<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-1751</journal-id>
<journal-title><![CDATA[Revista Colombiana de Estadística]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Colomb.Estad.]]></abbrev-journal-title>
<issn>0120-1751</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Estadística - Universidad Nacional de Colombia.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-17512007000100003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Una introducción a los diseños óptimos]]></article-title>
<article-title xml:lang="en"><![CDATA[An Introduction to Optimal Designs]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[LÓPEZ]]></surname>
<given-names><![CDATA[VÍCTOR IGNACIO]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[RAMOS]]></surname>
<given-names><![CDATA[ROGELIO]]></given-names>
</name>
<xref ref-type="aff" rid="A02"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidad Nacional de Colombia Escuela de Estadística ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="A02">
<institution><![CDATA[,CIMAT Centro de Investigación en Matemáticas ]]></institution>
<addr-line><![CDATA[Guanajuato ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>15</day>
<month>06</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub">
<day>15</day>
<month>06</month>
<year>2007</year>
</pub-date>
<volume>30</volume>
<numero>1</numero>
<fpage>37</fpage>
<lpage>51</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-17512007000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-17512007000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-17512007000100003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Introducimos varios conceptos utilizados en la teoría de diseños de experimentos óptimos. Definimos criterios de optimalidad utilizados en esta área y exploramos sus propiedades. Se listan algunos resultados importantes para encontrar diseños óptimos para modelos lineales y no lineales, entre ellos teoremas de equivalencia. Finalmente se presentan algunos ejemplos típicos donde se aplica la teoría vista anteriormente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[We introduce several concepts used in optimal experimental design. Optimality criteria used in this area are defined and their properties are explored. Some important results for finding optimal designs in linear and nonlinear models are listed, specially equivalence theorems are formulated. Finally, we present some examples where that theory is applied.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[función de información]]></kwd>
<kwd lng="es"><![CDATA[matriz de información]]></kwd>
<kwd lng="es"><![CDATA[criterios de optimalidad]]></kwd>
<kwd lng="es"><![CDATA[teoremas de equivalencia]]></kwd>
<kwd lng="es"><![CDATA[modelos de regresión no lineal]]></kwd>
<kwd lng="en"><![CDATA[Information function]]></kwd>
<kwd lng="en"><![CDATA[Information matrix]]></kwd>
<kwd lng="en"><![CDATA[Optimality criteria]]></kwd>
<kwd lng="en"><![CDATA[Equivalence theorems]]></kwd>
<kwd lng="en"><![CDATA[Nonlinear regression models]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[   <font face="verdana" size="2">      <p><b><font size="4">    <center>Una introducci&oacute;n a los dise&ntilde;os &oacute;ptimos</center></font> </b></p>      <p><b><font size="3">    <center>An Introduction to Optimal Designs</center></font> </b></p>      <p>    <center>V&Iacute;CTOR IGNACIO L&Oacute;PEZ<sup>1</sup>, ROGELIO RAMOS<sup>2</sup></center></p>      <p> <sup>1</sup>Escuela de Estad&iacute;stica, Universidad Nacional de Colombia, Medell&iacute;n. Profesor asistente. Estudiante de doctorado en Ciencias con Orientaci&oacute;n en Probabilidad y Estad&iacute;stica. E-mail: <a href="mailto:vilopez@unalmed.edu.co">vilopez@unalmed.edu.co</a>    <br>  <sup>2</sup>Centro de Investigaci&oacute;n en Matem&aacute;ticas (CIMAT), Guanajuato, Gto., M&eacute;xico. Investigador titular. E-mail: <a href="mailto:rramosq@cimat.mx">rramosq@cimat.mx</a> </p>  <hr size=1>      <p><b>    ]]></body>
<body><![CDATA[<center>Resumen</center></b></p>      <p>  Introducimos varios conceptos utilizados en la teor&iacute;a de dise&ntilde;os de experimentos &oacute;ptimos. Definimos criterios de optimalidad utilizados en esta &aacute;rea y exploramos sus propiedades. Se listan algunos resultados importantes para encontrar dise&ntilde;os &oacute;ptimos para modelos lineales y no lineales, entre ellos teoremas de equivalencia. Finalmente se presentan algunos ejemplos t&iacute;picos donde se aplica la teor&iacute;a vista anteriormente. </p>      <p><b>Palabras clave:</b> funci&oacute;n de informaci&oacute;n, matriz de informaci&oacute;n, criterios de optimalidad, teoremas de equivalencia, modelos de regresi&oacute;n no lineal.</p>  <hr size=1>      <p><b>    <center>Abstract</center></b></p>      <p> We introduce several concepts used in optimal experimental design. Optimality criteria used in this area are defined and their properties are explored. Some important results for finding optimal designs in linear and nonlinear models are listed, specially equivalence theorems are formulated. Finally, we present some examples where that theory is applied. </p>      <p><b>Key words:</b> Information function, Information matrix, Optimality criteria, Equivalence theorems, Nonlinear regression models.</p>  <hr size=1>      <p>Texto completo disponible en <a href="pdf/rce/v30n1/v30n1a03.pdf">PDF</a></p>  <hr size=1>      <p><b><font size="3">Referencias</font></b></p>      <!-- ref --><p>1. Atkinson, A. C. (1996), ‘The Uselfulness of Optimum Experimental Designs’, <i>Journal of the Royal Statistical Society. Series B (Methodological)</i> <b>58</b>(1), 59–76.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000022&pid=S0120-1751200700010000300001&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p>2. Atkinson, A. C. & Cox, D. R. (1974), ‘Planning Experiments for Discriminating Between Models’, <i>Journal of the Royal Statistical Society. Series B (Methodological)</i> <b>36</b>(3), 321–348.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000023&pid=S0120-1751200700010000300002&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p>3. Atkinson, A. C. & Donev, A. N. (1992), <i>Optimum Experimental Designs</i>, Oxford Science Publications, New York.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000024&pid=S0120-1751200700010000300003&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p>4. Atkinson, A. C. & Fedorov, V. V. (1975), ‘Optimal Design: Experiments for Discriminating Between Several Models’, <i>Biometrika</i> <b>62</b>(2), 289–303.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000025&pid=S0120-1751200700010000300004&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p>5. Biedermann, S., Dette, H. & Pepelyshev, A. 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(2005), ‘Optimal Design for Goodness-of-Fit of the Michaelis-Menten Enzyme Kinetic Function’, <i>Journal of the American Statistical Association</i> <b>100</b>(472), 1370–1381.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000033&pid=S0120-1751200700010000300011&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p>12. Ford, I., Tornsney, B. & Wu, C. F. J. 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