<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-2448</journal-id>
<journal-title><![CDATA[Acta Medica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Med Colomb]]></abbrev-journal-title>
<issn>0120-2448</issn>
<publisher>
<publisher-name><![CDATA[Asociacion Colombiana de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-24482018000200090</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nuevo dispositivo de micronebulización con control continuo de la fracción inspirada de oxígeno ("CONTROLizer")]]></article-title>
<article-title xml:lang="en"><![CDATA[New micronebulizer device with continuous control of the inspired oxygen fraction ("CONTROLizer")]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orozco Levi PhD]]></surname>
<given-names><![CDATA[Mauricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Sarmiento PhD]]></surname>
<given-names><![CDATA[Alba]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Espitia]]></surname>
<given-names><![CDATA[Ángela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Saavedra]]></surname>
<given-names><![CDATA[María Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mogollón]]></surname>
<given-names><![CDATA[Melissa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cáceres MsC, PhD]]></surname>
<given-names><![CDATA[Diana Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte Reyes]]></surname>
<given-names><![CDATA[Rubén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Serrano MsC]]></surname>
<given-names><![CDATA[Norma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[Leonardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sarmiento]]></surname>
<given-names><![CDATA[Eugenio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pizarro]]></surname>
<given-names><![CDATA[Camilo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gea i Guiral PhD]]></surname>
<given-names><![CDATA[Joaquín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Hospital Internacional de Colombia Servicio de Neumología]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Servicio de Neumología Unidad de Investigaciones]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Hospital Internacional de Colombia Unidad de Terapia Respiratoria]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Hospital Internacional de Colombia Servicio de Neumología]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Hospital Internacional de Colombia ]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Hospital Internacional de Colombia Servicio de Neumología]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Unidad de Cuidado Crítico y Vigilancia Intensiva ]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Hospital Internacional de Colombia Unidad de Investigaciones, Desarrollo e Innovación ]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af9">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Hospital Internacional de Colombia ]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="A10">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Unidad de Diseño y Desarrollo ]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="A11">
<institution><![CDATA[,Fundación Cardiovascular de Colombia Unidad de Cuidado Crítico y Vigilancia Intensiva ]]></institution>
<addr-line><![CDATA[Floridablanca ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="A12">
<institution><![CDATA[,Hospital del Mar Servicio de Neumología ]]></institution>
<addr-line><![CDATA[Barcelona ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2018</year>
</pub-date>
<volume>43</volume>
<numero>2</numero>
<fpage>90</fpage>
<lpage>99</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-24482018000200090&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-24482018000200090&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-24482018000200090&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Una de las técnicas más comunes de tratamiento respiratorio es la nebulización de medicamentos para administrarlos por vía inhalada utilizando oxígeno como propelente, el cual a su vez es considerado un fármaco que puede generar efectos adversos relacionados con la dosificación. El objetivo de esta investigación fue diseñar, desarrollar y analizar un sistema dual de micronebulización con control preciso de la FIO2.  Métodos: se diseñó, construyó y evaluó un modelo virtual y un prototipo funcional siguiendo la metodología de bioingeniería de un nuevo dispositivo de micronebulización con control de FIO2. Se evaluó el funcionamiento del dispositivo y su impacto en voluntarios sanos y pacientes hospitalizados mediante escalas psicométricas específicas.  Resultados: se conceptualizó, diseñó y construyó un dispositivo que integra un micronebulizador (recipiente), que permite nebulizar suero fisiológico o soluciones de diversos fármacos basado en la presurización de un gas propelente (aire u oxígeno) junto a un mecanismo de ajuste de la fracción inspirada de O2 (mínimo 21%; máximo 99%). Los límites (máximo y mínimo) de flujo recomendado para generar el aerosol son 6-8 l/min. En ningún caso de uso se presentaron complicaciones.  Conclusiones: CONTROLizer es un dispositivo integrado dual y no-invasivo para la micronebulización de soluciones respiratorias y control continuo de la fracción inspirada de oxígeno. Por sus cualidades y funcionamiento, el dispositivo fue percibido como adecuado y seguro para aplicarse en individuos sanos y pacientes ingresados tanto en salas de cuidados intensivos como de hospitalización convencional. (Acta Med Colomb 2018; 43: 90-99).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract One of the most common techniques of respiratory treatment is the nebulization of medications to be administered by inhalation using oxygen as a propellant, which in turn is considered a drug that can generate adverse effects related to the dosage. The objective of this research was to design, develop and analyze a dual micronebulization system with precise control of FIO2.  Methods: a virtual model and a functional prototype were designed, constructed and evaluated following the bioengineering methodology of a new micronebulizer device with FIO2 control. The functioning of the device and its impact on healthy volunteers and hospitalized patients were evaluated through specific psychometric scales.  Results: a device that integrates a micronebulizer (container), which allows to nebulize physiological saline or solutions of diverse drugs based on the pressurization of a propellant gas (air or oxygen) along with a mechanism of adjustment of the fraction of inspired oxygen (minimum 21%, maximum 99%), was conceptualized, designed and constructed. The limits (maximum and minimum) of recommended flow to generate the aerosol are 6-8 l / min. In no case of use complications occurred.  Conclusions: CONTROLizer is a dual and non-invasive integrated device for the micronebulization of respiratory solutions and continuous control of the fraction of inspired oxygen. Due to its qualities and functioning, the device was perceived as adequate and safe to be applied in healthy individuals and patients admitted in both intensive care and conventional hospitalization rooms. (Acta Med Colomb 2018; 43: 90-99).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[oxigenoterapia]]></kwd>
