<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-1751</journal-id>
<journal-title><![CDATA[Revista Colombiana de Estadística]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Colomb.Estad.]]></abbrev-journal-title>
<issn>0120-1751</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Estadística - Universidad Nacional de Colombia.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-17512008000200009</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Experimental Sequential Designs for Logistic Regression Models]]></article-title>
<article-title xml:lang="es"><![CDATA[Diseños experimentales secuenciales para modelos logísticos de regresión]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[DE ZAN]]></surname>
<given-names><![CDATA[ARTURO T.]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Universidad de la Sabana Facultad de Ingeniería Departamento de Ingeniería]]></institution>
<addr-line><![CDATA[Chía ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>15</day>
<month>12</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="epub">
<day>15</day>
<month>12</month>
<year>2008</year>
</pub-date>
<volume>31</volume>
<numero>2</numero>
<fpage>261</fpage>
<lpage>291</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-17512008000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-17512008000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-17512008000200009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[When the usual hypotheses of normality and constant variance do not hold (e.g. in binomial or Bernoulli processes), the problem of choosing appropriate designs creates problems to researches when pursuing a sequential exploration of process. This paper is based on De Zan (2006), where the author proposes two criteria to evaluate design strategies, that take the amount of information as the main evaluation tool. One into account the information of the fitted model, and the other explores the information that is contained on the approximation of a set of the best conditions of factors found on a fitted model. An example of how these strategies work is also given through a simulation using R software.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Cuando los supuestos habituales de normalidad y varianza constante no se cumplen (e.g. en procesos de Bernoulli o binomiales), el problema de la elección de diseños adecuados ocasiona cierta dificultad a los experimentadores, especialmente cuando lo que se persigue es una exploración secuencial del proceso. Este artículo está basado en De Zan (2006), en donde se proponen dos criterios para evaluar estrategias de diseño. Una de ellas toma en cuenta la cantidad de información contenida en el modelo ajustado, mientras que la otra explora la información contenida en las mejores condiciones de experimentación encontradas en el modelo ajustado. Se desarrolla un ejemplo simulado con el paquete R acerca de cómo funcionan estas estrategias.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Factorial Design]]></kwd>
<kwd lng="en"><![CDATA[Response Surface Design]]></kwd>
<kwd lng="en"><![CDATA[Sequential Design of Experiments]]></kwd>
<kwd lng="en"><![CDATA[Generalized Linear Model]]></kwd>
<kwd lng="en"><![CDATA[Logistic Regression]]></kwd>
<kwd lng="en"><![CDATA[Fisher Information Matrix]]></kwd>
<kwd lng="es"><![CDATA[diseño factorial]]></kwd>
<kwd lng="es"><![CDATA[metodología de superficie de respuesta]]></kwd>
<kwd lng="es"><![CDATA[diseño de experimentos secuenciales]]></kwd>
<kwd lng="es"><![CDATA[modelo lineal generalizado]]></kwd>
<kwd lng="es"><![CDATA[regresión logística]]></kwd>
<kwd lng="es"><![CDATA[matriz de información de Fisher]]></kwd>
</kwd-group>
</article-meta>
</front><body><![CDATA[  <font size="2" face="verdana">      <p> <b> <font size="4">     <center> Experimental Sequential Designs for Logistic Regression Models </center> </font> </b> </p>      <p> <b> <font size="3">     <center> Dise&ntilde;os experimentales secuenciales para modelos log&iacute;sticos de regresi&oacute;n </center> </font> </b> </p>      <p>     <center> ARTURO T. DE ZAN<sup>1</sup> </center> </p>      <p> <sup>1</sup>Universidad de la Sabana, Facultad de Ingenier&iacute;a, Departamento de Ingenier&iacute;a, Ch&iacute;a, Colombia. Assistant Professor. Email: <a href="mailto:arturo.de.zan@unisabana.edu.co">arturo.de.zan@unisabana.edu.co</a>     <br> </p>  <hr size="1">      <p> <b>     ]]></body>
