<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-0690</journal-id>
<journal-title><![CDATA[Revista Colombiana de Ciencias Pecuarias]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Colom Cienc Pecua]]></abbrev-journal-title>
<issn>0120-0690</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ciencias Agrarias, Universidad de Antioquia]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-06902019000300166</article-id>
<article-id pub-id-type="doi">10.17533/udea.rccp.v32n3a01</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period]]></article-title>
<article-title xml:lang="es"><![CDATA[La suplementación con L-carnitina disminuye la acumulación de triglicéridos hepáticos en vacas Holstein durante el periodo de transición]]></article-title>
<article-title xml:lang="pt"><![CDATA[Suplementação com L-carnitina diminui o acúmulo de triglicerídeos hepáticos em vacas Holandesas durante o período de transição]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galvis]]></surname>
<given-names><![CDATA[Rubén D]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madrid]]></surname>
<given-names><![CDATA[Liset V]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-Vásquez]]></surname>
<given-names><![CDATA[Nicolás]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Departamento de Producción Animal ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Antioquia Facultad de Ciencias Agrarias Escuela de Medicina Veterinaria]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>32</volume>
<numero>3</numero>
<fpage>166</fpage>
<lpage>174</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-06902019000300166&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-06902019000300166&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-06902019000300166&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics.  Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), &#946;-hydroxybutyrate (&#946;-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions.  Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p&gt;0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p&lt;0.05). This decrease in hepatic triglycerides could be due to increased fatty acid oxidation. L-carnitine supplementation significantly increased (p&lt;0.05) blood urea concentration, possibly through stimulation of the urea cycle, as previously described in other species.  Conclusion: Supplementation with L-carnitine decreased the hepatic concentration of triglycerides, possibly due to increased liver oxidation of fatty acids.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: El incremento en la utilización de reservas corporales durante el periparto en vacas exige una alta disponibilidad de L-carnitina, la cual puede ser limitante bajo las condiciones propias de producción del trópico alto colombiano.  Objetivo: Evaluar el potencial lipotrópico de la L-carnitina en vacas lecheras Holstein durante el periodo de transición a la lactancia.  Métodos:  Se suministraron dosis de 0, 100 y 200 g/d de fumarato de L-carnitina a 21 vacas Holstein a partir del d 260 de gestación y hasta el d 20 postparto. Se determinaron las concentraciones hepáticas de triacilglicéridos, carnitina total, carnitina libre y acil carnitina, y las concentraciones plasmáticas de ácidos grasos no esterificados (NEFA), &#946;-hidroxibutirato (&#946;-HB) y urea. Un análisis de medidas repetidas fue usado para determinar los efectos de la dosis, el periodo de medición, y sus interacciones.  Resultados: Las concentraciones hepáticas de triglicéridos y de las diferentes formas de carnitina no difirieron significativamente (p&gt;0,05) entre periodos de muestreo. La concentración hepática de triglicéridos fue baja, y mostró una disminución significativa (p&lt;0,05) en respuesta a la suplementación con 200 g/d de fumarato de L-carnitina. La disminución en los triglicéridos hepáticos podría deberse a un aumento en la oxidación de ácidos grasos. La suplementación con L-carnitina aumentó significativamente (p&lt;0,05) la concentración de urea en sangre, posiblemente a través de un mecanismo de estimulación del ciclo de la urea, descrito previamente en otras especies.  Conclusión: La suplementación con L-carnitina disminuyó la concentración hepatica de trigliceridos, debido posiblemente a un aumento en la oxidación de ácidos grasos en hígado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo  Antecedentes: O aumento do uso de reservas corporais durante o periparto requer alta disponibilidade de L-carnitina, que pode ser limitante nas condições de produção no trópico alto colombiano.  Objetivo: Avaliar o potencial lipotrópico da L-carnitina em vacas leiteiras Holstein durante o período de transição para a lactação.  Métodos: Quantidades de 0, 100 e 200 g/d de fumarato de L-carnitina foram administradas a 21 vacas holandesas durante o d 260 da gestação e até ao d 20 pós-parto. Foram determinadas as concentrações hepáticas de triacilglicerídeos, carnitina total, carnitina livre e acil carnitina e as concentrações plasmáticas de ácidos graxos não esterificados (NEFA), &#946;-hidroxibutirato (&#946;-HB) e ureia. Uma análise das medidas repetidas foi usada para determinar os efeitos da dose, período de medição e suas interações.  Resultados: As concentrações hepáticas de triglicerídeos e as diferentes formas de carnitina não diferiram significativamente entre os períodos de amostragem (p&gt;0,05). A concentração hepática de triglicerídeos foi baixa e mostrou diminuição significativa (p&lt;0,05) em resposta à suplementação com 200 g/d de fumarato de L-carnitina. A diminuição dos triglicerídeos hepáticos pode ser devido a um aumento na oxidação de ácidos graxos. A suplementação com L-carnitina aumentou significativamente (p&lt;0,05) a concentração de ureia no sangue, possivelmente através de um mecanismo de estimulação do ciclo da ureia previamente descrito em outras espécies.  Conclusão: A suplementação com L-carnitina diminuiu a concentração hepática de triglicerídeos, possivelmente devido ao aumento da oxidação de ácidos graxos no fígado.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[dairy cows]]></kwd>
<kwd lng="en"><![CDATA[lipid metabolism]]></kwd>
<kwd lng="en"><![CDATA[L-carnitine]]></kwd>
<kwd lng="en"><![CDATA[lipidosis]]></kwd>
<kwd lng="en"><![CDATA[lipotropic factors]]></kwd>
<kwd lng="en"><![CDATA[metabolic disorders]]></kwd>
<kwd lng="en"><![CDATA[peripartum]]></kwd>
<kwd lng="es"><![CDATA[factores lipotrópicos]]></kwd>
<kwd lng="es"><![CDATA[lipidosis]]></kwd>
<kwd lng="es"><![CDATA[L-carnitina]]></kwd>
<kwd lng="es"><![CDATA[metabolismo lipídico]]></kwd>
<kwd lng="es"><![CDATA[periparto]]></kwd>
<kwd lng="es"><![CDATA[trastornos metabólicos]]></kwd>
<kwd lng="es"><![CDATA[vacas lecheras]]></kwd>
<kwd lng="pt"><![CDATA[distúrbios metabólicos]]></kwd>
<kwd lng="pt"><![CDATA[fatores lipotrópicos]]></kwd>
<kwd lng="pt"><![CDATA[lipidose]]></kwd>
<kwd lng="pt"><![CDATA[L-carnitina]]></kwd>
<kwd lng="pt"><![CDATA[metabolismo lipídico]]></kwd>
<kwd lng="pt"><![CDATA[periparto]]></kwd>
<kwd lng="pt"><![CDATA[vacas leiteiras]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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