0120-1751 0120-1751 S0120-17512018000200191 10.15446/rce.v41n2.63332 USA 00 12 2018 00 12 2018 41 2 191 233

1984 40 1071-8 2017 74 919-26 2008 32 1453-8 1993 88 9-25 1989 Center for Drug Evaluation and Research 2001 Center for Drug Evaluation and Research 2003 2011 2016 35 4077-92 2013 52 1033-43 2004 58 161-78 2003 26 457-94 2004 1989 10 237-43 2001 29 573-95 2004 2006 29 221-38 1978 46 1251-71 1953 9 226-52 2014 222 171-8 2009 32 17-31 1967 221-33 2015 2006 71 659-90 2007 72 505-33 1982 38 963-74 2015 815-30 1978 46 69-85 1972 135 370-84 2016 15 365-72 2009 2005 128 301-23 1966 2002 2nd Edition 2004 3 133-42 1998 17 2849-64 2003 2nd Edition 2005 40 281-301 1982 50 1-25