<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0135</journal-id>
<journal-title><![CDATA[Revista de Ciencias Agrícolas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Cienc. Agr.]]></abbrev-journal-title>
<issn>0120-0135</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Nariño]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-01352019000300021</article-id>
<article-id pub-id-type="doi">10.22267/rcia.1936e.103</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Hystometric evaluation of nickel chronic exposure effects on large instestine of adult Wistar male rats]]></article-title>
<article-title xml:lang="es"><![CDATA[Evaluación histométrica de los efectos de la exposición crónica al níquel en el intestino grueso de ratas macho Wistar adultas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Assis Rodrigues]]></surname>
<given-names><![CDATA[Maria Luiza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodrigues Sartori]]></surname>
<given-names><![CDATA[Sirlene Souza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos Totaro]]></surname>
<given-names><![CDATA[Priscila Izabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pinto da Matta]]></surname>
<given-names><![CDATA[Sérgio Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidade Federal de Viçosa  ]]></institution>
<addr-line><![CDATA[ Viçosa]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidade Federal de Viçosa  ]]></institution>
<addr-line><![CDATA[ Viçosa]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade Federal de Minas Gerais  ]]></institution>
<addr-line><![CDATA[ Belo Horizonte]]></addr-line>
<country>Brazil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Federal de Viçosa  ]]></institution>
<addr-line><![CDATA[ Viçosa]]></addr-line>
<country>Brazil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>36</volume>
<numero>spe</numero>
<fpage>21</fpage>
<lpage>30</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-01352019000300021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-01352019000300021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-01352019000300021&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The ingestion of considerable amounts of water or food contaminated with nickel can be very toxic. The present work was conducted aiming to evaluate the effects of nickel exposures on ascending colon of adult Wistar male rats at hystometric level. We used 12 animals that were divided in a control (ingested uncontaminated water) and a nickel-contaminated (i.e., 25 mg de nickel/L of water) groups. Nickel chloride was offered in declorinated water and the experiment had a 56 days exposure period. A portion of the ascending colon was removed of the animals and subjected to hystological labelling processes using blue toluidin (for general hystometric description), Alcian Blue (AB, for acid mucins) and periodic acid-Schiff (PAS) technique (for neutral mucins). The potential differences between groups were desgined by applying the Whitney test and t test (p &lt; 0.05). The crypts were smaller for the nickel-contaminated group, even though these organism exhibited broader and higher crypts. Nickel-contaminated animals exhibited a smaller amount of calyceform cells with AB and PAS positive reactions as well as a less mucus quantities when compared with nickel-uncontaminated animals. Such reductions on the amount of calyceform cells with AB and PAS positive reactions may be related wiht the shallower crypts, which possibly reduced the synthesis and secretion of mucins, compromissing the functional aspects (e.g., lubrification and intestinal mucosa protection) of the nickel-contaminated large intestines. Interestingly, the wider and higher crypts and higher epithelium collumn on the nickel-contaminated animals may represent a relevant trade-off for the intestinal mucosa protection.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La ingestión de cantidades considerables de agua o alimentos contaminados con níquel puede ser muy tóxica. El presente trabajo se realizó con el objetivo de evaluar los efectos de las exposiciones al níquel en el colon ascendente de ratas macho Wistar adultas a nivel histométrico. Utilizamos 12 animales que se dividieron en un control (agua ingerida no contaminada) y un grupo contaminado con níquel (es decir, 25 mg de níquel / L de agua). Se ofreció cloruro de níquel en agua desclorinada y el experimento tuvo un período de exposición de 56 días. Una parte del colon ascendente se retiró de los animales y se sometió a procesos de marcaje histológico usando toluidina azul (para descripción histométrica general), azul de Alcian (AB, para mucinas ácidas) y la técnica periódica de ácido-Schiff (PAS) (para mucinas neutras). Las diferencias potenciales entre los grupos se diseñaron mediante la aplicación de la prueba de Whitney y la prueba t (p &lt;0.05). Las criptas eran más pequeñas para el grupo contaminado con níquel, a pesar de que estos organismos exhibían criptas más amplias y más altas. Los animales contaminados con níquel exhibieron una menor cantidad de células caliceiformes con reacciones positivas AB y PAS, así como una menor cantidad de moco en comparación con los animales no contaminados con níquel. Dichas reducciones en la cantidad de células caliceiformes con reacciones positivas AB y PAS pueden estar relacionadas con las criptas menos profundas, lo que posiblemente redujo la síntesis y secreción de mucinas, comprometiendo los aspectos funcionales (p. Ej., lubricación y protección de la mucosa intestinal) del intestino grueso contaminado con níquel. Curiosamente, las criptas más anchas y más altas y la columna de epitelio más alta en los animales contaminados con níquel pueden representar una compensación relevante para la protección de la mucosa intestinal.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Nickel contamination]]></kwd>
<kwd lng="en"><![CDATA[Toxicology]]></kwd>
<kwd lng="en"><![CDATA[Hystology]]></kwd>
<kwd lng="en"><![CDATA[Morphology]]></kwd>
<kwd lng="es"><![CDATA[Contaminación de níquel]]></kwd>
<kwd lng="es"><![CDATA[Toxicología]]></kwd>
<kwd lng="es"><![CDATA[Histología]]></kwd>
<kwd lng="es"><![CDATA[Morfología]]></kwd>
</kwd-group>
</article-meta>
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