<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0120-2804</journal-id>
<journal-title><![CDATA[Revista Colombiana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Colomb.Quim.]]></abbrev-journal-title>
<issn>0120-2804</issn>
<publisher>
<publisher-name><![CDATA[Departamento de Química,  Universidad Nacional de Colombia.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0120-28042017000300022</article-id>
<article-id pub-id-type="doi">10.15446/rev.colomb.quim.v46n3.62963</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Alcaloides aporfínicos con actividad antituberculosa aislados de Ocotea discolor Kunth (Lauraceae)]]></article-title>
<article-title xml:lang="en"><![CDATA[Aporphine alkaloids with antitubercular activity isolated from Ocotea discolor Kunth (Lauraceae)]]></article-title>
<article-title xml:lang="pt"><![CDATA[Alcalóides aporfirínicos com atividade antituberculosa isolados de Ocotea discolor Kunth (Lauraceae)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Albarracin]]></surname>
<given-names><![CDATA[Lady T.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Patino]]></surname>
<given-names><![CDATA[Oscar J.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzman]]></surname>
<given-names><![CDATA[Juan D.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Begum]]></surname>
<given-names><![CDATA[Neelu]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[McHugh]]></surname>
<given-names><![CDATA[Timothy D]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuca]]></surname>
<given-names><![CDATA[Luis E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ávila]]></surname>
<given-names><![CDATA[Mónica C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Colombia Facultad de Ciencias Departamento de Química]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad del Norte División de Ciencias Básicas Departamento de Química y Biología]]></institution>
<addr-line><![CDATA[Barranquilla ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,University College Department of Infection Center for Clinical Microbiology]]></institution>
<addr-line><![CDATA[London ]]></addr-line>
<country>UK</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2017</year>
</pub-date>
<volume>46</volume>
<numero>3</numero>
<fpage>22</fpage>
<lpage>27</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0120-28042017000300022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_abstract&amp;pid=S0120-28042017000300022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.co/scielo.php?script=sci_pdf&amp;pid=S0120-28042017000300022&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La tuberculosis causa miles de muertes a nivel mundial y, actualmente, los fármacos usados no son suficientes y en ocasiones son obsoletos para su tratamiento. Por tanto, se hace necesaria la búsqueda de nuevos compuestos que ayuden a combatirla. Se evaluó la actividad antituberculosis de los alcaloides ocoxilonina (1), ocoteina (2), dicentrina (3) y 1,2-metilendioxi-3, 10,11-trimetoxiaporfina (4), aislados de la madera de Ocotea discolor. Las estructuras fueron identificadas por medio del análisis de los datos espectroscópicos de resonancia magnética nuclear (NMR 1D - 1H, 13C, 2D -COSY, HSQC y HMBC), espectros de masas y comparación con datos de la literatura. Todos los compuestos aislados demostraron actividad antituberculosa, con un rango de variación en la concentración mínima inhibitoria entre 140 y 310 &#956;M, siendo la ocoteina (2) la más activa contra la cepa virulenta de Mycobacterium tuberculosis H37Rv.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Tuberculosis disease causes thousands of deaths worldwide and, currently, the used drugs are either not enough or obsolete for its treatment Therefore, new compounds that combat this disease are been seek Thus, the antituberculosis activity of the alkaloids ocoxilonine (1), ocoteine (2), dicentrine (3) and 1,2-methylenedioxy-3,10,11-trimethoxy aporphine (4), isolated from Ocotea discolor wood was evaluated Their structures were identified by analysis of nuclear magnetic resonance spectroscopic data (NMR 1D - 1H, 13C, 2D - COSY, HSQC and HMBC), mass spectra, and comparison with literature data All the isolated compounds showed antituberculosis activity, with a variation range in the minimum inhibitory concentration between 140 to 310 &#956;M, being ocoteine (2) the most active compound against the virulent strain Mycobacterium tuberculosis H37Rv.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo Devido a que a tuberculose provoca milhares de mortes em todo o mundo e a que, atualmente os medicamentos usados são inadequados e obsoletos para o tratamento desta doença, é preciso buscar novos compostos que ajudem a combatê-la. Assim, foi avaliada a atividade antituberculosis dos alcaloides ocoxilonina (1), ocoteina (2), dicentrina (3) y 1,2-metilendioxi-3,10,11-trimetoxiaporfina (4), isolados a partir da madeira de Ocotea discolor. Estas estruturas foram identificadas pela elucidação dos dados espectroscópicos (NMR 1D - 1H, 13C, 2D -COSY, HSQC e HMBC), espectros de massas e por comparação com os dados da literatura. Todos os compostos isolados demonstraram atividade antituberculosis, com um intervalo de variação na concentração inibitória mínima entre 140 e 310 &#956;M sendo a ocoteína (2) o composto mais ativo contra a variedade virulenta Mycobacterium tuberculosis H37Rv.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Mycobacterium tubercolosis]]></kwd>