<body><![CDATA[<center> Abstract </center> </b> </p>      <p> When the usual hypotheses of normality and constant variance do not hold (<i>e.g.</i> in binomial or Bernoulli processes), the problem of choosing appropriate designs creates problems to researches when pursuing a sequential exploration of process. This paper is based on De Zan (2006), where the author proposes two criteria to evaluate design strategies, that take the amount of information as the main evaluation tool. One into account the information of the fitted model, and the other explores the information that is contained on the approximation of a set of the best conditions of factors found on a fitted model. An example of how these strategies work is also given through a simulation using <i>R</i> software. </p>      <p> <b> Key words: </b> Factorial Design, Response Surface Design, Sequential Design of Experiments, Generalized Linear Model, Logistic Regression, Fisher Information Matrix. </p>  <hr size="1">      <p> <b>     <center> Resumen </center> </b> </p>      <p> Cuando los supuestos habituales de normalidad y varianza constante no se cumplen (<i>e.g.</i> en procesos de Bernoulli o binomiales), el problema de la elecci&oacute;n de dise&ntilde;os adecuados ocasiona cierta dificultad a los experimentadores, especialmente cuando lo que se persigue es una exploraci&oacute;n secuencial del proceso. Este art&iacute;culo est&aacute; basado en De Zan (2006), en donde se proponen dos criterios para evaluar estrategias de dise&ntilde;o. Una de ellas toma en cuenta la cantidad de informaci&oacute;n contenida en el modelo ajustado, mientras que la otra explora la informaci&oacute;n contenida en las mejores condiciones de experimentaci&oacute;n encontradas en el modelo ajustado. Se desarrolla un ejemplo simulado con el paquete <i>R</i> acerca de c&oacute;mo funcionan estas estrategias. </p>      <p> <b> Palabras clave: </b> dise&ntilde;o factorial, metodolog&iacute;a de superficie de respuesta, dise&ntilde;o de experimentos secuenciales, modelo lineal generalizado, regresi&oacute;n log&iacute;stica, matriz de informaci&oacute;n de Fisher. </p>  <hr size="1">      <p> Texto completo disponible en <a href="pdf/rce/v31n2/v31n2a09.pdf">PDF</a> </p>  <hr size="1">      <p> <b> <font size="3"> References </font> </b> </p>       <!-- ref --><p> 1. Atkinson, A. C. 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(1993), <i>Optimal Design of Experiments</i>, John Wiley & Sons, New York, United States. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000049&pid=S0120-1751200800020000900028&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p> 29. R Development Core Team, (2006), <i>R: A Language and Environment for Statistical Computing</i>, R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. *<a href="http://www.R-project.org" target="_blank">http://www.R-project.org</a> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000050&pid=S0120-1751200800020000900029&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><!-- ref --><p> 30. Robinson, K. S. & Khuri, A. I. (2003), `Quantile Dispersion Graphs for Evaluating and Comparing Designs for Logistic Regression Models´, <i>Computational Statistics & Data Analysis</i> <b>43</b>, 47-62. &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;[&#160;<a href="javascript:void(0);" onclick="javascript: window.open('/scielo.php?script=sci_nlinks&ref=000051&pid=S0120-1751200800020000900030&lng=','','width=640,height=500,resizable=yes,scrollbars=1,menubar=yes,');">Links</a>&#160;]<!-- end-ref --><center> <b>&#91;Recibido en septiembre de 2007. Aceptado en agosto de 2008&#93;</b> </center> <hr size="1">      ]]></body>
<body><![CDATA[<p> Este art&iacute;culo se puede citar en <i>LaTeX</i> utilizando la siguiente referencia bibliogr&aacute;fica de <i>BibTeX</i>: </p> <code><font size="2">@ARTICLE{RCEv31n2a09,    <br>  &nbsp;&nbsp;&nbsp; AUTHOR &nbsp;= {De Zan, Arturo T.},    <br>  &nbsp;&nbsp;&nbsp; TITLE &nbsp; = {{Experimental Sequential Designs for Logistic Regression Models}},    <br>  &nbsp;&nbsp;&nbsp; JOURNAL = {Revista Colombiana de Estad&iacute;stica},    <br> &nbsp;&nbsp;&nbsp; YEAR &nbsp;&nbsp; = {2008},    <br> &nbsp;&nbsp;&nbsp; volume &nbsp;= {31},    <br> &nbsp;&nbsp;&nbsp; number &nbsp;= {2},    <br> &nbsp;&nbsp;&nbsp; pages &nbsp; = {261-291}    <br> }</font></code>  <hr size="1"> </font>      ]]></body><back>
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