<kwd lng="es"><![CDATA[insuficiencia respiratoria]]></kwd>
<kwd lng="es"><![CDATA[hipercapnia]]></kwd>
<kwd lng="es"><![CDATA[dispositivos médicos]]></kwd>
<kwd lng="es"><![CDATA[micronebulización]]></kwd>
<kwd lng="en"><![CDATA[oxygen therapy]]></kwd>
<kwd lng="en"><![CDATA[respiratory failure]]></kwd>
<kwd lng="en"><![CDATA[hypercapnia]]></kwd>
<kwd lng="en"><![CDATA[medical devices]]></kwd>
<kwd lng="en"><![CDATA[micronebulization]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[West]]></surname>
<given-names><![CDATA[JB]]></given-names>
</name>
</person-group>
<source><![CDATA[Fisiología respiratoria]]></source>
<year>2005</year>
<edition>7a</edition>
<publisher-name><![CDATA[Editorial Panamericana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bott]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Blumenthal]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Buxton]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Eilum]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Falconer]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Garrod]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[British Thoracic Society Physiotherapy Guideline Development Group Guidelines for the physiotherapy management of the adult, medical, spontaneously breathing patient]]></article-title>
<source><![CDATA[Thorax]]></source>
<year>2009</year>
<volume>64</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>i1-51</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gardenhire]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<name>
<surname><![CDATA[Ari]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hess]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Myers]]></surname>
<given-names><![CDATA[TR]]></given-names>
</name>
</person-group>
<source><![CDATA[A guide to aerosol delivery devices for respiratory therapists 3rd]]></source>
<year>2013</year>
<publisher-name><![CDATA[Ed American Association for Respiratory Care]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Markovitz]]></surname>
<given-names><![CDATA[GH]]></given-names>
</name>
<name>
<surname><![CDATA[Colthurst]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Storer]]></surname>
<given-names><![CDATA[TW]]></given-names>
</name>
<name>
<surname><![CDATA[Cooper]]></surname>
<given-names><![CDATA[CB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effective inspired oxygen concentration measured via transtracheal and oral gas analysis]]></article-title>
<source><![CDATA[Respir Care]]></source>
<year>2010</year>
<volume>55</volume>
<page-range>453-9</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gea]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Orozco-Levi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gallart]]></surname>
<given-names><![CDATA[Ll]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Increased inspiratory oxygen fractions (FiO2) using a conventional delivery nebulizer]]></article-title>
<source><![CDATA[Arch Bronconeumol]]></source>
<year>2010</year>
<volume>46</volume>
<page-range>230-7</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kallet]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Matthay]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hyperoxic Acute Lung Injury]]></article-title>
<source><![CDATA[Respir Care]]></source>
<year>2013</year>
<volume>58</volume>
<page-range>123-41</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Higgins]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Oxygen versus medical air for nebulisers in patients with COPD. Evidence Centre Critical Appraisal]]></source>
<year>2003</year>
<page-range>1-8</page-range><publisher-loc><![CDATA[Clayton (Australia) ]]></publisher-loc>
<publisher-name><![CDATA[Monash University]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Fletcher]]></surname>
<given-names><![CDATA[DF]]></given-names>
</name>
<name>
<surname><![CDATA[Traini]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[H-K]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of computational approaches in inhaler development]]></article-title>
<source><![CDATA[Advanced Drug Delivery Reviews]]></source>
<year>2012</year>
<volume>64</volume>
<page-range>312-22</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perdigones]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Luque]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Quero]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[PDMS microdevice for precise liquid aspiration in the submicroliter range based on the Venturi effect]]></article-title>
<source><![CDATA[Microelectronic Engineering]]></source>
<year>2010</year>
<volume>87</volume>
<page-range>2103-9</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Streiner]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Norman]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Cairney]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Health Measurement Scales: A Practical Guide to Their Development and Use]]></source>
<year>2015</year>
<edition>5th</edition>
<publisher-loc><![CDATA[Great Clarendon ]]></publisher-loc>
<publisher-name><![CDATA[Oxford University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="">
<source><![CDATA[]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rau]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Ari]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Restrepo]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Performance comparison of nebulizer designs constant-output, breath-enhanced, and dosimetric]]></article-title>
<source><![CDATA[Respir Care]]></source>
<year>2004</year>
<volume>49</volume>
<page-range>174-9</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ward]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[High-Flow Oxygen Administration by Nasal Cannula for Adult and Perinatal Patients]]></article-title>
<source><![CDATA[Respir Care]]></source>
<year>2013</year>
<volume>58</volume>
<page-range>98-122</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pierson]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Oxygen in Respiratory Care: A Personal Perspective from 40 Years in the Field]]></article-title>
<source><![CDATA[Respir Care]]></source>
<year>2013</year>
<volume>58</volume>
<page-range>196-204</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dolovich]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Ahrens]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
<name>
<surname><![CDATA[Hess]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Device selection and outcomes of aerosol therapy evidence-based guidelines: American College of Chest Physicians/ American College of Asthma, Allergy, and Immunology]]></article-title>
<source><![CDATA[Chest]]></source>
<year>2005</year>
<volume>127</volume>
<page-range>335-71</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
