<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-2448</journal-id>
<journal-title><![CDATA[Acta Medica Colombiana]]></journal-title>
<abbrev-journal-title><![CDATA[Acta Med Colomb]]></abbrev-journal-title>
<issn>0120-2448</issn>
<publisher>
<publisher-name><![CDATA[Asociacion Colombiana de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-24482024000300003</article-id>
<article-id pub-id-type="doi">10.36104/amc.2024.3105</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[The prevalence of heterozygous familial hypercholesterolemia in northeastern Colombia in patients with established atherosclerosis]]></article-title>
<article-title xml:lang="es"><![CDATA[Prevalencia de hipercolesterolemia familiar heterocigota en el nororiente colombiano en pacientes con enfermedad aterosclerótica establecida]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[DELGADO-MUÑOZ]]></surname>
<given-names><![CDATA[ERIKA NOELIA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[PARRA-SERRANO]]></surname>
<given-names><![CDATA[GUSTAVO ADOLFO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[VESGA-ANGARITA]]></surname>
<given-names><![CDATA[BORIS EDUARDO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[LINDARTE-VARGAS]]></surname>
<given-names><![CDATA[HÉCTOR HENRY]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[SERRANO-GÓMEZ]]></surname>
<given-names><![CDATA[SERGIO EDUARDO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Especialista en Medicina Interna  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Especialista en Medicina Interna y Endocrinología  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Industrial de Santander  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Epidemiólogo  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad autónoma de Bucaramanga  ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<volume>49</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-24482024000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-24482024000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-24482024000300003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: Heterozygous familial hypercholesterolemia (HFH) is a genetic disorder characterized by elevated LDL-C, generally over 190 mg/dL, and a high risk of cardiovascular morbidity and mortality. Despite its high social and economic impact, it continues to be underdiagnosed and undertreated.  Objective: To determine the prevalence of HFH in patients with established atherosclerotic coronary and/or cerebrovascular disease, due to the lack of data in our population.  Methods: This was an observational analytical cross-sectional study of secondary anonymized data in two tertiary care cardiovascular and neurovascular institutions in northeastern Colombia. The inclusion criteria were: being 18 years old or older and having established atherosclerotic coronary and/or cerebrovascular disease. Patients for whom a lipid profile was not available were excluded. Prevalence was determined based on individuals classified as possible/probable cases; that is, those who had a score between 3 and 8, using the Dutch Lipid Clinic Network criteria. A database of 470 patients was reviewed.  Results: Altogether, 7.8% of the study population had possible/probable HFH. A statistically significant dependence was found between HFH and younger age at onset of cardiovascular events (55.83 years vs. 65.60 years), with 60% of the possible/probable cases being 40 years old or less. (Acta Med Colomb 2024; 49. DOI: https://doi.org/10.36104/amc.2024.3105).]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: La hipercolesterolemia familiar heterocigótica es un trastorno genético caracterizado por la elevación de c-LDL, generalmente por encima de 190 mg/dL y un alto riesgo de morbilidad y mortalidad cardiovascular. A pesar de su alto impacto social y económico, sigue siendo una patología subdiagnosticada y subtratada.  Objetivo: Establecer la prevalencia de hipercolesterolemia familiar heterocigótica (HFH) en pacientes con enfermedad coronaria y/o cerebrovascular aterosclerótica establecida debido a la falta de datos en nuestra población.  Métodos: Se desarrolló un estudio observacional, analítico y transversal de datos secundarios anonimizados en dos instituciones de alta complejidad en el área cardiovascular y neurovascular en el Nororiente Colombiano. Los criterios de inclusión fueron: edad de 18 años o más, pacientes con enfermedad coronaria y/o cerebrovascular aterosclerótica establecida; los pacientes sin un perfil lipídico evaluable fueron excluidos. La prevalencia se definió a partir de individuos clasificados como casos posibles/probables, es decir, aquellos que alcanzaron un puntaje entre 3 y 8 puntos de acuerdo con los criterios de la Red Holandesa de Clínicas de Lípidos. Se evaluó una base de datos de registro de 470 pacientes.  Resultados: El 7.8% de la población estudiada tiene hipercolesterolemia familiar heterocigótica posible/probable, se determinó una dependencia estadísticamente significativa entre la hipercolesterolemia familiar heterocigótica y la edad de presentación de eventos cardiovasculares más tempranos (55.83 años vs. 65.60 años), el 60% de los casos posibles / probables tenían 40 años o menos. (Acta Med Colomb 2024; 49. DOI: https://doi.org/10.36104/amc.2024.3105).]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[familial hypercholesterolemia]]></kwd>
<kwd lng="en"><![CDATA[coronary disease]]></kwd>
<kwd lng="en"><![CDATA[cerebrovascular disease]]></kwd>
<kwd lng="en"><![CDATA[atherosclerosis]]></kwd>
<kwd lng="en"><![CDATA[prevalence]]></kwd>
<kwd lng="es"><![CDATA[hipercolesterolemia familiar]]></kwd>
<kwd lng="es"><![CDATA[enfermedad coronaria]]></kwd>
<kwd lng="es"><![CDATA[enfermedad cerebrovascular]]></kwd>
<kwd lng="es"><![CDATA[enfermedad aterosclerótica]]></kwd>
<kwd lng="es"><![CDATA[prevalencia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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