<kwd lng="es"><![CDATA[datos espectroscópicos]]></kwd>
<kwd lng="es"><![CDATA[Ocoteina]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[spectroscopic data]]></kwd>
<kwd lng="en"><![CDATA[Ocotein]]></kwd>
<kwd lng="pt"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="pt"><![CDATA[dados espectroscópicas]]></kwd>
<kwd lng="pt"><![CDATA[Ocoteina]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="">
<collab>World Health Organization Genova (WHO)</collab>
<source><![CDATA[Global tuberculosis report]]></source>
<year>2016</year>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Approval of Novel TB Drug Celebrated--With Restraint]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cohen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Science]]></source>
<year>2013</year>
<volume>339</volume>
<page-range>130</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Casenghi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New approaches to filling the gap in tuberculosis drug discovery]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Cole S]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[GI Nathan]]></surname>
<given-names><![CDATA[C. F]]></given-names>
</name>
</person-group>
<source><![CDATA[PLoS Med]]></source>
<year>2007</year>
<volume>4</volume>
<page-range>e293</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Natural product growth inhibitors of Mycobacterium tuberculosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Copp]]></surname>
<given-names><![CDATA[B.R.]]></given-names>
</name>
<name>
<surname><![CDATA[Pearce]]></surname>
<given-names><![CDATA[A.N]]></given-names>
</name>
</person-group>
<source><![CDATA[Nat. Prod. Rep]]></source>
<year>2007</year>
<volume>24</volume>
<page-range>278-97</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antitubercular screening of natural products from Colombian plants: 3-methoxynordomesticine, an inhibitor of MurE ligase of Mycobacterium tuberculosis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guzman]]></surname>
<given-names><![CDATA[J. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Evangelopoulos]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Basavannacharya]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Pabón]]></surname>
<given-names><![CDATA[L. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Plazas]]></surname>
<given-names><![CDATA[E. A.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>2010</year>
<volume>65</volume>
<page-range>2101-7</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guzman]]></surname>
<given-names><![CDATA[J. D.]]></given-names>
</name>
<name>
<surname><![CDATA[Pesnot]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Barrera]]></surname>
<given-names><![CDATA[D. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Davies]]></surname>
<given-names><![CDATA[H. M.]]></given-names>
</name>
<name>
<surname><![CDATA[McMahon]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Evangelopoulos]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Antimicrob. Chemother]]></source>
<year>2015</year>
<volume>70</volume>
<page-range>1691-703</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chemical composition and biological activities of Ishpingo essential oil, a traditional Ecuadorian spice from Ocotea quixos (Lam.) Kosterm.(Lauraceae) flower calices]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bruni]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Medici]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Andreotti]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Fantin]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Muzzoli]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Dehesa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Food Chem]]></source>
<year>2004</year>
<volume>85</volume>
<page-range>415-21</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Composition and molluscicidal activity of the essential oil from the stem bark of Ocotea bracteosa (Meisn.) Mez]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coutinho]]></surname>
<given-names><![CDATA[D. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[C. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa-Filho]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Agra]]></surname>
<given-names><![CDATA[M. F.]]></given-names>
</name>
<name>
<surname><![CDATA[Martins]]></surname>
<given-names><![CDATA[R. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[T. M.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Essent. Oil Res]]></source>
<year>2007</year>
<volume>19</volume>
<page-range>482-4</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Leaf essential oil composition of 10 species of Ocotea (Lauraceae) from Monteverde, Costa Rica]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Takaku]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Haber]]></surname>
<given-names><![CDATA[W. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Setzer]]></surname>
<given-names><![CDATA[W. N]]></given-names>
</name>
</person-group>
<source><![CDATA[Biochem. Syst. Ecol]]></source>
<year>2007</year>
<volume>35</volume>
<page-range>525-32</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neolignans from bark and leaves of Ocotea porosa]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[David]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gottlieb]]></surname>
