<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0011</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[rev.fac.med.]]></abbrev-journal-title>
<issn>0120-0011</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional de Colombia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-00112024000100006</article-id>
<article-id pub-id-type="doi">10.15446/revfacmed.v72n1.107193</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Mortality in patients with multidrug-resistant tuberculosis in a tertiary care hospital in Lima, Peru]]></article-title>
<article-title xml:lang="es"><![CDATA[Mortalidad en pacientes con tuberculosis multidrogoresistente en un hospital de tercer nivel de Lima, Perú]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Altamirano-Arauco]]></surname>
<given-names><![CDATA[Milenka]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Casanova-Mendoza]]></surname>
<given-names><![CDATA[Aldo Renato]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salas-López]]></surname>
<given-names><![CDATA[Juan Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Llanos-Tejada]]></surname>
<given-names><![CDATA[Félix Konrad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas-Ponce]]></surname>
<given-names><![CDATA[Kenneth Grenis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Nacional Dos de Mayo  ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Ricardo Palma  ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<volume>72</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-00112024000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-00112024000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-00112024000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: In recent years, an increase in the number of multidrug-resistant (MDR) tuberculosis (MDR-TB) cases has been reported worldwide. This implies an increase in mortality rates due to the complex treatment of MDR-TB and the presence of different risk factors in these patients.  Objective: To determine the risk factors for mortality in patients with MDR-TB treated at the pulmonology service of the Hospital Nacional Dos de Mayo (Lima, Peru) between 2014 and 2018.  Materials and methods: Retrospective case-control study conducted in 305 MDR-TB patients hospitalized between 2014 and 2018 (cases: 62; controls: 243). Cases were defined as patients who died. Data on variables of interest were obtained from medical records. A bivariate and a multivariate analysis (logistic regression model) were performed by calculating odds ratios (crude and adjusted) to determine the association between the variables considered in this study and mortality.  Results: Participants' mean age was 48.2±19.4 years. In the multivariate analysis, having diabetes mellitus (aOR: 8.580, 95%CI: 1.805-40.785), having a history of TB (aOR: 4.923, 95%CI: 1.474-16.446), being an active smoker (aOR: 12.189, 95%CI: 3.047-48.759), using psychoactive drugs (aOR: 9.428, CI95%: 2.737-32.482), and being malnourished (aOR: 6.652, CI95%: 1.432-30.888) were associated with an increased risk of mortality due to MDR-TB.  Conclusions: In this study, several risk factors for mortality in MDR-TB patients were identified. Strategies for the adequate management of MDR-TB, particularly in patients with the mortality risk factors identified here, must be implemented at the Hospital Nacional Dos de Mayo, as well as other hospitals that provide healthcare services to these patients in Lima.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: En los últimos años se ha reportado un aumento en el número de casos de tuberculosis (TB) multidrogoresistente (MDR) a nivel mundial. Esto implica un incremento en las tasas de mortalidad debido a que el tratamiento de la TB-MDR es complejo y a la presencia de diferentes factores de riesgo en estos pacientes.  Objetivo: Determinar los factores de riesgo de mortalidad en pacientes con TB-MDR atendidos en el Servicio de Neumología del Hospital Nacional Dos de Mayo (Lima, Perú) entre 2014 y 2018.  Materiales y métodos: Estudio retrospectivo de casos y controles realizado en 305 pacientes con TB-MDR hospitalizados entre 2014 y 2018 (casos: 62; controles: 243). Los casos se definieron como aquellos pacientes que fallecieron. Los datos de las variables de interés se obtuvieron de las historias clínicas. Se realizó un análisis bivariado y uno multivariado (modelo de regresión logística) mediante el cálculo de odds ratio (crudos y ajustados) para determinar la asociación entre las variables consideradas y la mortalidad.  Resultados: El promedio de edad fue 48.2±19.4 años. En el análisis multivariado, tener diabetes mellitus (ORa: 8.580, IC95%: 1.805-40.785), tener antecedente de TB (ORa: 4.923, IC95%: 1.474-16.446), la presencia de tabaquismo (ORa: 12.189, IC95%: 3.047-48.759), la presencia de consumo activo de sustancias psicoactivas (ORa: 9.428, IC95%: 2.737-32.482) y estar desnutrido (ORa: 6.652, IC95%: 1.432-30.888) se asociaron con un mayor riesgo de mortalidad por TB-MDR.  Conclusiones: En el presente estudio se identificaron varios factores de riesgo de mortalidad en pacientes con TB-MDR. En el Hospital Nacional Dos de Mayo, así como en otros hospitales de Lima que atiendan estos pacientes, se deben implementar estrategias para el manejo adecuado de la TB-MDR, en particular en pacientes con los factores de riesgo de mortalidad aquí identificados.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[Multidrug- Resistance]]></kwd>
<kwd lng="en"><![CDATA[Mortality]]></kwd>
<kwd lng="en"><![CDATA[Risk Factors (MeSH)]]></kwd>
<kwd lng="es"><![CDATA[Tuberculosis resistente a múltiples medicamentos]]></kwd>
<kwd lng="es"><![CDATA[Mortalidad]]></kwd>
<kwd lng="es"><![CDATA[Factores de riesgo (DeCS)]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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