.16; 95%CI: 1.73-5.77), and having diuresis &#8804;0.5 mL/kg/h (OR: 1.87; 95%CI: 1.0-3.50) were significantly associated with weaning failure.  Conclusions: Requiring mechanical ventilation for more than 7 days, having diuresis &#8804;0.5ml/kg/h, as well as a high APACHE ll score on ICU admission were risk factors associated with failed weaning from mechanical ventilation in this study; however, age, blood urea nitrogen, creatinine, and positive fluid balance were not significantly associated with it, despite being described as risk factors in the literature.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. En pacientes sépticos con requerimiento de ventilación mecánica invasiva pueden presentarse diferentes factores de riesgo de destete ventilatorio fallido.  Objetivo. Determinar los factores de riesgo de destete ventilatorio fallido en pacientes sépticos admitidos a una unidad de cuidados intensivos (UCI) de Cali, Colombia, entre enero de 2014 y junio 2018  Materiales y métodos. Estudio de casos y controles realizado en 315 pacientes que requirieron ventilación mecánica por más de 48 horas distribuidos así: 105 casos (destete fallido) y 210 controles (destete exitoso). La información sobre variables sociodemográficas y clínicas se obtuvo a partir de la revisión de historias clínicas. Se realizó un análisis bivariado para determinar las asociaciones de cada variable independiente con el destete fallido y un análisis multivariado mediante un modelo de regresión logística en el que se ingresaron las variables que en el análisis bivariado tuvieron un valor p&lt;0.20. Se consideró un nivel de significancia de p&#8804;0.05.  Resultados. Haber requerido ventilación mecánica por más de 7 días (OR: 15.13; IC95% 8.25-27.74), tener un puntaje APACHE II alto (riesgo de mortalidad &gt;50%) al ingreso a UCI (OR: 3.16; 95%IC: 1.73-5.77) y tener diuresis &#8804;0.5 mL/kg/h (OR: 1.87; IC95% 1.0-3.50) se asociaron significativamente con el destete ventilatorio fallido.  Conclusiones. En el presente estudio, el requerimiento de ventilación mecánica mayor a 7 días, la diuresis &#8804;0.5 mL/kg/h y un puntaje APACHE II alto al ingreso a UCI fueron factores de riesgo para destete ventilatorio fallido, pero no se observó asociación con la edad, el nitrógeno ureico en sangre, la creatinina y el balance de líquidos positivos, a pesar de que estos han sido descritos como factores de riesgo en la literatura.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[Respiration, Artificial]]></kwd>
<kwd lng="en"><![CDATA[Ventilator Weaning (MeSH)]]></kwd>
<kwd lng="es"><![CDATA[Sepsis]]></kwd>
<kwd lng="es"><![CDATA[Respiración artificial]]></kwd>
<kwd lng="es"><![CDATA[Desconexión del ventilador (DeCS)]]></kwd>
</kwd-group>
</article-meta>
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