<given-names><![CDATA[O.R]]></given-names>
</name>
</person-group>
<source><![CDATA[Phytochemistry]]></source>
<year>1994</year>
<volume>36</volume>
<page-range>491-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neolignans from Ocotea catharinensis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ishige]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Motidome]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gottlieb]]></surname>
<given-names><![CDATA[O. R]]></given-names>
</name>
</person-group>
<source><![CDATA[Phytochemistry]]></source>
<year>1983</year>
<volume>22</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>4121-8</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Neolignans from leaves of Ocotea catharinensis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lordello]]></surname>
<given-names><![CDATA[A.L.L.]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Phytochemistry]]></source>
<year>1997</year>
<volume>46</volume>
<page-range>741-4</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Ocobullenone: a bicyclo [3.2. 1] octanoid neolignan from Ocotea bullata]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sehlapelo]]></surname>
<given-names><![CDATA[B. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Drewes]]></surname>
<given-names><![CDATA[S. E.]]></given-names>
</name>
<name>
<surname><![CDATA[Sandor]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Phytochemistry]]></source>
<year>1993</year>
<volume>32</volume>
<page-range>1352-3</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[New lignan from Ocotea duckei]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morais]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Pachú]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa-Filho]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<source><![CDATA[Fitoterapia]]></source>
<year>1996</year>
<volume>67</volume>
<page-range>557</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The aporphine and isoquinolinedienone alkaloids of Ocotea glaziovii]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gilbert]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Gilbert]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[De Oliveira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ribeiro]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Wenkert]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Wickberg]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Am. Chem. Soc]]></source>
<year>1964</year>
<volume>86</volume>
<page-range>694-6</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Aporphine alkaloids of Ocotea brenesii]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[J. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Barillas]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Gomez-Laurito]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[F.-T.]]></given-names>
</name>
<name>
<surname><![CDATA[Al-Rehaily]]></surname>
<given-names><![CDATA[A.J.]]></given-names>
</name>
<name>
<surname><![CDATA[Sharaf]]></surname>
<given-names><![CDATA[M.H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Int. J. Pharmacogn]]></source>
<year>1996</year>
<volume>34</volume>
<page-range>145-7</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Aporphine alkaloids from Ocotea macrophylla (Lauraceae]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pabon]]></surname>
<given-names><![CDATA[L C]]></given-names>
</name>
<name>
<surname><![CDATA[Cuca]]></surname>
<given-names><![CDATA[L E]]></given-names>
</name>
</person-group>
<source><![CDATA[Quím. Nova]]></source>
<year>2010</year>
<volume>33</volume>
<page-range>875-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Lauraceae alkaloids]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Custodio]]></surname>
<given-names><![CDATA[D L]]></given-names>
</name>
<name>
<surname><![CDATA[da Veiga Junior]]></surname>
<given-names><![CDATA[V F]]></given-names>
</name>
</person-group>
<source><![CDATA[RSC Adv]]></source>
<year>2014</year>
<volume>4</volume>
<page-range>21864-90</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cytotoxic aporphine alkaloids from Ocotea acutifolia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garcez]]></surname>
<given-names><![CDATA[F R]]></given-names>
</name>
<name>
<surname><![CDATA[Francisca]]></surname>
<given-names><![CDATA[d S A]]></given-names>
</name>
<name>
<surname><![CDATA[Garcez]]></surname>
<given-names><![CDATA[W S]]></given-names>
</name>
<name>
<surname><![CDATA[Linck]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[de Fatima]]></surname>
<given-names><![CDATA[M. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
<name>
<surname><![CDATA[Queiroz]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<source><![CDATA[Planta Med]]></source>
<year>2011</year>
<volume>77</volume>
<page-range>383-7</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Andrei]]></surname>
<given-names><![CDATA[C C]]></given-names>
</name>
<name>
<surname><![CDATA[Braz-filho]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gottlieb]]></surname>
<given-names><![CDATA[O R]]></given-names>
</name>
</person-group>
<source><![CDATA[Allylphenols from Ocotea cymbarum Phytochemistry]]></source>
<year>1988</year>
<volume>27</volume>
<page-range>3992-3</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[David]]></surname>
<given-names><![CDATA[J M]]></given-names>
</name>
<name>
