<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-2448</journal-id>
<journal-title><![CDATA[Acta Medica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Med Colomb]]></abbrev-journal-title>
<issn>0120-2448</issn>
<publisher>
<publisher-name><![CDATA[Asociacion Colombiana de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-24482024000100002</article-id>
<article-id pub-id-type="doi">10.36104/amc.2024.3092</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Inborn errors of immunity. Childhood and adult diseases. A description of ambulatory clinical immunology patients over six years of tracking]]></article-title>
<article-title xml:lang="es"><![CDATA[Errores innatos de la inmunidad. Enfermedades de niños y adultos. Caracterización de pacientes de la consulta externa de inmunología clínica durante seis años de seguimiento]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandes-Pineda]]></surname>
<given-names><![CDATA[Mónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Matta-Cqrtés]]></surname>
<given-names><![CDATA[Lorena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zea-Vera]]></surname>
<given-names><![CDATA[Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Valle Departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario del Valle Departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle Departamento de Microbiología ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2024</year>
</pub-date>
<volume>49</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-24482024000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-24482024000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-24482024000100002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: inborn errors of immunity that present for the first time in adulthood are a recent topic of interest in internal medicine. First of all, this is a developing field within translational immunology, which internists should not overlook. Second, the number of adult patients with immunodeficiency symptoms seen by different medical services is increasing.  Design and method: in August 2015, a clinical immunology outpatient department was set up in the Hospital Universitario del Valle en Cali, Colombia. To describe the clinical experience with inborn errors of immunity in diagnosed adult patients, a cross-sectional study was conducted from 2015-2021.  Results: the ratio of males to females was 1.25:1, and all enrolled patients were over the age of 18. Antibody deficiency (40.7%) and common variable immunodeficiency were the most frequent categories and diagnoses, respectively. The patients' mean age at onset of symptoms was 24 years, with an average diagnostic delay of eight years.  Conclusion: understanding inborn errors of immunity (IEIs) is challenging and visionary for internists, entailing exploring new clinical areas and delving into clinical immunology. However, it is essential for achieving a more modern internal medicine. (Acta Med Colomb 2024; 49. DOI:https://doi.org/10.36104/amc.2024.3092).]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: los errores innatos de la inmunidad que se presentan por primera vez en la edad adulta, son un tema de reciente interés en la medicina interna. En primer término, se trata de un campo en desarrollo dentro de la inmunología traslacional, que no debe pasar desapercibido por los internistas. En segundo término, el número de pacientes adultos que acuden a diferentes servicios con síntomas de inmunodeficiencia está en aumento.  Diseño y metodología: en agosto de 2015, se estableció una consulta externa de inmunología clínica del Hospital Universitario del Valle en Cali, Colombia. Para caracterizar la experiencia clínica en errores innatos de la inmunidad en los pacientes adultos diagnosticados, se realizó un estudio de corte transversal en el periodo de 2015-2021.  Resultados: el radio de hombres a mujeres fue de 1.25:1, y el total de los pacientes incluidos eran mayores de 18 años. La deficiencia de anticuerpos (40.7%) y la inmunodeficiencia común variable fueron las categorías y diagnósticos más frecuentes, respectivamente. Los pacientes presentaron una edad media de inicio de síntomas a los 24 años y un retraso diagnóstico promedio de ocho años.  Conclusión: el conocimiento de los errores innatos de la inmunidad (EII) es desafiante y visionario para los internistas, implica adentrarse en nuevas áreas clínicas y profundizar en la inmunología clínica. Sin embargo, es esencial para alcanzar una medicina interna más moderna. (Acta Med Colomb 2024; 49. DOI: https://doi.org/10.36104/amc.2024.3092).]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[primary immunodeficiency]]></kwd>
<kwd lng="en"><![CDATA[translational immunology]]></kwd>
<kwd lng="en"><![CDATA[cross-sectional studies]]></kwd>
<kwd lng="en"><![CDATA[antibody deficiency]]></kwd>
<kwd lng="es"><![CDATA[inmunodeficiencia primaria]]></kwd>
<kwd lng="es"><![CDATA[inmunología traslacional]]></kwd>
<kwd lng="es"><![CDATA[estudios transversales]]></kwd>
<kwd lng="es"><![CDATA[deficiencia de anticuerpos]]></kwd>
</kwd-group>
</article-meta>
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