<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112023000100010</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v71n1.95595</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Prevalence of KRAS, PIK3CA, BRAF and AXIN2 gene mutations in colorectal cancer and their relationship with dental agenesis: a systematic review]]></article-title>
<article-title xml:lang="es"><![CDATA[Prevalencia de mutaciones en los genes KRAS, PIK3CA, BRAF y AXIN2 en cáncer colorrectal y su relación con agenesia dental: revisión sistemática]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sir-Mendoza]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madera]]></surname>
<given-names><![CDATA[Meisser]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Martínez]]></surname>
<given-names><![CDATA[Farith]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Cartagena Faculty of Dentistry Department of Research]]></institution>
<addr-line><![CDATA[Cartagena ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Colombia Faculty of Medicine ]]></institution>
<addr-line><![CDATA[Bogotá D.C]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<volume>71</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112023000100010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112023000100010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112023000100010&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The study of allelic and genotypic frequencies contributes to determining the distribution of genetic variants in different populations and their possible association with biomarkers. This knowledge could improve the decision-making process regarding the management of some diseases such as colorectal cancer (CRC), in which the detection of clinical biomarkers such as dental agenesis could be crucial in clinical practice.  Objective: To evaluate the available scientific evidence on the prevalence of mutations in KRAS, PIK3CA, BRAF and AXIN2 genes and their possible association with tooth agenesis in people with CRC.  Materials and methods: A systematic search was conducted in PubMed, EMBASE and Cochrane Library databases using the following search strategy: type of studies: observational studies reporting the prevalence of KRAS, PIK3CA, BRAF and AXIN2 mutations in people diagnosed with CRC and their possible association with dental agenesis; publication language: English and Spanish; publication period: 2010-2020; search terms: "Genes", "RAS", "Kras", "PIK3CA", "BRAF", "AXIN2", "Mutation", "Polymorphism", "Colorectal Neoplasms" and "Colorectal Cancer", used in different combinations ("AND" and "OR").  Results: The initial search yielded 403 records, but only 30 studies met the eligibility criteria. Of these, 11, 5, 5 and 1 only reported the prevalence of PIK3CA, KRAS, BRAF and AXIN2 mutations, respectively; while 8 reported the prevalence of more than one of these mutations in patients with CRC. The prevalence of KRAS (p.Gly12Asp), PIK3CA (p.Glu545Lys), and BRAF (p.Val600Glu) mutations ranged from 20.5% to 54%, 3.5% to 20.2%, and 2.5% to 12.1%, respectively. There were no findings regarding the association between the occurrence of these mutations and dental agenesis.  Conclusions:  KRAS mutations were the most prevalent; however, there is no evidence on the association between dental agenesis and the occurrence of KRAS, PIK3CA and BRAF germline mutations in individuals with CRC.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción. El estudio de frecuencias alélicas y genotípicas contribuye a determinar la distribución de variantes genéticas en diferentes poblaciones y su posible asociación con biomarcadores. Este conocimiento podría mejorar la toma de decisiones respecto al manejo de algunas enfermedades como el cáncer colorrectal (CCR), en el cual la detección de biomarcadores clínicos como la agenesia dental podría ser crucial en la práctica clínica.  Objetivo. Evaluar la evidencia científica sobre la prevalencia de mutaciones en los genes KRAS, PIK3CA, BRAF y AXIN2 y su posible asociación con la agenesia dental en individuos con CCR.  Materiales y métodos. Se realizó una búsqueda sistemática en PubMed, Embase y Cochrane Library empleando la siguiente estrategia de búsqueda: tipos de estudio: estudios observacionales que reportaran la prevalencia de mutaciones en los genes KRAS, PIK3CA, BRAF y AXIN2 en personas con CCR y su posible asociación con agenesia dental; idioma: inglés y español; periodo de publicación: 2010-2020; términos de búsqueda: "Genes", "RAS", "Kras", "PIK3CA", "BRAF", "AXIN2", "Mutation", "Polymorphism", "Colorectal Neoplasms" y "Colorectal Cancer" en diferentes combinaciones ("AND" y "OR").  Resultados. Se identificaron 403 registros, pero solo 30 cumplieron con los criterios de elegibilidad. De estos, 11, 5, 5 y 1 solo reportaron la prevalencia de mutaciones en PIK3CA, KRAS, BRAF y AXIN2, respectivamente, mientras que 8 reportaron la prevalencia de más de una de estas mutaciones en pacientes con CCR. La prevalencia de mutaciones en los genes KRAS (p.Gly12Asp), PIK3CA (p.Glu545Lys), y BRAF (p.Val600Glu) varió entre 20.5% y 54%, 3.5% y 20.2%, y 2.5% y 12.1%, respectivamente. No hubo hallazgos respecto a la asociación entre la ocurrencia de estas mutaciones y la agenesia dental.  Conclusiones. Las mutaciones en el gen KRAS fueron las más prevalentes; sin embargo, no hay evidencia de la asociación entre agenesia dental y la ocurrencia de mutaciones en los genes KRAS, PIK3CA y BRAF en individuos con CCR.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Anodontia]]></kwd>
<kwd lng="en"><![CDATA[Mutation]]></kwd>
<kwd lng="en"><![CDATA[Prevalence]]></kwd>
<kwd lng="en"><![CDATA[Genes]]></kwd>
<kwd lng="en"><![CDATA[Colorectal Cancer]]></kwd>
<kwd lng="en"><![CDATA[Colorectal Neoplasms (MeSH)]]></kwd>
<kwd lng="es"><![CDATA[Anodoncia]]></kwd>
<kwd lng="es"><![CDATA[Mutación]]></kwd>
<kwd lng="es"><![CDATA[Prevalencia]]></kwd>
<kwd lng="es"><![CDATA[Genes]]></kwd>
<kwd lng="es"><![CDATA[Cáncer colorrectal]]></kwd>
<kwd lng="es"><![CDATA[Neoplasma colorrectal (DeCS)]]></kwd>
</kwd-group>
</article-meta>
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