<surname><![CDATA[Yoshida]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gottlieb]]></surname>
<given-names><![CDATA[O R]]></given-names>
</name>
</person-group>
<source><![CDATA[henylpropanoid-catechins from bark of Ocotea porosa Phytochemistry]]></source>
<year>1994</year>
<volume>35</volume>
<page-range>545-6</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[de Diaz]]></surname>
<given-names><![CDATA[A M]]></given-names>
</name>
<name>
<surname><![CDATA[Gottlieb]]></surname>
<given-names><![CDATA[H E]]></given-names>
</name>
<name>
<surname><![CDATA[Gottlieb]]></surname>
<given-names><![CDATA[O R]]></given-names>
</name>
</person-group>
<source><![CDATA[Dehydrodieugenols from Ocotea cymbarum Phytochemistry]]></source>
<year>1980</year>
<volume>19</volume>
<page-range>681-2</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chemical composition and antibacterial activity of the essential oil from bark of Ocotea puberula (Rich ) Ness]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Farago]]></surname>
<given-names><![CDATA[P. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Nakashima]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Doll]]></surname>
<given-names><![CDATA[P. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Jane]]></surname>
<given-names><![CDATA[M. B.]]></given-names>
</name>
<name>
<surname><![CDATA[Maia]]></surname>
<given-names><![CDATA[B. H]]></given-names>
</name>
</person-group>
<source><![CDATA[Lat Am J Pharm]]></source>
<year>2010</year>
<volume>29</volume>
<page-range>1242-5</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Analysis of the fungicidal constituents from the bark of Ocotea usambarensis Engl (Lauraceae)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Terreaux]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Maillard]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hostettmann]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Lodi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hakizamungu]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<source><![CDATA[Phytochem Anal]]></source>
<year>1994</year>
<volume>5</volume>
<page-range>233-8</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antifungal effects of ellagitannin isolated from leaves of Ocotea odorifera (Lauraceae)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yamaguchi]]></surname>
<given-names><![CDATA[M U]]></given-names>
</name>
<name>
<surname><![CDATA[Garcia]]></surname>
<given-names><![CDATA[F P]]></given-names>
</name>
<name>
<surname><![CDATA[Cortez]]></surname>
<given-names><![CDATA[D A G]]></given-names>
</name>
<name>
<surname><![CDATA[Ueda-Nakamura]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Dias Filho]]></surname>
<given-names><![CDATA[B P]]></given-names>
</name>
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[C V]]></given-names>
</name>
</person-group>
<source><![CDATA[Antonie Van Leeuwenhoek]]></source>
<year>2011</year>
<volume>99</volume>
<page-range>507-14</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fournet]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[M E]]></given-names>
</name>
<name>
<surname><![CDATA[de Arias]]></surname>
<given-names><![CDATA[A R]]></given-names>
</name>
<name>
<surname><![CDATA[Guy]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Guinaudeau]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Heinzen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<source><![CDATA[Phytochemical and antiprotozoal activity of Ocotea lancifolia Fitoterapia]]></source>
<year>2007</year>
<volume>78</volume>
<page-range>382-4</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Evaluation of the mutagenic potential of yangambin and of the hydroalcoholic extract of Ocotea duckei by the Ames test]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Marques]]></surname>
<given-names><![CDATA[R C P]]></given-names>
</name>
<name>
<surname><![CDATA[da Silva Dias]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa-Filho]]></surname>
<given-names><![CDATA[J M]]></given-names>
</name>
<name>
<surname><![CDATA[Agnez-Lima]]></surname>
<given-names><![CDATA[L F]]></given-names>
</name>
</person-group>
<source><![CDATA[Mutat. Res., Genet. Toxicol. Environ. Mutagen]]></source>
<year>2003</year>
<volume>536</volume>
<page-range>117-20</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Yangambin cytotoxicity: a pharmacologically active lignan obtained from Ocotea duckei vattimo (Lauraceae)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Monte Neto]]></surname>
<given-names><![CDATA[R. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Sousa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Dias]]></surname>
<given-names><![CDATA[C. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa Filho]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[M. R]]></given-names>
</name>
</person-group>
<source><![CDATA[Z. Naturforschung C]]></source>
<year>2008</year>
<volume>63</volume>
<page-range>681-6</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Isolation and Biochemical Characterization of a New Topoisomerase I Inhibitor from Ocotea leucoxylon]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[B. N.]]></given-names>
</name>
<name>
<surname><![CDATA[Johnson]]></surname>
<given-names><![CDATA[R. K.]]></given-names>
</name>
<name>
<surname><![CDATA[Mattern]]></surname>
<given-names><![CDATA[M. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Hecht]]></surname>
