<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-2448</journal-id>
<journal-title><![CDATA[Acta Medica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Med Colomb]]></abbrev-journal-title>
<issn>0120-2448</issn>
<publisher>
<publisher-name><![CDATA[Asociacion Colombiana de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-24482020000300028</article-id>
<article-id pub-id-type="doi">10.36104/amc.2020.1880</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Hydroxychloroquine for treatment of SARS-CoV-2 infection An exploratory review]]></article-title>
<article-title xml:lang="es"><![CDATA[Hidroxicloroquina para manejo de infección por SARS-CoV-2 Una revisión exploratoria]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bernal,]]></surname>
<given-names><![CDATA[Édgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Zea,]]></surname>
<given-names><![CDATA[Ana Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salazar-Rey,]]></surname>
<given-names><![CDATA[Milton]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez-Laiton,]]></surname>
<given-names><![CDATA[Édgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Camacho-López]]></surname>
<given-names><![CDATA[Paul Anthony]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Bucaramanga  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Clínica FOSCAL Centro Urológico ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Bucaramanga  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma de Bucaramanga  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Autónoma de Bucaramanga  ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>45</volume>
<numero>3</numero>
<fpage>28</fpage>
<lpage>40</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-24482020000300028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-24482020000300028&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-24482020000300028&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: hydroxychloroquine has been recommended in this pandemic as a possible effective treatment for COVID-19. This is because Chinese experts have demonstrated its ability to inhibit viral replication through various mechanisms. At this juncture, it is vitally important to understand the latest research and clinical trials regarding an effective treatment regimen which would help improve the treatment of patients with SARS-CoV-2 infection.  Objective: to present the available information regarding the use of hydroxychloroquine as a treatment option for patients infected with SARS-CoV-2.  Material and methods: a review was carried out following the methodological framework proposed by Arksey and O'Malley. The data bases used were: PubMed, MedLine, Lilacs, Scopus, Clinical Trials, Cochrane and CNKI. Only texts in Spanish and English were included. Finally, the pertinent studies for this review were described and summarized.  Results: a total of 87 academic articles were included in the review, including experimental and non-experimental studies, all containing evidence regarding the use of hydroxychloroquine in COVID-19.  Conclusions: To date, there is no available substantiating scientific data with enough evidence to support the use of hydroxychloroquine as a pharmacological treatment for the current pandemic. Two randomized clinical trials contradict each other regarding the efficacy of hydroxychloroquine. However, they both share methodological errors and have small sample sizes. A single nonrandomized trial with the same errors shows efficacy of hydroxychloroquine. As far as the safety profile, there is data showing a lower rate of adverse effects for hydroxychloroquine compared with chloroquine, so its use would be preferred if it were to be proven effective against COVID-19. There are several randomized clinical trials underway which, it is hoped, will answer the questions raised by the literature review.(Acta Med Colomb 2020; 45. DOI:https://doi.org/10.36104/amc.2020.1880).]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: la hidroxicloroquina se ha venido postulando en estos tiempos de pandemia como posible tratamiento eficaz frente a COVID-19. Esto ya que se ha demostrado por expertos chinos su capacidad para inhibir la replicación viral usando distintos mecanismos. En este momento es de vital importancia tener conocimiento acerca de las últimas investigaciones y ensayos clínicos en lo que respecta a un esquema de tratamiento efectivo que ayude a un mejor manejo de pacientes con infección por SARS-CoV-2.  Objetivo: presentar la información disponible sobre el uso de hidroxicloroquina como opción de manejo para pacientes infectados por SARS-CoV-2.  Material y métodos: se realizó una revisión siguiendo el marco metodológico sugerido por Arksey y O'Malley. Las bases de datos utilizadas fueron: PubMed, MedLine, Lilacs, Scopus, Clinical Trials, Cochrane y CNKI. Se incluyeron únicamente textos en español e inglés, finalmente se realizó una caracterización y resumen de los estudios pertinentes para esta revisión.  Resultados: se incluyeron en la revisión 87 artículos académicos incluyendo estudios experimentales y no experimentales; todos con evidencia sobre el uso de hidroxicloroquina en COVID-19.  Conclusiones: A la fecha no hay información científica disponible que sustente y tenga la suficiente evidencia para soportar el uso de la hidroxicloroquina como tratamiento farmacológico en la pandemia actual. Dos ensayos clínicos aleatorizados se contradicen en cuanto a la efectividad de la hidroxicloroquina; sin embargo, ambos comparten errores metodológicos y tamaños de muestra limitados; y un único ensayo no aleatorizado con los mismos errores demuestra efectividad de la hidroxicloroquina. En cuanto al perfil de seguridad se cuenta con información que evidencia una menor tasa de efectos adversos de la hidroxicloroquina frente a la cloroquina por lo que se preferiría su uso en caso de demostrar efectividad frente a COVID-19. Existen varios ensayos clínicos aleatorizados en curso que se espera esclarezcan las dudas que surgen al revisar la literatura.(Acta Med Colomb 2020; 45. DOI:https://doi.org/10.36104/amc.2020.1880).]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[treatment]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[coronavirus]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="es"><![CDATA[tratamiento]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[coronavirus]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
</kwd-group>
</article-meta>
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