<given-names><![CDATA[S. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Beck]]></surname>
<given-names><![CDATA[H. T.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Nat. Prod]]></source>
<year>2000</year>
<volume>63</volume>
<page-range>217-21</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Recent advances in antitubercular natural products]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bocanegra-García]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Palma-Nicolás]]></surname>
<given-names><![CDATA[J. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Rivera]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Eur. J. Med. Chem]]></source>
<year>2012</year>
<volume>49</volume>
<page-range>1-23</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="">
<source><![CDATA[Tropicos]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="book">
<collab>Merck</collab>
<source><![CDATA[Reactivos de coloración para cromatografía en capa fina y en papel]]></source>
<year>1972</year>
<page-range>154</page-range><publisher-name><![CDATA[E. Merk]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zanin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Alcalóides aporfinóides em mudas de Ocotea puberula (Reich.) Nees (LAURACEAE)]]></source>
<year>2006</year>
<publisher-loc><![CDATA[Doutor em Química, Setor de Ciências Exatas, Universidade Federal do Paraná ]]></publisher-loc>
</nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balci]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Basic 1H-13C- NMR Spectroscopy: 1]]></source>
<year>2005</year>
<page-range>117</page-range><publisher-loc><![CDATA[Ankara ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Isoquinoline alkaloid N-oxides from Thalictrum simplex]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Velcheva]]></surname>
<given-names><![CDATA[M. P.]]></given-names>
</name>
<name>
<surname><![CDATA[Petrova]]></surname>
<given-names><![CDATA[R. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Samdanghiin]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Danghaaghiin]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Yansanghiin]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Budzikiewicz]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Phytochemistry]]></source>
<year>1996</year>
<volume>42</volume>
<page-range>535-7</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Cytotoxic aporphine alkaloids from Ocotea acutifolia]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Garcez]]></surname>
<given-names><![CDATA[F. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Francisca]]></surname>
<given-names><![CDATA[d. S. A.]]></given-names>
</name>
<name>
<surname><![CDATA[Garcez]]></surname>
<given-names><![CDATA[W. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Linck]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[de Fatima]]></surname>
<given-names><![CDATA[M. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Santos]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Planta Med]]></source>
<year>2011</year>
<volume>77</volume>
<page-range>383-7</page-range></nlm-citation>
</ref>
<ref id="B37">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Alkaloidal variation in Cissampelos capensis (Menispermaceae)]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[De Wet]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Van Heerden]]></surname>
<given-names><![CDATA[F. R.]]></given-names>
</name>
<name>
<surname><![CDATA[Van Wyk]]></surname>
<given-names><![CDATA[B. E]]></given-names>
</name>
</person-group>
<source><![CDATA[Molecules]]></source>
<year>2011</year>
<volume>16</volume>
<page-range>3001-9</page-range></nlm-citation>
</ref>
<ref id="B38">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Vasorelaxing alkaloids and flavonoids from Cassytha filiformis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tsai]]></surname>
<given-names><![CDATA[T. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[G. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[L. C]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Nat. Prod]]></source>
<year>2008</year>
<volume>71</volume>
<page-range>289-91</page-range></nlm-citation>
</ref>
<ref id="B39">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Antimycobacterial Compounds from Piper santum]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mata]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Morales]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Perez]]></surname>
<given-names><![CDATA[O.]]></given-names>
</name>
<name>
<surname><![CDATA[Rivero-Cruz]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Acevedo]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Enriquez-Mendoza]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Nat. Prod]]></source>
<year>2004</year>
<volume>67</volume>
<page-range>1961-8</page-range></nlm-citation>
</ref>
<ref id="B40">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Bioactive Styryllactones and alkaloid from flowers of Goniothalamus laoticus]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lekphrom]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kanokmedhakul]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kanokmedhakul]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<source><![CDATA[J. Ethnopharmacol]]></source>
<year>2009</year>
<volume>125</volume>
<page-range>47-50</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
